Wissenschaftliche Artikel

Rahm, M., Keppel, P., Šlachtová, V., Dzijak, R., Dračínský, M., Bellová, S., Reyes-Gutiérrez, P. E., Štěpánová, S., Raffler, J., Tloušťová, E., Mertlíková-Kaiserová, H., Mikula, H., & Vrabel, M. (2024). Sulfonated Hydroxyaryl-Tetrazines with Increased pKa for Accelerated Bioorthogonal Click-to-Release Reactions in Cells. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Article e202411713. https://doi.org/10.1002/anie.202411713 ( reposiTUm)
Wilkovitsch, M., Kuba, W., Keppel, P., Sohr, B., Löffler, A., Kronister, S., Del Castillo, A. F., Goldeck, M., Dzijak, R., Rahm, M., Vrabel, M., Svatunek, D., Carlson, J. C. T., & Mikula, H. (2024). Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Article e202411707. https://doi.org/10.1002/anie.202411707 ( reposiTUm)
Wilkovitsch, M., Svatunek, D., Mikula, H., & Denk, C. (2023). Post-radiolabeling thioether oxidation to enhance the bioorthogonal reactivity of 18F-tetrazines. MONATSHEFTE FUR CHEMIE, 154(12), 1441–1457. https://doi.org/10.1007/s00706-023-03140-w ( reposiTUm)
Mikula, H. (2023). Special issue in memoriam Fritz Sauter. MONATSHEFTE FUR CHEMIE, 154, 1315–1316. https://doi.org/10.1007/s00706-023-03141-9 ( reposiTUm)
Houszka, N., Mikula, H., & Svatunek, D. (2023). Substituent Effects in Bioorthogonal Diels-Alder Reactions of 1,2,4,5-Tetrazines. CHEMISTRY-A EUROPEAN JOURNAL, 29(29), Article e202300345. https://doi.org/10.1002/chem.202300345 ( reposiTUm)
Shalgunov, V., Lopes van den Broek, S., Vang Andersen, I., Garcia Vazquez, R., Raval, N., Palner, M., Mori, Y., Schäfer, G., Herrmann, B., Mikula, H., Beschorner, N., Nedergaard, M., Syvänen, S., Barz, M., Moos Knudsen, G., Battisti, U. M., & Herth, M. M. (2023). Pretargeted imaging beyond the blood-brain barrier. RSC Medicinal Chemistry, 14(3), 444–453. https://doi.org/10.1039/d2md00360k ( reposiTUm)
Pavicich, M. A., De Boevre, M., Vidal, A., Mikula, H., Warth, B., Marko, D., De Saeger, S., & Patriarca, A. (2023). Natural Occurrence, Exposure Assessment & Risk Characterization of Alternaria Mycotoxins in Apple By-Products in Argentina. Exposure and Health. https://doi.org/10.1007/s12403-023-00544-1 ( reposiTUm)
Kuba, W., Sohr, B., Keppel, P., Svatunek, D., Humhal, V., Stöger, B., Goldeck, M., Carlson, J. C. T., & Mikula, H. (2023). Oxidative Desymmetrization Enables the Concise Synthesis of a trans-Cyclooctene Linker for Bioorthogonal Bond Cleavage. Chemistry - A European Journal, 29(3), Article e202203069. https://doi.org/10.1002/chem.202203069 ( reposiTUm)
Svatunek, D., Wilkovitsch, M., Hartmann, L., Houk, K. N., & Mikula, H. (2022). Uncovering the Key Role of Distortion in Bioorthogonal Tetrazine Tools That Defy the Reactivity/Stability Trade-Off. Journal of the American Chemical Society, 144(18), 8171–8177. https://doi.org/10.1021/jacs.2c01056 ( reposiTUm)
Svatunek, D., Houszka, N., Hamlin, T. A., Bickelhaupt, F. M., & Mikula, H. (2022). Corrigendum: Chemoselectivity of Tertiary Azides in Strain-Promoted Alkyne-Azide Cycloadditions. Chemistry - A European Journal, 28(19), Article e202200414. https://doi.org/10.1002/chem.202200414 ( reposiTUm)
Battisti, U. M., García-Vázquez, R., Svatunek, D., Herrmann, B., Löffler, A., Mikula, H., & Herth, M. M. (2022). Synergistic Experimental and Computational Investigation of the Bioorthogonal Reactivity of Substituted Aryltetrazines. Bioconjugate Chemistry, 33(4), 608–624. https://doi.org/10.1021/acs.bioconjchem.2c00042 ( reposiTUm)
Ng, T. S. C., Hu, H., Kronister, S., Lee, C., Li, R., Gerosa, L., Stopka, S. A., Burgenske, D. M., Khurana, I., Regan, M. S., Vallabhaneni, S., Putta, N., Scott, E., Matvey, D., Giobbie-Hurder, A., Kohler, R. H., Sarkaria, J. N., Parangi, S., Sorger, P. K., … Miller, M. A. (2022). Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy. Science Advances, 8(17), Article eabl6339. https://doi.org/10.1126/sciadv.abl6339 ( reposiTUm)
Ko, J., Wilkovitsch, M., Oh, J., Kohler, R. H., BOLLI, E., Pittet, M. J., Vinegoni, C., Sykes, D. B., Mikula, H., Weissleder, R., & Carlson, J. C. T. (2022). Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes. Nature Biotechnology, 40, 1654–1662. https://doi.org/10.1038/s41587-022-01339-6 ( reposiTUm)
Keppel, P., Sohr, B., Kuba, W., Goldeck, M., Skrinjar, P., Carlson, J. C. T., & Mikula, H. (2022). Tetrazine-Triggered Bioorthogonal Cleavage of trans-Cyclooctene-Caged Phenols Using a Minimal Self-Immolative Linker Strategy. ChemBioChem, 23(20), Article e202200363. https://doi.org/10.1002/cbic.202200363 ( reposiTUm)
Steen, E. J. L., Jørgensen, J. T., Denk, C., Battisti, U. M., Nørregaard, K., Edem, P. E., Bratteby, K., Shalgunov, V., Wilkovitsch, M., Svatunek, D., Poulie, C., Hvass, L., Simón, M., Wanek, T., Rossin, R., Robillard, M., Kristensen, J., Mikula, H., Kjaer, A., & Herth, M. (2021). Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry. ACS Pharmacology & Translational Science, 4(2), 824–833. https://doi.org/10.1021/acsptsci.1c00007 ( reposiTUm)
Li, R., Ng, T. S. C., Wang, S. J., Prytyskach, M., Rodell, C. B., Mikula, H., Kohler, R. H., Garlin, M. A., Lauffenburger, D. A., Parangi, S., Dinulescu, D. M., Bardeesy, N., Weissleder, R., & Miller, M. A. (2021). Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Nature Nanotechnology, 16(7), 830–839. https://doi.org/10.1038/s41565-021-00897-1 ( reposiTUm)
García-Vázquez, R., Battisti, U. M., Jørgensen, J. T., Shalgunov, V., Hvass, L., Stares, D. L., Petersen, I. N., Crestey, F., Löffler, A., Svatunek, D., Kristensen, J. L., Mikula, H., Kjaer, A., & Herth, M. M. (2021). Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging. Chemical Science, 12(35), 11668–11675. https://doi.org/10.1039/d1sc02789a ( reposiTUm)
Battisti, U. M., Bratteby, K., Jørgensen, J. T., Hvass, L., Shalgunov, V., Mikula, H., Kjær, A., & Herth, M. M. (2021). Development of the First Aliphatic 18F-Labeled Tetrazine Suitable for Pretargeted PET Imaging-Expanding the Bioorthogonal Tool Box. Journal of Medicinal Chemistry, 64(20), 15297–15312. https://doi.org/10.1021/acs.jmedchem.1c01326 ( reposiTUm)
Colon-Berrios, A. R., McGinn, C. K., Cavallari, M. R., Bahamonde, J. A., Yelavik, N., Mikula, H., Bintinger, J., & Kymissis, I. (2020). Improved Cyclohexanone Vapor Detection via Gravimetric Sensing. Journal of Microelectromechanical Systems, 29(5), 1253–1263. https://doi.org/10.1109/jmems.2020.3010463 ( reposiTUm)
Svatunek, D., Eilenberger, G., Denk, C., Lumpi, D., Hametner, C., Allmaier, G., & Mikula, H. (2020). Live Monitoring of Strain‐Promoted Azide Alkyne Cycloadditions in Complex Reaction Environments by Inline ATR‐IR Spectroscopy. Chemistry - A European Journal, 26(44), 9851–9854. https://doi.org/10.1002/chem.201905478 ( reposiTUm)
Schwarz, M., Skrinjar, P., Fink, M. J., Kronister, S., Mechtler, T., Koukos, P. I., Bonvin, A. M. J. J., Kasper, D. C., & Mikula, H. (2020). A click-flipped enzyme substrate boosts the performance of the diagnostic screening for Hunter syndrome. Chemical Science, 11(47), 12671–12676. https://doi.org/10.1039/d0sc04696e ( reposiTUm)
Johann, K., Svatunek, D., Seidl, C., Rizzelli, S., Bauer, T. A., Braun, L., Koynov, K., Mikula, H., & Barz, M. (2020). Tetrazine- and trans-cyclooctene-functionalised polypept(o)ides for fast bioorthogonal tetrazine ligation. Polymer Chemistry, 11(27), 4396–4407. https://doi.org/10.1039/d0py00375a ( reposiTUm)
Pavicich, M. A., De Boevre, M., Vidal, A., Iturmendi, F., Mikula, H., Warth, B., Marko, D., De Saeger, S., & Patriarca, A. (2020). Fate of free and modified Alternaria mycotoxins during the production of apple concentrates. Food Control, 118(107388), 107388. https://doi.org/10.1016/j.foodcont.2020.107388 ( reposiTUm)
Garcia Vazquez, R., Battisti, U. M., Lloyd Stares, D., Nymann Petersen, I., Crestey, F., Svatunek, D., Mikula, H., Kristensen, J., Kjaer, A., & Herth, M. (2020). Direct Aromatic 18F-labeling of Tetrazines: A Rapid and Convenient Entry to Tetrazines for Pretargeted PET Imaging. Journal of Nuclear Medicine, 61(Supplement 1), 134. http://hdl.handle.net/20.500.12708/141726 ( reposiTUm)
Wilkovitsch, M., Haider, M., Sohr, B., Herrmann, B., Klubnick, J., Weissleder, R., Carlson, J. C. T., & Mikula, H. (2020). A Cleavable C₂-Symmetric trans-Cyclooctene Enables Fast and Complete Bioorthogonal Disassembly of Molecular Probes. Journal of the American Chemical Society, 142(45), 19132–19141. https://doi.org/10.1021/jacs.0c07922 ( reposiTUm)
Steen, E. J. L., Jørgensen, J. T., Johann, K., Nørregaard, K., Sohr, B., Svatunek, D., Birke, A., Shalgunov, V., Edem, P. E., Rossin, R., Seidl, C., Schmid, F., Robillard, M. S., Kristensen, J. L., Mikula, H., Barz, M., Kjær, A., & Herth, M. M. (2019). Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging. ACS Nano, 14(1), 568–584. https://doi.org/10.1021/acsnano.9b06905 ( reposiTUm)
Svatunek, D., Houszka, N., Hamlin, T. A., Bickelhaupt, F. M., & Mikula, H. (2019). Chemoselectivity of Tertiary Azides in Strain‐Promoted Alkyne‐Azide Cycloadditions. Chemistry - A European Journal, 25(3), 754–758. https://doi.org/10.1002/chem.201805215 ( reposiTUm)
Steen, E. J., Shalgunov, V., Denk, C., Mikula, H., Kjaer, A., Kristensen, J., & Herth, M. (2019). Convenient Entry to 18F-labeled Amines Through the Staudinger Reduction. European Journal of Organic Chemistry, 2019(8), 1722–1725. http://hdl.handle.net/20.500.12708/142445 ( reposiTUm)
Rosecker, V., Denk, C., Maurer, M., Wilkovitsch, M., Mairinger, S., Wanek, T., & Mikula, H. (2019). Cross‐Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications. ChemBioChem, 20(12), 1530–1535. https://doi.org/10.1002/cbic.201900042 ( reposiTUm)
Weber, J., Svatunek, D., Krauter, S., Tegl, G., Hametner, C., Kosma, P., & Mikula, H. (2019). 2-O-Benzyloxycarbonyl protected glycosyl donors: a revival of carbonate-mediated anchimeric assistance for diastereoselective glycosylation. Chemical Communications, 55(83), 12543–12546. https://doi.org/10.1039/c9cc07194f ( reposiTUm)
Kramer, S., Svatunek, D., Alberg, I., Gräfen, B., Schmitt, S., Braun, L., van Onzen, A. H. A. M., Rossin, R., Koynov, K., Mikula, H., & Zentel, R. (2019). HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation. Biomacromolecules, 20(10), 3786–3797. https://doi.org/10.1021/acs.biomac.9b00868 ( reposiTUm)
Denk, C., Wilkovitsch, M., Aneheim, E., Herth, M. M., Jensen, H., Lindegren, S., & Mikula, H. (2019). Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking. ChemPlusChem, 84(7), 774–774. https://doi.org/10.1002/cplu.201900250 ( reposiTUm)
Levandowski, B. J., Svatunek, D., Sohr, B., Mikula, H., & Houk, K. N. (2019). Secondary Orbital Interactions Enhance the Reactivity of Alkynes in Diels-Alder Cycloadditions. Journal of the American Chemical Society, 141(6), 2224–2227. https://doi.org/10.34726/2101 ( reposiTUm)
Svatunek, D., Denk, C., & Mikula, H. (2018). A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines. Monatshefte Für Chemie - Chemical Monthly. https://doi.org/10.1007/s00706-017-2110-x ( reposiTUm)
Carlson, J. C. T., Mikula, H., & Weissleder, R. (2018). Unraveling tetrazine-triggered bioorthogonal elimination enables chemical tools for ultrafast release and universal cleavage. Journal of the American Chemical Society, 140(10), 3603–3612. https://doi.org/10.1021/jacs.7b11217 ( reposiTUm)
Weber, J., Vaclavikova, M., Wiesenberger, G., Haider, M., Hametner, C., Fröhlich, J., Berthiller, F., Adam, G., Mikula, H., & Fruhmann, P. (2018). Chemical synthesis of culmorin metabolites and their biologic role in culmorin and acetyl-culmorin treated wheat cells. Organic and Biomolecular Chemistry, 16(12), 2043–2048. https://doi.org/10.1039/c7ob02460f ( reposiTUm)
Miller, M. A., Mikula, H., Luthria, G., Li, R., Kronister, S., Prytyskach, M., Kohler, R. H., Mitchison, T., & Weissleder, R. (2018). Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano, 12(12), 12814–12826. https://doi.org/10.1021/acsnano.8b07954 ( reposiTUm)
Skrinjar, P., Schwarz, M., Lexmüller, S., Mechtler, T. P., Zeyda, M., Greber-Platzer, S., Trometer, J., Kasper, D. C., & Mikula, H. (2018). Rapid and Modular Assembly of Click Substrates To Assay Enzyme Activity in the Newborn Screening of Lysosomal Storage Disorders. ACS Central Science, 4(12), 1688–1696. https://doi.org/10.1021/acscentsci.8b00668 ( reposiTUm)
Weber, J., Krauter, S., Schwarz, T., Hametner, C., & Mikula, H. (2018). (2-Benzyloxyphenyl)acetyl (BnPAc): A Participating Relay Protecting Group for Diastereoselective Glycosylation and the Synthesis of 1,2-trans Glycosyl Esters. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 29(17), 2265–2268. https://doi.org/10.1055/s-0037-1610255 ( reposiTUm)
Kronister, S., Svatunek, D., Denk, C., & Mikula, H. (2018). Acylation-Mediated “Kinetic Turn-On” of 3-Amino-1,2,4,5-tetrazines. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 29(10), 1297–1302. https://doi.org/10.1055/s-0036-1591764 ( reposiTUm)
Puntscher, H., Kütt, M.-L., Skrinjar, P., Mikula, H., Podlech, J., Fröhlich, J., Marko, D., & Warth, B. (2018). Tracking emerging mycotoxins in food: development of an LC-MS/MS method for free and modified Alternaria toxins. Analytical and Bioanalytical Chemistry, 410(18), 4481–4494. https://doi.org/10.1007/s00216-018-1105-8 ( reposiTUm)
Dellafiora, L., Warth, B., Schmidt, V., Del Favero, G., Mikula, H., Fröhlich, J., & Marko, D. (2018). An integrated in silico/in vitro approach to assess the xenoestrogenic potential of Alternaria mycotoxins and metabolites. Food Chemistry, 248, 253–261. https://doi.org/10.1016/j.foodchem.2017.12.013 ( reposiTUm)
Weber, J., Schwarz, M., Schiefer, A., Hametner, C., Häubl, G., Fröhlich, J., & Mikula, H. (2018). Chemical Glucosylation of Labile Natural Products using a (2‐Nitrophenyl)acetyl‐Protected Glucosyl Acetimidate Donor. European Journal of Organic Chemistry, 2018(20–21), 2701–2706. https://doi.org/10.1002/ejoc.201800260 ( reposiTUm)
Pineda, J. J., Miller, M. A., Song, Y., Kuhn, H., Mikula, H., Tallapragada, N., Weissleder, R., & Mitchison, T. J. (2018). Site occupancy calibration of taxane pharmacology in live cells and tissues. Proceedings of the National Academy of Sciences, 115(48), E11414. https://doi.org/10.1073/pnas.1800047115 ( reposiTUm)
Bintinger, J., Yang, S., Fruhmann, P., Holzer, B., Stöger, B., Svirkova, A., Marchetti-Deschmann, M., Horkel, E., Hametner, C., Fröhlich, J., Kymissis, I., & Mikula, H. (2017). Synthesis, characterization and printing application of alkylated indolo[3,2-b]carbazoles. Synthetic Metals, 228, 9–17. https://doi.org/10.1016/j.synthmet.2017.04.003 ( reposiTUm)
Denk, C., Wilkovitsch, M., Skrinjar, P., Svatunek, D., Mairinger, S., Kuntner, C., Filip, T., Fröhlich, J., Wanek, T., & Mikula, H. (2017). [18F]Fluoroalkyl azides for rapid radiolabeling and (Re)investigation of their potential towards in vivo click chemistry. Organic and Biomolecular Chemistry, 15(28), 5976–5982. https://doi.org/10.1039/c7ob00880e ( reposiTUm)
Miller, M. A., Askevold, B., Mikula, H., Kohler, R. H., Pirovich, D., & Weissleder, R. (2017). Nano-palladium is a cellular catalyst for in vivo chemistry. Nature Communications, 8(15906). https://doi.org/10.1038/ncomms15906 ( reposiTUm)
Mikula, H., Stapleton, S., Kohler, R. H., Vinegoni, C., & Weissleder, R. (2017). Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging. Theranostics, 7(5), 1257–1265. https://doi.org/10.7150/thno.18238 ( reposiTUm)
Tiessen, C., Ellmer, D., Mikula, H., Pahlke, G., Warth, B., Gehrke, H., Zimmermann, K., Heiss, E., Fröhlich, J., & Marko, D. (2017). Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells. Archives of Toxicology, 91(3), 1213–1226. https://doi.org/10.1007/s00204-016-1801-0 ( reposiTUm)
Weber, J., Fruhmann, P., Hametner, C., Schiessl, A., Häubl, G., Fröhlich, J., & Mikula, H. (2017). Synthesis of Isotope-Labeled Deoxynivalenol-15-O-Glycosides. European Journal of Organic Chemistry, 2017(47), 7012–7018. http://hdl.handle.net/20.500.12708/147079 ( reposiTUm)
Svatunek, D., Denk, C., Rosecker, V., Sohr, B., Hametner, C., Allmaier, G., Fröhlich, J., & Mikula, H. (2016). Efficient low-cost preparation of trans-cyclooctenes using a simplified flow setup for photoisomerization. Monatshefte Für Chemie - Chemical Monthly. https://doi.org/10.1007/s00706-016-1668-z ( reposiTUm)
Denk, C., Svatunek, D., Mairinger, S., Stanek, J., Filip, T., Matscheko, D., Kuntner, C., Wanek, T., & Mikula, H. (2016). Design, Synthesis, and Evaluation of a Low-Molecular-Weight 11C-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry. Bioconjugate Chemistry, 27(7), 1707–1712. https://doi.org/10.1021/acs.bioconjchem.6b00234 ( reposiTUm)
Walravens, J., Mikula, H., Rychlik, M., Asam, S., Devos, T., Njumbe Ediage, E., Diana Di Mavungu, J., Jacxsens, L., Van Landschoot, A., Vanhaecke, L., & De Saeger, S. (2016). Validated UPLC-MS/MS Methods To Quantitate Free and Conjugated Alternaria Toxins in Commercially Available Tomato Products and Fruit and Vegetable Juices in Belgium. Journal of Agricultural and Food Chemistry, 64(24), 5101–5109. https://doi.org/10.1021/acs.jafc.6b01029 ( reposiTUm)
Meimetis, L. G., Giedt, R. J., Mikula, H., Carlson, J. C., Kohler, R. H., Pirovich, D. B., & Weissleder, R. (2016). Fluorescent vinblastine probes for live cell imaging. Chemical Communications, 52(64), 9953–9956. https://doi.org/10.1039/c6cc04129a ( reposiTUm)
Denk, C., Svatunek, D., Wanek, T., Mairinger, S., Stanek, J., Filip, T., Fröhlich, J., Mikula, H., & Kuntner, C. (2016). Bioorthogonal Tools for PET Imaging: Development of Radiolabeled 1,2,4,5-Tetrazines. EJNMMI Research, 6(Suppl 1), 8–9. http://hdl.handle.net/20.500.12708/49563 ( reposiTUm)
Denk, C., Svatunek, D., Sohr, B., Mikula, H., Fröhlich, J., Wanek, T., Kuntner, C., & Filip, T. (2016). Investigation of Small [18F]-Fluoroalkylazides for Rapid Radiolabeling and In Vivo Click Chemistry. EJNMMI Research, 6(Suppl 1), 9–9. http://hdl.handle.net/20.500.12708/49564 ( reposiTUm)
Svatunek, D., Denk, C., Wilkovitsch, M., Fröhlich, J., Wanek, T., Filip, T., Kuntner, C., & Mikula, H. (2016). 18F labeled azidoglucose derivatives as “click” agents for pretargeted PET imaging. EJNMMI Research, 6(Suppl 1), 8–8. http://hdl.handle.net/20.500.12708/49707 ( reposiTUm)
Kim, E., Yang, K. S., Kohler, R. H., Dubach, J. M., Mikula, H., & Weissleder, R. (2015). Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression. Bioconjugate Chemistry, 26(8), 1513–1518. https://doi.org/10.1021/acs.bioconjchem.5b00152 ( reposiTUm)
Fruhmann, P., Hametner, C., Mikula, H., Adam, G., Krska, R., & Fröhlich, J. (2014). Stereoselective Luche Reduction of Deoxynivalenol and Three of Its Acetylated Derivatives at C8. Toxins, 6(1), 325–336. https://doi.org/10.3390/toxins6010325 ( reposiTUm)
Mikula, H., Weber, J., Svatunek, D., Skrinjar, P., Adam, G., Krska, R., Hametner, C., & Fröhlich, J. (2014). Synthesis of Zearalenone-16-β,D-Glucoside and Zearalenone-16-Sulfate: A Tale of Protecting Resorcylic Acid Lactones for Regiocontrolled Conjugation. Beilstein Journal of Organic Chemistry, 10, 1129–1134. https://doi.org/10.3762/bjoc.10.112 ( reposiTUm)
Fruhmann, P., Skrinjar, P., Weber, J., Mikula, H., Warth, B., Sulyok, M., Krska, R., Adam, G., Rosenberg, E., Hametner, C., & Fröhlich, J. (2014). Sulfation of deoxynivalenol, its acetylated derivatives, and T2-toxin. Tetrahedron, 70(34), 5260–5266. https://doi.org/10.1016/j.tet.2014.05.064 ( reposiTUm)
Fruhmann, P., Weigl-Pollack, T., Mikula, H., Wiesenberger, G., Adam, G., Varga, E., Berthiller, F., Krska, R., Hametner, C., & Fröhlich, J. (2014). Methylthiodeoxynivalenol (MTD): Insight into chemistry, structure and toxicity of thia-Michael adducts of trichothecenes. Organic and Biomolecular Chemistry, 12(28), 5144. https://doi.org/10.1039/c4ob00458b ( reposiTUm)
Walravens, J., Mikula, H., Rychlik, M., Asam, S., Ediage, E. N., Di Mavungu, J. D., Van Landschoot, A., Vanhaecke, L., & De Saeger, S. (2014). Development and validation of an ultra-high-performance liquid chromatography tandem mass spectrometric method for the simultaneous determination of free and conjugated Alternaria toxins in cereal-based foodstuffs. Journal of Chromatography A, 1372, 91–101. https://doi.org/10.1016/j.chroma.2014.10.083 ( reposiTUm)
Denk, C., Svatunek, D., Filip, T., Wanek, T., Lumpi, D., Fröhlich, J., Kuntner, C., & Mikula, H. (2014). Development of a 18F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 9655–9659. http://hdl.handle.net/20.500.12708/158024 ( reposiTUm)
Mikula, H., Svatunek, D., Skrinjar, P., Horkel, E., Hametner, C., & Fröhlich, J. (2014). DFTstudy of the Lewis acid mediated synthesis of 3-acyltetramic acids. Journal of Molecular Modeling, 20(2181). https://doi.org/10.1007/s00894-014-2181-0 ( reposiTUm)
Fruhmann, P., Mikula, H., Wiesenberger, G., Varga, E., Lumpi, D., Stöger, B., Häubl, G., Lemmens, M., Berthiller, F., Krska, R., Adam, G., Hametner, C., & Fröhlich, J. (2014). Isolation and Structure Elucidation of Pentahydroxyscirpene, a Trichothecene Fusarium Mycotoxin. Journal of Natural Products, 77(1), 188–192. https://doi.org/10.1021/np4008365 ( reposiTUm)
Mikula, H., Sohr, B., Skrinjar, P., Weber, J., Hametner, C., Berthiller, F., Krska, R., Adam, G., & Fröhlich, J. (2013). Sulfation of ß-resorcylic acid esters - first synthesis of zearalenone-14-sulfate. Tetrahedron Letters, 54(25), 3290–3293. https://doi.org/10.1016/j.tetlet.2013.04.059 ( reposiTUm)
Weber, J., Mikula, H., Fruhmann, P., Hametner, C., Varga, E., Berthiller, F., Krska, R., & Fröhlich, J. (2013). Gentiobiosylation of β-Resorcylic Acid Esters and Lactones: First Synthesis and Characterization of Zearalenone-14-β,ᴅ-Gentiobioside. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 24(14), 1830–1834. https://doi.org/10.1055/s-0033-1339338 ( reposiTUm)
Mikula, H., Weber, J., Lexmüller, S., Bichl, G., Schwartz, H., Varga, E., Berthiller, F., Hametner, C., Krska, R., & Fröhlich, J. (2013). Simultaneous preparation of α/β-zearalenol glucosides and glucuronides. Carbohydrate Research, 373, 59–63. https://doi.org/10.1016/j.carres.2013.03.002 ( reposiTUm)
Mikula, H., Matscheko, D., Schwarz, M., Hametner, C., & Fröhlich, J. (2013). Improved and large-scale synthesis of different protected D-glucuronals. Carbohydrate Research, 370, 19–23. https://doi.org/10.1016/j.carres.2013.01.007 ( reposiTUm)
Mikula, H., Skrinjar, P., Sohr, B., Ellmer, D., Hametner, C., & Fröhlich, J. (2013). Total synthesis of masked Alternaria mycotoxins - sulfates and glucosides of alternariol (AOH) and alternariol-9-methyl ether (AME). Tetrahedron, 69(48), 10322–10330. https://doi.org/10.1016/j.tet.2013.10.008 ( reposiTUm)
Mikula, H., Horkel, E., Hans, P., Hametner, C., & Fröhlich, J. (2013). Structure and tautomerism of tenuazonic acid - A synergetic computational and spectroscopic approach. Journal of Hazardous Materials, 250–251, 308–317. https://doi.org/10.1016/j.jhazmat.2013.02.006 ( reposiTUm)
Mikula, H., Hametner, C., & Fröhlich, J. (2013). Zearalenone mimics: Synthesis of (E)-6-(1-alkenyl)-substituted β-resorcylic acid esters. Synthetic Communications, 43(14), 1939–1946. https://doi.org/10.1080/00397911.2012.681827 ( reposiTUm)
Mikula, H., Svatunek, D., Lumpi, D., Glöcklhofer, F., Hametner, C., & Fröhlich, J. (2013). Practical and Efficient Large-Scale Preparation of Dimethyldioxirane. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 17(2), 313–316. https://doi.org/10.1021/op300338q ( reposiTUm)
Mikula, H., Hametner, C., Berthiller, F., Warth, B., Krska, R., Adam, G., & Fröhlich, J. (2012). Fast and reproducible chemical synthesis of zearalenone-14-β,D-glucuronide. World Mycotoxin Journal, 5(3), 289–296. https://doi.org/10.3920/wmj2012.1404 ( reposiTUm)
Warth, B., Sulyok, M., Fruhmann, P., Mikula, H., Berthiller, F., Schuhmacher, R., Hametner, C., Abia, W. A., Adam, G., Fröhlich, J., & Krska, R. (2012). Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins. Rapid Communications in Mass Spectrometry, 26, 1533–1540. http://hdl.handle.net/20.500.12708/164681 ( reposiTUm)
Pfeiffer, E., Hildebrand, A., Mikula, H., & Metzler, M. (2010). Glucuronidation of zearalenone, zeranol and four metabolites in vitro: Formation of glucuronides by various microsomes and human UDP-glucuronosyltransferase isoforms. Molecular Nutrition & Food Research, 54(10), 1468–1476. https://doi.org/10.1002/mnfr.200900524 ( reposiTUm)

Beiträge in Tagungsbänden

Lenz, A., Meindl, B., Holzer, B., & Mikula, H. (2024). Tailoring Peptide Nucleic Acids for Advanced Antisense Therapeutics. In Biobased Chemistry & Technology: Chemietage 2024 Book of Abstracts (pp. 168–168). ( reposiTUm)
Mikula, H. (2023). Next-Level Chemical Tools for Bioorthogonal Click-to-Release. In CLINAM 2023 : Abstracts, Speakers (pp. 106–106). ( reposiTUm)
Houszka, N., Kuba, W., Sohr, B., Wilkovitsch, M., & Mikula, H. (2019). Intracellular Retargeting Via Bioorthogonal Substitution. In 18. Österreichische Chemietage (p. 1). http://hdl.handle.net/20.500.12708/50695 ( reposiTUm)
Sohr, B., Kuba, W., Houszka, N., & Mikula, H. (2019). Towards Targeted Drug Delivery Using Click-To-Release Chemistry. In 18. Österreichische Chemietage (p. 1). http://hdl.handle.net/20.500.12708/50674 ( reposiTUm)
Kuba, W., Houszka, N., Wanek, T., & Mikula, H. (2019). Boosting Bioorthogonal Click-Torelease Chemistry By Intramolecular Control And Acceleration Of Post-Click Tautomerization. In 18. Österreichische Chemietage (p. 1). http://hdl.handle.net/20.500.12708/50720 ( reposiTUm)
Kronister, S., Miller, M., & Mikula, H. (2019). Double-Targeted Bioorthogonal Nano-Prodrug Activation Inside Tumor Cells. In 8th Chemical Protein Synthesis Meeting (p. 1). http://hdl.handle.net/20.500.12708/50718 ( reposiTUm)
Wilkovitsch, M., Svatunek, D., & Mikula, H. (2019). Highly reactive dienophiles for bioorthogonal tetrazine ligations. In 21th European Symposium on Organic Chemistry (p. 1). http://hdl.handle.net/20.500.12708/50719 ( reposiTUm)
Svatunek, D., Wilkovitsch, M., Hartmann, L., Houk, K., & Mikula, H. (2019). Distortion controlled reactivity of 2-Pyridyl-1,2,4,5-tetrazines. In 46th National Organic Chemistry Symposium (p. 1). http://hdl.handle.net/20.500.12708/50717 ( reposiTUm)
Wilkovitsch, M., Svatunek, D., & Mikula, H. (2019). Highly Reactive Dienophiles For Bioorthogonal Tetrazine Ligations. In 18. Österreichische Chemietage (p. 1). http://hdl.handle.net/20.500.12708/50724 ( reposiTUm)
Skrinjar, P., Schwarz, M., Mechtler, T. P., Fröhlich, J., Greber-Platzer, S., Kasper, D., & Mikula, H. (2017). Highly Efficient Enzyme Substrates For Diagnosis Of Mucopolysaccharidosis. In 17th Blue Danube Symposium on Heterocyclic Chemistry (p. 117). http://hdl.handle.net/20.500.12708/50108 ( reposiTUm)
Weber, J., Svatunek, D., Tegl, G., Krauter, S., Hametner, C., Kosma, P., Fröhlich, J., & Mikula, H. (2017). 2-O-Benzyloxycarbonyl Protected Glycosides as New Tools for Trans- Glycosylation. In 17. Österreichische Chemietage 2017 (p. 1). http://hdl.handle.net/20.500.12708/50111 ( reposiTUm)
Kronister, S., Denk, C., Svatunek, D., & Mikula, H. (2017). Kinetics Of Amino And Amido Tetrazines In Bioorthogonal Ligations. In 17th Blue Danube Symposium on Heterocyclic Chemistry (p. 89). http://hdl.handle.net/20.500.12708/50109 ( reposiTUm)
Mikula, H. (2017). 1,2,4,5-Tetrazines as versatile bioorthogonal tools for in vivo chemistry. In 17th Blue Danube Symposium on Heterocyclic Chemistry (p. 32). http://hdl.handle.net/20.500.12708/50106 ( reposiTUm)
Kuba, W., Wanek, T., Denk, C., & Mikula, H. (2017). Bioorthogonal Click-to-Release Chemistry for Rapid Radiolabeling. In 17. Österreichische Chemietage 2017 (p. 1). http://hdl.handle.net/20.500.12708/50095 ( reposiTUm)
Kronister, S., Svatunek, D., & Mikula, H. (2017). Synthesis and kinetics of novel release-trans-cyclooctenes. In 17. Österreichische Chemietage 2017 (p. 1). http://hdl.handle.net/20.500.12708/50094 ( reposiTUm)
Skrinjar, P., Schwarz, M., Mechtler, T. P., Fröhlich, J., Greber-Platzer, S., Kasper, D., & Mikula, H. (2017). Synthesis Of Mucopolysaccharidosis Enzyme Assay Substrates By Click Chemistry. In 17. Österreichische Chemietage 2017 (p. 1). http://hdl.handle.net/20.500.12708/50002 ( reposiTUm)
Wilkovitsch, M., Svatunek, D., & Mikula, H. (2017). Highly Reactive Dienophiles for Bioorthogonal Tetrazine Ligations. In 17. Österreichische Chemietage 2017 (p. 1). http://hdl.handle.net/20.500.12708/50034 ( reposiTUm)
Denk, C., Wilkovitsch, M., Wanek, T., Kuntner, C., Svatunek, D., & Mikula, H. (2017). Radiolabeled 1,2,4,5-Tetrazines As Bioorthogonal Imaging Tools. In 10th Joint Meeting on Medicinal Chemistry - Book of Abstracts (p. 103). http://hdl.handle.net/20.500.12708/50110 ( reposiTUm)
Mikula, H. (2017). Pretargeted Prodrug Activation Through Bioorthogonal Elimination. In 10th Joint Meeting on Medicinal Chemistry - Book of Abstracts (p. 57). http://hdl.handle.net/20.500.12708/50105 ( reposiTUm)
Svatunek, D., Haider, M., & Mikula, H. (2017). Highly Reactive Dienophiles For Bioorthogonal Tetrazine Ligations. In 10th Joint Meeting on Medicinal Chemistry - Book of Abstracts (p. 223). http://hdl.handle.net/20.500.12708/50086 ( reposiTUm)
Sohr, B., Denk, C., Wanek, T., & Mikula, H. (2017). Development Of Bioorthogonal 2-Nitroimidazole Based Hypoxia Sensitive Probes. In 10th Joint Meeting on Medicinal Chemistry - Book of Abstracts (p. 215). http://hdl.handle.net/20.500.12708/50075 ( reposiTUm)
Bintinger, J., Cernetic, N., Bittner, R., Sauer, M., Foelske-Schmitz, A., Holzweber, M., Schiros, T., Nordlund, D., Svatunek, D., Ma, H., Hoffmann, H., Fröhlich, J., Jen, A., & Mikula, H. (2016). Using click chemistry for a facile approach towards self-assembled monolayer field-effect transistors (SAMFETs): A new versatile approach for sensing. In Bioelectrochemistry And More - 2016, Abstract Book. Bioelectrochemistry And More - 2016, Wiener Neustadt, Austria. http://hdl.handle.net/20.500.12708/49731 ( reposiTUm)
Haider, M., Fruhmann, P., Weber, J., Skrinjar, P., Hametner, C., Mikula, H., Fröhlich, J., & Adam, G. (2016). Optimized synthesis of butenolide: a journey towards isotope labelled butenolide. In Conference Abstracts (p. 92). http://hdl.handle.net/20.500.12708/49714 ( reposiTUm)
Weber, J., Fruhmann, P., Hametner, C., Schiessl, A., Häubl, G., Fröhlich, J., & Mikula, H. (2016). Optimized Synthesis of Deoxynivalenol-15-ß-D-glycosides. In Conference Abstracts (p. 151). http://hdl.handle.net/20.500.12708/49716 ( reposiTUm)
Houszka, N., Svatunek, D., Denk, C., Hametner, C., Fröhlich, J., Allmaier, G., & Mikula, H. (2016). Reactivity Of Secondary And Tertiary Azides In The Strain-Promoted Alkyne Azide Cycloaddition. In ECHC 2016 - XXVII European Colloquium on Heterocyclic Chemistry (p. 205). http://hdl.handle.net/20.500.12708/49737 ( reposiTUm)
Puntscher, H., Warth, B., Skrinjar, P., Ellmer, D., Mikula, H., & Marko, D. (2016). Development and first applications of an LC-ESI-MS/MS multi-method for the quantification of Alternaria toxins. In Conference Abstracts (p. 121). http://hdl.handle.net/20.500.12708/49353 ( reposiTUm)
Walravens, J., Mikula, H., Rychlik, M., Asam, S., Di Mavungu, J. D., Jacxsens, L., Lachat, C., Van Landschoot, A., Vanhaecke, L., & De Saeger, S. (2015). (Modified) Alternaria mycotoxins in foodstuffs: Occurrence and influence of food processing. In Conference Abstracts (p. 48). http://hdl.handle.net/20.500.12708/48910 ( reposiTUm)
Tiessen, C., Pahlke, G., Mikula, H., Fröhlich, J., & Marko, D. (2015). Impact of phase I metabolism on cellular uptake, oxidative stress and genotoxicity of alternariol and its monomethyl ether. In Conference Abstracts (p. 52). http://hdl.handle.net/20.500.12708/48911 ( reposiTUm)
Weber, J., Mikula, H., Fruhmann, P., Hametner, C., & Fröhlich, J. (2015). Mycotoxin-Conjugates as Reference Materials for Environmental Monitoring. In Book of Abstracts (pp. 94–95). Richard Zemann. http://hdl.handle.net/20.500.12708/49143 ( reposiTUm)
Lexmüller, S., Mikula, H., & Fröhlich, J. (2015). Designing Novel Fluorogenic Probes for Rapid Online Detection of Bacteria in Water. In Book of Abstracts (pp. 98–99). Richard Zemann. http://hdl.handle.net/20.500.12708/49144 ( reposiTUm)
Bintinger, J., Bittner, R., Yang, S., Bethge, O., Hoffmann, H., Kröber, T., Mikula, H., Foelske-Schmitz, A., Hradil, K., Knoll, W., Kymissis, I., & Fröhlich, J. (2015). Self-assembled monolayer field-effect transistors (SAMFETs): A new synthetic approach for sensing applications. In Fπ-12 Program with links to Abstracts (web page). 12#^{th} International Symposium on Functional #pi-Electron Systems, University of Washington, Seattle, USA, Non-EU. http://depts.washington.edu/uwconf/fpi12/fpi12_abstracts.html. http://hdl.handle.net/20.500.12708/49164 ( reposiTUm)
Bintinger, J., Bittner, R., Yang, S., Hoffmann, H., Kröber, T., Mikula, H., Knoll, W., Kymissis, I., & Fröhlich, J. (2015). Self-Assembled Monolayer Field-Effect Transistors (samfets): A New Synthetic Approach For Sensing Applications. In Bioelectrochemistry And More. Bioelectrochemistry And More, Wiener Neustadt, Austria. http://hdl.handle.net/20.500.12708/49166 ( reposiTUm)
Weber, J., Fruhmann, P., Hametner, C., Fröhlich, J., Mikula, H., Schiessl, A., & Häubl, G. (2015). Synthesis of Deoxynivalenol-15-ß,D-glucoside. In Conference Abstracts (p. 123). http://hdl.handle.net/20.500.12708/48915 ( reposiTUm)
Tiessen, C., Gehrke, H., Ellmer, D., Mikula, H., Fröhlich, J., & Marko, D. (2014). Genotoxicity of 4-hydroxyalternariol and its methyl ether in comparison to the parent substances alternariol and alternariol monomethyl ether. In Conference Abstracts (p. 100). http://hdl.handle.net/20.500.12708/48572 ( reposiTUm)
Walravens, J., Mikula, H., Rychlik, M., Asam, S., Diana Di Mavungu, J., Van Landschoot, A., Vanhaecke, L., & De Saeger, S. (2014). Occurrence of (masked) Alternaria toxins - A survey in foodstuffs commercially available on the Belgian market. In Conference Abstracts (p. 130). http://hdl.handle.net/20.500.12708/48574 ( reposiTUm)
Fruhmann, P., Skrinjar, P., Weber, J., Mikula, H., Wiesenberger, G., Fröhlich, J., Hametner, C., & Adam, G. (2014). Large scale synthesis and characterization of deoxynivalenol-3-sulfate, a major chicken metabolite. In Conference Abstracts (p. 106). http://hdl.handle.net/20.500.12708/48573 ( reposiTUm)
Weigl-Pollack, T., Fruhmann, P., Mikula, H., Hametner, C., Wiesenberger, G., Varga, E., Berthiller, F., Krska, R., Fröhlich, J., & Adam, G. (2013). S-Methyl-DON: Synthesis, Structure, Determination, and Toxicity Tests of a Novel Mycotoxin Conjugate. In Conference Abstracts (p. 203). http://hdl.handle.net/20.500.12708/48168 ( reposiTUm)
Ellmer, D., Mikula, H., Hametner, C., Tiessen, C., Gehrke, H., Marko, D., & Fröhlich, J. (2013). Total Synthesis of Phase I Metabolites of Alternariol (AOH) and Alternariol-9-methyl ether (AME). In Conference Abstracts (p. 154). http://hdl.handle.net/20.500.12708/48167 ( reposiTUm)
Weber, J., Fruhmann, P., Mikula, H., Hametner, C., & Fröhlich, J. (2013). Synthesis of Zearalenone-14-ß-diglucoside. In Conference Abstracts (p. 126). http://hdl.handle.net/20.500.12708/48166 ( reposiTUm)
Skrinjar, P., Mikula, H., Hametner, C., & Fröhlich, J. (2013). Total Synthesis of AOH- and AME-ß-D-Glucosides. In Conference Abstracts (p. 124). http://hdl.handle.net/20.500.12708/48165 ( reposiTUm)
Walravens, J., Mikula, H., Rychlik, M., Asam, S., Diana Di Mavungu, J., Van Landschoot, A., Vanhaecke, L., & De Saeger, S. (2013). Development and validation of an LC-MS/MS method for the simultaneous determination of free and conjugated Alternaria toxins in cereal-based foodstuffs. In Conference Abstracts (p. 78). http://hdl.handle.net/20.500.12708/48407 ( reposiTUm)
Tiessen, C., Gehrke, H., Ellmer, D., Mikula, H., Fröhlich, J., & Marko, D. (2013). Genotoxic properties of Alternariol and its phase I metabolite 4-OH-Alternariol. In Conference Abstracts (p. 70). http://hdl.handle.net/20.500.12708/48405 ( reposiTUm)
Denk, C., Eilenberger, G., Linert, W., Lumpi, D., Mikula, H., Hametner, C., & Fröhlich, J. (2013). Kinetics of Tetrazine Ligations: From Organic to Biological Media. In Abstracts Book (p. 61). http://hdl.handle.net/20.500.12708/48203 ( reposiTUm)
Eilenberger, G., Lumpi, D., Denk, C., Mikula, H., Hametner, C., & Fröhlich, J. (2013). ATR-IR Inline Monitoring of Strain Promoted Alkyne-Azide Cycloadditions in Biological Media. In Abstracts Book (p. 135). http://hdl.handle.net/20.500.12708/48204 ( reposiTUm)
Tegl, G., Krauter, S., Svatunek, D., Mikula, H., Hametner, C., & Fröhlich, J. (2013). Development of Novel Thioglycosyldonors for the Preparation of Natural Product Glucosides. In Abstracts Book (p. 96). http://hdl.handle.net/20.500.12708/48205 ( reposiTUm)
Svatunek, D., Mikula, H., Hametner, C., & Fröhlich, J. (2013). Advanced Synthesis of Glycoconjugates and Oligosaccharides. In Abstracts Teil 2 (pp. 187–189). http://hdl.handle.net/20.500.12708/48443 ( reposiTUm)
Krska, R., Kluger, B., Büschl, C., Warth, B., Sulyok, M., Fruhmann, P., Berthiller, F., Schuhmacher, R., Hametner, C., Mikula, H., Fröhlich, J., Nagl, V., Lemmens, M., Schwartz, H., & Adam, G. (2013). New Insights into the Metabolization of Deoxynivalenol in Plants and Humans and Their Significance for the Consumer. In Book of Abstracts (p. 57). http://hdl.handle.net/20.500.12708/48418 ( reposiTUm)
Weigl-Pollack, T., Wiesenberger, G., Fruhmann, P., Hametner, C., Mikula, H., Kluger, B., Schuhmacher, R., Krska, R., Fröhlich, J., & Adam, G. (2013). S-Methyl-DON: Chemical Synthesis and Toxicity of a Novel Deoxynivalenol Metabolite. In Book of Abstracts (p. 184). http://hdl.handle.net/20.500.12708/48421 ( reposiTUm)
Krska, R., Kluger, B., Büschl, C., Warth, B., Sulyok, M., Fruhmann, P., Berthiller, F., Schuhmacher, R., Hametner, C., Mikula, H., Fröhlich, J., Nagl, V., Lemmens, M., Schwartz, H., & Adam, G. (2013). Mycotoxins and Their Metabolites: From Targeted to Untargeted Analysis. In Book of Abstracts (p. 128). http://hdl.handle.net/20.500.12708/48432 ( reposiTUm)
Weigl-Pollack, T., Wiesenberger, G., Fruhmann, P., Mikula, H., Hametner, C., Kluger, B., Schuhmacher, R., Krska, R., Fröhlich, J., & Adam, G. (2013). S-Methyl-DON: Chemical synthesis and toxicity of a novel DON metabolite. In EFS12 Programme & Abstracts (p. 193). http://hdl.handle.net/20.500.12708/48431 ( reposiTUm)
Varga, E., Fruhmann, P., Wiesenberger, G., Hametner, C., Mikula, H., Häubl, G., Krska, R., Adam, G., Lemmens, M., Fröhlich, J., & Berthiller, F. (2013). Pentahydroxyscirpene - Detection, Isolation, Structure Elucidation, and Toxicity Assessment of a New Mycotoxin. In Book of Abstracts (p. 186). http://hdl.handle.net/20.500.12708/48422 ( reposiTUm)
Kovalsky Paris, M. P., Schweiger, W., Wiesenberger, G., Torres Acosta, J. A., Michlmayr, H., Newmister, S., Lemmens, M., Malachova, A., Shin, S., Muehlbauer, G. J., Weigl-Pollack, T., Fruhmann, P., Mikula, H., Hametner, C., Kluger, B., Schuhmacher, R., Krska, R., Fröhlich, J., Rayment, I., … Adam, G. (2013). Inactivation of Fusarium Mycotoxins in Planta. In Book of Abstracts (p. 82). http://hdl.handle.net/20.500.12708/48419 ( reposiTUm)
Kovalsky Paris, M. P., Schweiger, W., Wiesenberger, G., Torres Acosta, J. A., Michlmayr, H., Newmister, S., Lemmens, M., Malachova, A., Shin, S., Muehlbauer, G. J., Weigl-Pollack, T., Fruhmann, P., Mikula, H., Hametner, C., Kluger, B., Schuhmacher, R., Krska, R., Fröhlich, J., Rayment, I., … Adam, G. (2013). In planta Inactivation of Fusarium Mycotoxins. In EFS12 Programme & Abstracts (p. 74). http://hdl.handle.net/20.500.12708/48430 ( reposiTUm)
Fruhmann, P., Hametner, C., Wiesenberger, G., Varga, E., Mikula, H., Krska, R., Adam, G., Lemmens, M., Fröhlich, J., & Berthiller, F. (2012). Pentahydroxyscirpene - Detection, Isolation, and Structure Elucidation of a New Mycotoxin. In Conference Abstracts (p. 19). http://hdl.handle.net/20.500.12708/48022 ( reposiTUm)
Weber, J., Fruhmann, P., Mikula, H., Hametner, C., & Fröhlich, J. (2012). Towards the Synthesis of Late Phase II Metabolites of Mycotoxins. In Conference Abstracts (p. 88). http://hdl.handle.net/20.500.12708/48024 ( reposiTUm)
Ellmer, D., Mikula, H., Hametner, C., & Fröhlich, J. (2012). Total Synthesis of Phase I Metabolites of Alternariol (AOH) and Alternariol-9-methyl ether (AME). In Conference Abstracts (p. 87). http://hdl.handle.net/20.500.12708/48023 ( reposiTUm)
Svatunek, D., Knittl, E., Weigl-Pollack, T., Mikula, H., Hametner, C., & Fröhlich, J. (2012). Siprops - A Set of New Semiorthogonal Protecting Groups. In 26#^{th} International Carbohydrate Symposium (p. 1). http://hdl.handle.net/20.500.12708/48066 ( reposiTUm)
Mikula, H., Hametner, C., Fröhlich, J., Berthiller, F., Krska, R., & Adam, G. (2011). Advanced synthesis of masked mycotoxins - methods and applications. In 33. Mycotoxin-Workshop - Conference Abstracts (p. 28). http://hdl.handle.net/20.500.12708/47718 ( reposiTUm)
Mikula, H., Hametner, C., & Fröhlich, J. (2011). Benzyloxycarbonyl protected heterocyclic thioglucosides for the diastereoselective glucosylation of natural products. In Book of Abstracts - 14th Blue Danube Symposium on Heterocyclic Chemistry (p. 90). Vydavatel’stvo STU - Publishing House of Slovak University of Technology. http://hdl.handle.net/20.500.12708/47713 ( reposiTUm)
Puntscher, H., Mikula, H., Hametner, C., & Fröhlich, J. (2011). Advanced synthesis of malonylglucosylated mycotoxins. In 33. Mycotoxin-Workshop - Conference Abstracts (p. 67). http://hdl.handle.net/20.500.12708/47720 ( reposiTUm)
Lexmüller, S., Mikula, H., Hametner, C., & Fröhlich, J. (2011). Synthesis of zearalenol mimics and masked mycotoxins. In 33. Mycotoxin-Workshop - Conference Abstracts (p. 59). http://hdl.handle.net/20.500.12708/47719 ( reposiTUm)
Krauter, S., Mikula, H., Hametner, C., & Fröhlich, J. (2011). Synthesis of masked Alternaria toxins. In 33. Mycotoxin-Workshop - Conference Abstracts (p. 56). http://hdl.handle.net/20.500.12708/47715 ( reposiTUm)
Sohr, B., Mikula, H., Hametner, C., & Fröhlich, J. (2011). Advanced synthesis of mycotoxin sulfates. In 33. Mycotoxin-Workshop - Conference Abstracts (p. 74). http://hdl.handle.net/20.500.12708/47721 ( reposiTUm)
Eilenberger, G., Mikula, H., Hametner, C., & Fröhlich, J. (2011). Towards the synthesis of polybioside. In Book of Abstracts - 14th Blue Danube Symposium on Heterocyclic Chemistry (p. 52). Vydavatel’stvo STU - Publishing House of Slovak University of Technology. http://hdl.handle.net/20.500.12708/47712 ( reposiTUm)
Mikula, H., Hametner, C., & Fröhlich, J. (2011). New Methods for the synthesis of glycoconjugates and application to masked mycotoxins. In Abstract Booklet. 2011 Einsteins in the City, New York, USA, Non-EU. http://hdl.handle.net/20.500.12708/47711 ( reposiTUm)
Mikula, H., Hametner, C., & Fröhlich, J. (2011). SiProps - New protecting groups for carbohydrate synthesis. In Eurocarb - Abstract (p. 429). http://hdl.handle.net/20.500.12708/47708 ( reposiTUm)
Warth, B., Sulyok, M., Fruhmann, P., Mikula, H., Berthiller, F., Schuhmacher, R., Hametner, C., Fröhlich, J., & Krska, R. (2011). Biomarkers of exposure to deoxynivalenol and zearalenone: Method development and its application to human urine samples. In 33. Mycotoxin-Workshop - Conference Abstracts (p. 79). http://hdl.handle.net/20.500.12708/47722 ( reposiTUm)
Svatunek, D., Mikula, H., Hametner, C., & Fröhlich, J. (2010). Novel glucosyl donors in the synthesis of masked mycotoxins. In 32#^{nd} Mycotoxin Workshop - Abstracts & Programme (p. 116). http://hdl.handle.net/20.500.12708/47433 ( reposiTUm)
Schwarz, M., Mikula, H., Hametner, C., & Fröhlich, J. (2010). New methods for the synthesis of mycotoxin glucuronides (part A). In 32#^{nd} Mycotoxin Workshop - Abstracts & Programme (p. 114). http://hdl.handle.net/20.500.12708/47607 ( reposiTUm)
Matscheko, D., Mikula, H., Hametner, C., & Fröhlich, J. (2010). New methods for the synthesis of mycotoxin glucuronides (part B). In 32#^{nd} Mycotoxin Workshop - Abstracts & Programme (p. 102). http://hdl.handle.net/20.500.12708/47606 ( reposiTUm)
Matscheko, D., Mikula, H., Hametner, C., & Fröhlich, J. (2010). Synthesis of fully benzyl- and silyl-protected glucuronals as intermediates for new diastereoselective glucuronyl donors. In Proceedings (pp. 257–258). http://hdl.handle.net/20.500.12708/47612 ( reposiTUm)
Svatunek, D., Mikula, H., Hametner, C., & Fröhlich, J. (2010). Large scale synthesis of dimethyldioxirane (DMDO) and its application in the development of new glycosylation reagents. In Proceedings (pp. 197–198). http://hdl.handle.net/20.500.12708/47611 ( reposiTUm)
Mikula, H., Karl, H. P., Kölsch, H.-P., Hametner, C., & Fröhlich, J. (2010). Model Structures for the Mycotoxin Zearalenone as Mimics in Metabolite Synthesis. In Proceedings (pp. 195–196). http://hdl.handle.net/20.500.12708/47613 ( reposiTUm)
Warth, B., Fruhmann, P., Mikula, H., Berthiller, F., Schuhmacher, R., Gilbert, J., Hametner, C., Sulyok, M., Fröhlich, J., & Krska, R. (2010). lucuronide Conjugates of Deoxynivalenol and Zearalenone in Human Urine: A Novel LC-MS/MS Approach. In 32#^{nd} Mycotoxin Workshop - Abstracts & Programme (p. 72). http://hdl.handle.net/20.500.12708/47609 ( reposiTUm)
Schweiger, W., Berthiller, F., Bicker, W., Schuhmacher, R., Krska, R., Mikula, H., Hametner, C., & Adam, G. (2009). Formation of the Biomarker Zearalenone-4-O-Glucuronide by Human UDP-Glucuronosyltransferases and Engineered Yeast. In Proceedings of the 2009 National Fusarium Head Blight Forum (p. 11). http://hdl.handle.net/20.500.12708/47396 ( reposiTUm)
Schweiger, W., Berthiller, F., Bicker, W., Schuhmacher, R., Krska, R., Fruhmann, P., Mikula, H., Hametner, C., Fröhlich, J., & Adam, G. (2009). Phase II detoxification of the Fusarium mycotoxins deoxynivalenol and zearalenone by human UDP-glucuronyltransferases in vitro and in genetically engineered yeast. In ISM Conference 2009 - Worldwide Mycotoxin Reduction in Food and Feed Chains (p. 142). http://hdl.handle.net/20.500.12708/47397 ( reposiTUm)
Mikula, H., Hametner, C., Fröhlich, J., Krska, R., & Adam, G. (2008). Regioselective Synthesis of Zearalenone-4-glucuronide. In 30#^{th} Mycotoxin Workshop 2008, Conference Abstracts (p. 148). http://hdl.handle.net/20.500.12708/46170 ( reposiTUm)
Mikula, H., Karl, H. P., Klösch, B., Hametner, C., & Fröhlich, J. (2008). Model Structures for the Mycotoxin Zearalenone as Mimics in Metabolite Synthesis. In Junior Scientists Conference 2008 Proceedings (pp. 195–196). http://hdl.handle.net/20.500.12708/46221 ( reposiTUm)
Mikula, H., Hametner, C., Fröhlich, J., Schuhmacher, R., & Adam, G. (2007). Regioselective Glucuronidation on the Example of the Fusarium Mycotoxin Zearalenone Supported by Model Structures and Computational Chemistry. In Einsteins in the CITY2, Abstracts. Einsteins in the City 2, City College of New York, New York City, USA, Non-EU. http://hdl.handle.net/20.500.12708/46018 ( reposiTUm)

Beiträge in Büchern

Kuba, W., Wilkovitsch, M., Carlson, J. C. T., & Mikula, H. (2021). 7 Tetrazine-Based Cycloadditions in Click Chemistry. In Click Chemistry. Thieme. https://doi.org/10.1055/sos-sd-235-00300 ( reposiTUm)
Mikula, H., Blaukopf, M., Sixta, G., Stanetty, C., & Kosma, P. (2014). Synthesis of Ammonium 3-Deoxy-D-manno-oct-2-ulopyranosylonate (Ammonium Kdo). In G. van der Marel & J. Codee (Eds.), Carbohydrate Chemistry: Proven Synthetic Methods, Volume 2 (pp. 207–211). CRC Press. http://hdl.handle.net/20.500.12708/28124 ( reposiTUm)

Präsentationen

Meindl, B., Lenz, A., Holzer, B., & Mikula, H. (2024, July 11). Development of Advanced Peptide Nucleic Acids for RNA-Targeting [Poster Presentation]. 9th EuChemS Chemistry Congress 2024, Dublin, Ireland. http://hdl.handle.net/20.500.12708/211004 ( reposiTUm)
Kratena, N., Demuth, T., Denk, C., Mairinger, S., Langer, O., & Mikula, H. (2024, July 31). Synthesis of a modified ACE2-inhibitor for 18F, 11C and 124I isotopic radiolabelling and PET tracer development [Poster Presentation]. ACS Publications Symposium: Catalysis for Organic Synthesis, Vienna, Austria. http://hdl.handle.net/20.500.12708/208509 ( reposiTUm)
Kratena, N., Demuth, T., Denk, C., Mairinger, S., Langer, O., & Mikula, H. (2024, July 3). Synthesis of a modified ACE2-inhibitor for 18F, 11C and 124I isotopic radiolabelling and PET tracer development [Poster Presentation]. 18th Belgian Organic Synthesis Symposium (BOSS XVIII ), Liege, Belgium. http://hdl.handle.net/20.500.12708/208507 ( reposiTUm)
Lenz, A., Meindl, B., Holzer, B., & Mikula, H. (2023, December 5). Tailoring Peptide Nucleic Acids for Enhanced RNA-Targeting [Poster Presentation]. 12th Austrian Peptide Symposium, Wien, Austria. ( reposiTUm)
Mikula, H. (2023, March 8). Next-level chemical tools for ultrafast bioorthogonal bond-cleavage [Conference Presentation]. VI RSEQ Chemical Biology Group Meeting (ChemBioVI) 2023, Valencia, Spain. ( reposiTUm)
Mikula, H. (2023, August 17). Next-level click-triggered bioorthogonal bond-cleavage [Keynote Presentation]. Annual Meeting of the Danish Chemical Society 2023, Copenhagen, Denmark. ( reposiTUm)
Meindl, B., Lenz, A., Holzer, B., & Mikula, H. (2023, May). Modified Peptide Nucleic Acids for RNA-Targeting [Poster Presentation]. ELRIG Therapeutic OLIGO & European Chemical Biology Symposium 2023, Gothenburg, Sweden. ( reposiTUm)
Herrmann, B., Sohr, B., Legado, A., Schnöll, S., Reindl, S., Goldeck, M., & Mikula, H. (2023, December 5). STOPTAC: Scissile Turn-Off Proteolysis Targeting Chimeras [Poster Presentation]. 12th Austrian Peptide Symposium (2023), Wien, Austria. http://hdl.handle.net/20.500.12708/193427 ( reposiTUm)
Meindl, B., Hipfinger, I., Holzer, B., & Mikula, H. (2022, September 20). Design and Synthesis of γ-miniPEG-PNA for RNA-Targeting [Poster Presentation]. 19. Österreichische Chemietage, Wien, Austria. http://hdl.handle.net/20.500.12708/152395 ( reposiTUm)
Mikula, H. (2022, June 1). Exit the Cube: Next-Level Chemical Tools for Ultrafast Bioorthogonal Bond-Cleavage [Conference Presentation]. Peptide Chemistry and Chemical Biology Symposium, Hungary. ( reposiTUm)
Pressler, M., Denk, C., Scheibelreiter, V., Kuba, W., & Mikula, H. (2022, April 8). PREPARATION OF AN AC-225 GENERATOR FROM AN OLD U-232/233 SAMPLE AND SUCCESSFUL AC-225 RADIOLABELING OF A NOVEL DOTA 1,2,4,5-TETRAZINE DERIVATIVE [Conference Presentation]. Twelfth International Conference on Methods and Applications of Radioanalytical Chemistry, KAILUA-KONA, HAWAII, United States of America (the). ( reposiTUm)
Mikula, H. (2022, February 22). Next-level chemical tools for click-triggered bioorthogonal bond-cleavage reactions [Keynote Presentation]. Thieme WebCheminar Click Chemistry, Germany. ( reposiTUm)
Mikula, H. (2022, August 29). ’Exit the Cube‘: Next-Level Chemical Tools for Ultrafast Bioorthogonal Bond-Cleavage [Conference Presentation]. EuChemS Chemistry Congress, Portugal. ( reposiTUm)
Meindl, B., Holzer, B., & Mikula, H. (2022, August 22). Design and Synthesis of y-miniPEG-PNAs for RNA-PNA hybridization [Poster Presentation]. 19th Blue Danube Symposium on Heterocyclic Chemistry, Slovakia. ( reposiTUm)
Kuba, W., Sohr, B., Schiefer, A., & Mikula, H. (2022, February 4). Boosting Bioorthogonal Bond-Cleavage Reactions of Tetrazines and trans-Cyclooctenes via Intramolecular Interactions [Conference Presentation]. 1st Blue Danube PhD Symposium, Unknown. http://hdl.handle.net/20.500.12708/177534 ( reposiTUm)
Rudatis, P., Cherevan, A., Bintinger, J., Knoll, W., Mikula, H., & Eder, D. (2019). From Graphene Biosensing to Hematite Photosensing. 34th Workshop on Novel Materials and Superconductors, Schladming, Austria. http://hdl.handle.net/20.500.12708/101259 ( reposiTUm)
Mikula, H. (2019). Exit the cube: Advancing bioorthogonal bond-cleavage reactions to the next level. 8th Chemical Protein Synthesis Meeting, Berlin, Germany. http://hdl.handle.net/20.500.12708/101358 ( reposiTUm)
Rudatis, P., Bintinger, J., Cherevan, A., Mikula, H., & Eder, D. (2018, February 14). Reducing Graphene Oxide [Poster Presentation]. 33. Workshop in Novel Materials and Superconductivity, Obertraun, Austria. ( reposiTUm)
Mikula, H. (2018). Bioorthogonal Chemistry in Nanomedicine. Nano World Cancer Day 2018, Wien, Austria. http://hdl.handle.net/20.500.12708/100998 ( reposiTUm)
Mikula, H. (2018). Bioorthogonal Chemistry in (Nano)Theranostics. BioNanoMed 2018, Graz, Austria. http://hdl.handle.net/20.500.12708/100999 ( reposiTUm)
Rosecker, V., Denk, C., Maurer, M., & Mikula, H. (2018). Development of a Hybrid-Theranostic-System. Marc Xi (2018), Hawaii, United States of America (the). http://hdl.handle.net/20.500.12708/134522 ( reposiTUm)
Sohr, B., Svatunek, D., & Mikula, H. (2018). Chemical Probes for Intracellular Hypoxia Targeting. International Chemical Biology Symposium (ICBS) 2018, Vancouver, Canada. http://hdl.handle.net/20.500.12708/100996 ( reposiTUm)
Houszka, N., Sohr, B., Sporer, E., & Mikula, H. (2018). Intracellular Bioorthogonal Cleavage. International Chemical Biology Symposium (ICBS) 2018, Vancouver, Canada. http://hdl.handle.net/20.500.12708/100997 ( reposiTUm)
Mikula, H. (2017). Bioorthogonal Diagnostic Tools for Pretargeted PET Imaging. 7th Paul Ehrlich MedChem EuroPhD Network Symposium, Vienna, Austria. http://hdl.handle.net/20.500.12708/100608 ( reposiTUm)
Bintinger, J., Sauer, M., Foelske-Schmitz, A., Kymissis, I., Cernetic, N., Jen, A., Mikula, H., & Fröhlich, J. (2017). Development of self-assembled monolayer organic electronics: A spectroscopic study. The 17th European Conference on Applications of Surface and Interface Analysis (ECASIA 17), Montpellier, France. http://hdl.handle.net/20.500.12708/81025 ( reposiTUm)
Mikula, H. (2017). Tetrazine Ligations in Pretargeted Imaging and Bioorthogonal Elimination. EuCheMS Young Investigator Workshop 2017, Köln, Germany. http://hdl.handle.net/20.500.12708/100609 ( reposiTUm)
Bintinger, J., Sauer, M., Foelske-Schmitz, A., Kymissis, I., Cernetik, N., Jen, A., Mikula, H., & Fröhlich, J. (2016). How X-ray photoelectron spectroscopy contributes to the development of organic electronics. 16th Joint Vacuum Conference (JVC-16), Portoroz, Slovenien, EU. http://hdl.handle.net/20.500.12708/80988 ( reposiTUm)
Denk, C., Duffy, M., Hermann, S., Faust, A., Svatunek, D., Fröhlich, J., Schäfers, M., & Mikula, H. (2015). Radioiodinated 1,2,4,5-Tetrazine (Radio)Synthesis and in vivo Evaluation for Therapeutic Pretargeting. World Molecular Imaging Congress 2015, Honolulu, HI, USA, Non-EU. http://hdl.handle.net/20.500.12708/99845 ( reposiTUm)
Denk, C., Mairinger, S., Stanek, J., Wanek, T., Filip, T., Svatunek, D., Fröhlich, J., Kuntner, C., & Mikula, H. (2015). Development and Evaluation of a small [11C]-Tetrazine as bioorthogonal PET Probe. World Molecular Imaging Congress 2015, Honolulu, HI, USA, Non-EU. http://hdl.handle.net/20.500.12708/99844 ( reposiTUm)
Denk, C., Svatunek, D., Filip, T., Wanek, T., Lumpi, D., Fröhlich, J., Kuntner, C., & Mikula, H. (2014). Development and Evaluation of Radiolabeled 1,2,4,5-Tetrazines: Tools for Pretargeted PET Imaging. World Molecular Imaging Congress 2014, Seoul, Korea, Non-EU. http://hdl.handle.net/20.500.12708/99853 ( reposiTUm)
Adam, G., Weigl-Pollack, T., Wiesenberger, G., Fruhmann, P., Mikula, H., Hametner, C., Kluger, B., Schuhmacher, R., Krska, R., & Fröhlich, J. (2013). Chemical Synthesis and Toxicity of the Novel DON Metabolite S-Methyl-DON. Gordon Research Conference “Mycotoxins & Phycotoxins,” Easton, MA, USA, Non-EU. http://hdl.handle.net/20.500.12708/99232 ( reposiTUm)

Berichte

Mikula, H., Svatunek, D., Sohr, B., Wilkovitsch, M., & Haider, M. (2018). Report on deliverable D3.2 - Synthesis of TCO tags with improved stability (Horizon 2020 Project ’Click-It’). http://hdl.handle.net/20.500.12708/39700 ( reposiTUm)

Multimedia & Design

Wilkovitsch, M., Kuba, W., Keppel, P., Sohr, B., Löffler, A., Kronister, S., Fernandez Del Castillo, A., Goldeck, M., Dzijak, R., Rahm, M., Vrabel, M., Svatunek, D., Carlson, J. C. T., & Mikula, H. (2025). Cover Picture: Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes (Angew. Chem. Int. Ed. 5/2025) (Vols. 64, 5) [Still Image]. https://doi.org/10.1002/anie.202423133 ( reposiTUm)

Spezialbeiträge

Mikula, H. (2022, December 6). Die Nobelpreise 2022: Chemie [Interview]. Radio Ö1. ( reposiTUm)
Mikula, H. (2022, December 15). Portrait Hannes Mikula: Keine Minute ist so produktiv wie die letzte [Interview]. Österreichische Ärztezeitung. ( reposiTUm)
Mikula, H. (2022, November 9). Mit Click Chemie gegen den Krebs [Interview]. radiofabrik. ( reposiTUm)

Hochschulschriften

Mikula, H. (2013). Advanced synthesis of conjugated metabolites and structural investigations of Fusarium and Alternaria Mycotoxins [Dissertation, Technische Universität Wien]. reposiTUm. http://hdl.handle.net/20.500.12708/160016 ( reposiTUm)
Mikula, H. (2008). Regioselektive O-Glucuronidierung untersucht am Beispiel des Fusarium Mykotoxins Zearalenon [Master Thesis, Technische Universität Wien]. reposiTUm. https://resolver.obvsg.at/urn:nbn:at:at-ubtuw:1-28276 ( reposiTUm)