Wissenschaftliche Artikel

Feiner, I. V. J., Svatunek, D., Pressler, M., Demuth, T., Guarrochena, X., H., S., Johannes, Susanne, D., Pichler, C., Denk, C., & Mindt, T. L. (2025). Towards DFO*12—Preliminary Results of a New Chelator for the Complexation of Actinium-225. Pharmaceutics, 17(3), Article 320. https://doi.org/10.3390/pharmaceutics17030320 ( reposiTUm)
Happl, B., Balber, T., Heffeter, P., Denk, C., Welch, J. M., Köster, U., Alliot, C., Bonraisin, A.-C., Brandt, M., Haddad, F., Sterba, J. H., Kandioller, W., Mitterhauser, M., Hacker, M., Keppler, B. K., & Mindt, T. L. (2024). Synthesis and preclinical evaluation of BOLD-100 radiolabeled with ruthenium-97 and ruthenium-103. Dalton Transactions, 53(13), 6031–6040. https://doi.org/10.1039/d4dt00118d ( reposiTUm)
Wilkovitsch, M., Svatunek, D., Mikula, H., & Denk, C. (2023). Post-radiolabeling thioether oxidation to enhance the bioorthogonal reactivity of 18F-tetrazines. MONATSHEFTE FUR CHEMIE, 154(12), 1441–1457. https://doi.org/10.1007/s00706-023-03140-w ( reposiTUm)
Steen, E. J. L., Jørgensen, J. T., Denk, C., Battisti, U. M., Nørregaard, K., Edem, P. E., Bratteby, K., Shalgunov, V., Wilkovitsch, M., Svatunek, D., Poulie, C., Hvass, L., Simón, M., Wanek, T., Rossin, R., Robillard, M., Kristensen, J., Mikula, H., Kjaer, A., & Herth, M. (2021). Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry. ACS Pharmacology & Translational Science, 4(2), 824–833. https://doi.org/10.1021/acsptsci.1c00007 ( reposiTUm)
Svatunek, D., Eilenberger, G., Denk, C., Lumpi, D., Hametner, C., Allmaier, G., & Mikula, H. (2020). Live Monitoring of Strain‐Promoted Azide Alkyne Cycloadditions in Complex Reaction Environments by Inline ATR‐IR Spectroscopy. Chemistry - A European Journal, 26(44), 9851–9854. https://doi.org/10.1002/chem.201905478 ( reposiTUm)
Steen, E. J., Shalgunov, V., Denk, C., Mikula, H., Kjaer, A., Kristensen, J., & Herth, M. (2019). Convenient Entry to 18F-labeled Amines Through the Staudinger Reduction. European Journal of Organic Chemistry, 2019(8), 1722–1725. http://hdl.handle.net/20.500.12708/142445 ( reposiTUm)
Rosecker, V., Denk, C., Maurer, M., Wilkovitsch, M., Mairinger, S., Wanek, T., & Mikula, H. (2019). Cross‐Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications. ChemBioChem, 20(12), 1530–1535. https://doi.org/10.1002/cbic.201900042 ( reposiTUm)
Denk, C., Wilkovitsch, M., Aneheim, E., Herth, M. M., Jensen, H., Lindegren, S., & Mikula, H. (2019). Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking. ChemPlusChem, 84(7), 774–774. https://doi.org/10.1002/cplu.201900250 ( reposiTUm)
Svatunek, D., Denk, C., & Mikula, H. (2018). A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines. Monatshefte Für Chemie - Chemical Monthly. https://doi.org/10.1007/s00706-017-2110-x ( reposiTUm)
Kronister, S., Svatunek, D., Denk, C., & Mikula, H. (2018). Acylation-Mediated “Kinetic Turn-On” of 3-Amino-1,2,4,5-tetrazines. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 29(10), 1297–1302. https://doi.org/10.1055/s-0036-1591764 ( reposiTUm)
Denk, C., Wilkovitsch, M., Skrinjar, P., Svatunek, D., Mairinger, S., Kuntner, C., Filip, T., Fröhlich, J., Wanek, T., & Mikula, H. (2017). [18F]Fluoroalkyl azides for rapid radiolabeling and (Re)investigation of their potential towards in vivo click chemistry. Organic and Biomolecular Chemistry, 15(28), 5976–5982. https://doi.org/10.1039/c7ob00880e ( reposiTUm)
Svatunek, D., Denk, C., Rosecker, V., Sohr, B., Hametner, C., Allmaier, G., Fröhlich, J., & Mikula, H. (2016). Efficient low-cost preparation of trans-cyclooctenes using a simplified flow setup for photoisomerization. Monatshefte Für Chemie - Chemical Monthly. https://doi.org/10.1007/s00706-016-1668-z ( reposiTUm)
Denk, C., Svatunek, D., Mairinger, S., Stanek, J., Filip, T., Matscheko, D., Kuntner, C., Wanek, T., & Mikula, H. (2016). Design, Synthesis, and Evaluation of a Low-Molecular-Weight 11C-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry. Bioconjugate Chemistry, 27(7), 1707–1712. https://doi.org/10.1021/acs.bioconjchem.6b00234 ( reposiTUm)
Wanek, T., Kreis, K., Križková, P., Schweifer, A., Denk, C., Stanek, J., Mairinger, S., Filip, T., Sauberer, M., Edelhofer, P., Traxl, A., Muchitsch, V. E., Mereiter, K., Hammerschmidt, F., Cass, C. E., Damaraju, V. L., Langer, O., & Kuntner, C. (2016). Synthesis and preclinical characterization of 1-(6’-deoxy-6’-[18F]fluoro-β-D-allofuranosyl)-2-nitroimidazole (β-6’-[18F]FAZAL) as a positron emission tomography radiotracer to assess tumor hypoxia. Bioorganic and Medicinal Chemistry, 24(21), 5326–5339. https://doi.org/10.1016/j.bmc.2016.08.053 ( reposiTUm)
Denk, C., Svatunek, D., Wanek, T., Mairinger, S., Stanek, J., Filip, T., Fröhlich, J., Mikula, H., & Kuntner, C. (2016). Bioorthogonal Tools for PET Imaging: Development of Radiolabeled 1,2,4,5-Tetrazines. EJNMMI Research, 6(Suppl 1), 8–9. http://hdl.handle.net/20.500.12708/49563 ( reposiTUm)
Denk, C., Svatunek, D., Sohr, B., Mikula, H., Fröhlich, J., Wanek, T., Kuntner, C., & Filip, T. (2016). Investigation of Small [18F]-Fluoroalkylazides for Rapid Radiolabeling and In Vivo Click Chemistry. EJNMMI Research, 6(Suppl 1), 9–9. http://hdl.handle.net/20.500.12708/49564 ( reposiTUm)
Svatunek, D., Denk, C., Wilkovitsch, M., Fröhlich, J., Wanek, T., Filip, T., Kuntner, C., & Mikula, H. (2016). 18F labeled azidoglucose derivatives as “click” agents for pretargeted PET imaging. EJNMMI Research, 6(Suppl 1), 8–8. http://hdl.handle.net/20.500.12708/49707 ( reposiTUm)
Denk, C., Svatunek, D., Filip, T., Wanek, T., Lumpi, D., Fröhlich, J., Kuntner, C., & Mikula, H. (2014). Development of a 18F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 9655–9659. http://hdl.handle.net/20.500.12708/158024 ( reposiTUm)

Beiträge in Tagungsbänden

Denk, C. (2019). Bioorthogonal Ligations In Radiopharmaceutical Sciences. In 18. Österreichische Chemietage (p. 1). http://hdl.handle.net/20.500.12708/50725 ( reposiTUm)
Kronister, S., Denk, C., Svatunek, D., & Mikula, H. (2017). Kinetics Of Amino And Amido Tetrazines In Bioorthogonal Ligations. In 17th Blue Danube Symposium on Heterocyclic Chemistry (p. 89). http://hdl.handle.net/20.500.12708/50109 ( reposiTUm)
Kuba, W., Wanek, T., Denk, C., & Mikula, H. (2017). Bioorthogonal Click-to-Release Chemistry for Rapid Radiolabeling. In 17. Österreichische Chemietage 2017 (p. 1). http://hdl.handle.net/20.500.12708/50095 ( reposiTUm)
Denk, C., Wilkovitsch, M., Wanek, T., Kuntner, C., Svatunek, D., & Mikula, H. (2017). Radiolabeled 1,2,4,5-Tetrazines As Bioorthogonal Imaging Tools. In 10th Joint Meeting on Medicinal Chemistry - Book of Abstracts (p. 103). http://hdl.handle.net/20.500.12708/50110 ( reposiTUm)
Sohr, B., Denk, C., Wanek, T., & Mikula, H. (2017). Development Of Bioorthogonal 2-Nitroimidazole Based Hypoxia Sensitive Probes. In 10th Joint Meeting on Medicinal Chemistry - Book of Abstracts (p. 215). http://hdl.handle.net/20.500.12708/50075 ( reposiTUm)
Houszka, N., Svatunek, D., Denk, C., Hametner, C., Fröhlich, J., Allmaier, G., & Mikula, H. (2016). Reactivity Of Secondary And Tertiary Azides In The Strain-Promoted Alkyne Azide Cycloaddition. In ECHC 2016 - XXVII European Colloquium on Heterocyclic Chemistry (p. 205). http://hdl.handle.net/20.500.12708/49737 ( reposiTUm)
Denk, C., Eilenberger, G., Linert, W., Lumpi, D., Mikula, H., Hametner, C., & Fröhlich, J. (2013). Kinetics of Tetrazine Ligations: From Organic to Biological Media. In Abstracts Book (p. 61). http://hdl.handle.net/20.500.12708/48203 ( reposiTUm)
Eilenberger, G., Lumpi, D., Denk, C., Mikula, H., Hametner, C., & Fröhlich, J. (2013). ATR-IR Inline Monitoring of Strain Promoted Alkyne-Azide Cycloadditions in Biological Media. In Abstracts Book (p. 135). http://hdl.handle.net/20.500.12708/48204 ( reposiTUm)

Präsentationen

Kratena, N., Demuth, T., Denk, C., Mairinger, S., Langer, O., & Mikula, H. (2024, July 31). Synthesis of a modified ACE2-inhibitor for 18F, 11C and 124I isotopic radiolabelling and PET tracer development [Poster Presentation]. ACS Publications Symposium: Catalysis for Organic Synthesis, Vienna, Austria. http://hdl.handle.net/20.500.12708/208509 ( reposiTUm)
Rosecker, V., Pressler, M., Denk, C., & Stasiuk, G. (2024, August 27). Production and purification of Au-199 from natural platinum(0) in a research reactor [Conference Presentation]. 19th International Workshop on Targetry and Target Chemistry (WTTC19), Heidelberg, Germany. http://hdl.handle.net/20.500.12708/206463 ( reposiTUm)
Kratena, N., Demuth, T., Denk, C., Mairinger, S., Langer, O., & Mikula, H. (2024, July 3). Synthesis of a modified ACE2-inhibitor for 18F, 11C and 124I isotopic radiolabelling and PET tracer development [Poster Presentation]. 18th Belgian Organic Synthesis Symposium (BOSS XVIII ), Liege, Belgium. http://hdl.handle.net/20.500.12708/208507 ( reposiTUm)
Pressler, M., Denk, C., Scheibelreiter, V., Kuba, W., & Mikula, H. (2022, April 8). PREPARATION OF AN AC-225 GENERATOR FROM AN OLD U-232/233 SAMPLE AND SUCCESSFUL AC-225 RADIOLABELING OF A NOVEL DOTA 1,2,4,5-TETRAZINE DERIVATIVE [Conference Presentation]. Twelfth International Conference on Methods and Applications of Radioanalytical Chemistry, KAILUA-KONA, HAWAII, United States of America (the). ( reposiTUm)
Rosecker, V., Denk, C., Maurer, M., & Mikula, H. (2018). Development of a Hybrid-Theranostic-System. Marc Xi (2018), Hawaii, United States of America (the). http://hdl.handle.net/20.500.12708/134522 ( reposiTUm)
Denk, C. (2015). Radiolabeled 1,2,4,5-Tetrazines: Tools for Bioorthogonal PET Imaging. 2nd Göttingen SPIRIT “Summer” School “Multimodal Imaging from high resolution in vitro towards in vivo imaging,” Göttingen, Germany. http://hdl.handle.net/20.500.12708/99846 ( reposiTUm)
Denk, C., Duffy, M., Hermann, S., Faust, A., Svatunek, D., Fröhlich, J., Schäfers, M., & Mikula, H. (2015). Radioiodinated 1,2,4,5-Tetrazine (Radio)Synthesis and in vivo Evaluation for Therapeutic Pretargeting. World Molecular Imaging Congress 2015, Honolulu, United States of America (the). http://hdl.handle.net/20.500.12708/99845 ( reposiTUm)
Denk, C., Mairinger, S., Stanek, J., Wanek, T., Filip, T., Svatunek, D., Fröhlich, J., Kuntner, C., & Mikula, H. (2015). Development and Evaluation of a small [11C]-Tetrazine as bioorthogonal PET Probe. World Molecular Imaging Congress 2015, Honolulu, United States of America (the). http://hdl.handle.net/20.500.12708/99844 ( reposiTUm)
Denk, C., Svatunek, D., Filip, T., Wanek, T., Lumpi, D., Fröhlich, J., Kuntner, C., & Mikula, H. (2014). Development and Evaluation of Radiolabeled 1,2,4,5-Tetrazines: Tools for Pretargeted PET Imaging. World Molecular Imaging Congress 2014, Seoul, Korea (the Republic of). http://hdl.handle.net/20.500.12708/99853 ( reposiTUm)

Hochschulschriften

Denk, C. (2016). Development of radiolabeled bioorthogonal in vivo click agents for diagnostic pretargeting [Dissertation, Technische Universität Wien]. reposiTUm. https://doi.org/10.34726/hss.2016.37961 ( reposiTUm)