Wissenschaftliche Artikel

Klausser, R., Veiter, L., Kopp-Hausjell, J., Hammerschmidt, N., Frierss, T., Gisperg, F., Elshazly, M., Prada, E., Martinetz, M., Voigtmann, M., & Spadiut, O. (2026). Increased purity and refolding yield of bacterial inclusion bodies by recursive high pressure homogenization. Journal of Biotechnology, 409, 183–194. https://doi.org/10.1016/j.jbiotec.2025.11.004 ( reposiTUm)
Hochedlinger, S., Klausser, R., Kopp, J., Jakubek, S., Kozek, M., & Spadiut, O. (2026). A distributed-parameter observer for estimating the distribution of concentrations in a tubular protein refolding reactor. Chemical Engineering Science, 320, Article 122442. https://doi.org/10.1016/j.ces.2025.122442 ( reposiTUm)
Gisperg, F., Klausser, R., Elshazly, M., Kopp, J., Přáda Brichtová, E., & Spadiut, O. (2025). Bayesian Optimization in Bioprocess Engineering—Where Do We Stand Today? Biotechnology and Bioengineering, 122(6), 1313–1325. https://doi.org/10.1002/bit.28960 ( reposiTUm)
Elshazly, M., Leeb, B., Prada Brichtova, E., Gisperg, F., Klausser, R., Vijayakumar, S., Lendl, B., Voigtmann, M., Berkemeyer, M., Spadiut, O., & Kopp, J. (2025). Investigating the influence of process parameters on the properties and refolding yield of single-chain variable fragment inclusion bodies. Journal of Biotechnology, 405, 182–190. https://doi.org/10.1016/j.jbiotec.2025.05.014 ( reposiTUm)
Igwe, C. L., Gisperg, F., Kierein, M., Brichtová, E. P., Spadiut, O., & Müller, D. F. (2024). Mechanistic soft-sensor design for protein refolding processes based on intrinsic fluorescence measurements. COMPUTERS & CHEMICAL ENGINEERING, 187, 1–11. https://doi.org/10.1016/j.compchemeng.2024.108734 ( reposiTUm)
Szabadi, A., Klausser, R., Spadiut, O., & Schröder, C. (2024). Inclusion Bodies in Ionic Liquids. Liquids, 4(1), 1–31. https://doi.org/10.3390/liquids4010001 ( reposiTUm)
Klausser, R., Kopp, J., Prada, E., Gisperg, F., Elshazly, M., & Spadiut, O. (2023). State-of-the-art and novel approaches to mild solubilization of inclusion bodies. Frontiers in Bioengineering and Biotechnology, 11, 1249196. https://doi.org/10.3389/fbioe.2023.1249196 ( reposiTUm)

Präsentationen

Prada, E., Igwe, C. L., Müller, D. F., Gisperg, F., Pauk, J. N., Kierein, M., Elshazly, M., Klausser, R., Kopp, J., & Spadiut, O. (2024, April 10). Online monitoring of protein refolding in inclusion body processing using intrinsic fluorescence [Conference Presentation]. 8th BioProScale Symposium, Berlin, Germany. http://hdl.handle.net/20.500.12708/208484 ( reposiTUm)
Igwe, C. L., Gisperg, F., Kierein, M., Přáda Brichtová, E., Spadiut, O., & Müller, D. F. (2024, April 9). Mechanistic soft-sensor design for protein refolding processes based on intrinsic fluorescence measurements [Poster Presentation]. 8th BioProScale Symposium 2024, Berlin, Germany. http://hdl.handle.net/20.500.12708/208311 ( reposiTUm)
Klausser, R. (2023, November 14). Analysis of cell lysis efficiency and inclusion body size distribution via centrifugal sedimentation [Poster Presentation]. PEGS Europe: Protein and Antibody Engineering Summit 2023, Lisbon, Portugal. ( reposiTUm)