<div class="csl-bib-body">
<div class="csl-entry">Qin, X.-H., Chen, J., Labuda, K., Hruschka, V., Liska, R., Redl, H., & Slezak, P. (2022). <i>Molecularly Engineered PEG-TRAP Conjugates for Platelet Activation and Accelerated Hemostasis</i>. https://doi.org/10.34726/4362</div>
</div>
-
dc.identifier.uri
http://hdl.handle.net/20.500.12708/177701
-
dc.identifier.uri
https://doi.org/10.34726/4362
-
dc.description.abstract
Synthetic peptide conjugates that can molecularly target and activate blood platelets are designed for hemostasis applications. An engineered thrombin receptor-activating peptide (TRAP-Cys, SFLLRNPNC) is covalently attached to cell-compatible 8-arm poly (ethylene glycol) maleimides via Michael addition. It is proved that the ability of TRAP to activate platelets is retained in the conjugated form by means of thromboelastometry, platelet aggregation assay and flow cytometry. A 0.5 % PEG-TRAP solution can efficiently activate platelets and shorten the clotting time to ~45 %.
en
dc.language.iso
en
-
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
-
dc.subject
PEG
en
dc.subject
hemostasis
en
dc.subject
Polymer-peptide conjugates
en
dc.subject
platelet activation
en
dc.subject
thrombin receptor-activating peptide (TRAP)
en
dc.subject
hemostasis
en
dc.subject
Blood coagulation
en
dc.title
Molecularly Engineered PEG-TRAP Conjugates for Platelet Activation and Accelerated Hemostasis
en
dc.type
Report
en
dc.type
Bericht
de
dc.rights.license
Creative Commons Namensnennung 4.0 International
de
dc.rights.license
Creative Commons Attribution 4.0 International
en
dc.identifier.doi
10.34726/4362
-
dc.contributor.affiliation
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austria
-
dc.contributor.affiliation
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austria
-
dc.contributor.affiliation
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austria
-
dc.contributor.affiliation
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austria
-
dc.contributor.affiliation
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austria
