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<div class="csl-entry">Anselmetti, D. (2010). <i>Biophysics at the Nanoscale: Molecular Forces, Dynamics and Biomimetics</i>. Seminar Institut für Allgemeine Physik (IAP), TU Wien, Austria. http://hdl.handle.net/20.500.12708/128009</div>
The detection and quantitative analysis of single (bio)molecules, smallest analyte quantities and the hunt for low abundant proteins at the single cell level, require new sensitive and efficient techniques. Over the last 15 years, novel biophysical measurement concepts have been conceived with an offspring of ultrasensitive methods that allow to image, measure, analyze, steer, and manipulate individual (bio)molecules and cells by atomic force microscopy / force spectroscopy, optical tweezers, micro- and nanofluidics and single molecule optical microscopy beyond the diffraction limit.
Beyond more fundamental investigations of complex biomolecular reactions, where a quantitative and more detailed insight into the physical mechanism of specific interaction, binding kinetics, and (non-linear) dynamics at the single molecule or single cell level can be achieved, especially, novel concepts with (switchable and bistable) supramolecular host-guest molecules and artificial nanopores will allow fascinating applications and in the fields of biomimetics, synthetic biology and molecular biomedicine.
Biophysics at the Nanoscale: Molecular Forces, Dynamics and Biomimetics