<div class="csl-bib-body">
<div class="csl-entry">Templ, J., & Schnürch, M. (2022). Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents. <i>Journal of Organic Chemistry</i>, <i>87</i>(6), 4305–4315. https://doi.org/10.1021/acs.joc.1c03158</div>
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dc.identifier.issn
0022-3263
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/136249
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dc.description.abstract
We describe the use of phenyl trimethylammonium iodide (PhMe3NI) as an alternative methylating agent for introducing a CH3group in α-position to a carbonyl group. Compared to conventional methylating agents, quaternary ammonium salts have the advantages of being nonvolatile, noncancerogenic, and easy-to-handle solids. This regioselective method is characterized by ease of operational setup, use of anisole as green solvent, and yields up to 85%.
en
dc.description.sponsorship
Fonds zur Förderung der wissenschaftlichen Forschung (FWF)
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dc.language.iso
en
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dc.publisher
American Chemical Society (ACS)
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dc.relation.ispartof
Journal of Organic Chemistry
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.subject
Methylation
en
dc.subject
ammonium salt
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dc.subject
ketone
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dc.title
Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents
