<div class="csl-bib-body">
<div class="csl-entry">Kratz, S. R. A., Bachmann, B., Spitz, S., Höll, G., Eilenberger, C., Goeritz, H., Ertl, P., & Rothbauer, M. (2020). A compression transmission device for the evaluation of bonding strength of biocompatible microfluidic and biochip materials and systems. <i>Scientific Reports</i>, <i>10</i>, Article 1400. https://doi.org/10.1038/s41598-020-58373-0</div>
</div>
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dc.identifier.issn
2045-2322
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/140362
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dc.description.abstract
Bonding of a variety of inorganic and organic polymers as multi-layered structures is one of the main challenges for biochip production even to date, since the chemical nature of these materials often does not allow easy and straight forward bonding and proper sealing. After selection of an appropriate method to bond the chosen materials to form a complex biochip, function and stability of bonding either requires qualitative burst tests or expensive mechanical multi-test stations, that often do not have the right adaptors to clamp biochip slides without destruction. Therefore, we have developed a simple and inexpensive bonding test based on 3D printed transmission elements that translate compressive forces via manual compression, hand press or hydraulic press compression into shear and tensile force. Mechanical stress simulations showed that design of the bonding geometry and size must be considered for bonding tests since the stress distribution thus bonding strength heavily varies with size but also with geometry. We demonstrate the broad applicability of our 3D printed bonding test system by testing the most frequent bonding strategies in combination with the respective most frequently used biochip material in a force-to-failure study. All evaluated materials are biocompatible and used in cell-based biochip devices. This study is evaluating state-of-the-art bonding approaches used for sealing of microfluidic biochips including adhesive bonding, plasma bonding, solvent bonding as well as bonding mediated by amino-silane monolayers or even functional thiol-ene epoxy biochip materials that obviate intermediate adhesive layers.
en
dc.language.iso
en
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dc.relation.ispartof
Scientific Reports
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dc.subject
Multidisciplinary
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dc.title
A compression transmission device for the evaluation of bonding strength of biocompatible microfluidic and biochip materials and systems
en
dc.type
Artikel
de
dc.type
Article
en
dc.type.category
Original Research Article
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tuw.container.volume
10
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tuw.journal.peerreviewed
true
-
tuw.peerreviewed
true
-
tuw.researchTopic.id
X1
-
tuw.researchTopic.name
außerhalb der gesamtuniversitären Forschungsschwerpunkte
-
tuw.researchTopic.value
100
-
dcterms.isPartOf.title
Scientific Reports
-
tuw.publication.orgunit
E163-03-1 - Forschungsgruppe Cell Chip
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tuw.publication.orgunit
E164-02-3 - Forschungsgruppe Cell Chip
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tuw.publisher.doi
10.1038/s41598-020-58373-0
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dc.identifier.articleid
1400
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dc.identifier.eissn
2045-2322
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dc.description.numberOfPages
13
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wb.sci
true
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wb.sciencebranch
Chemie
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wb.sciencebranch
Werkstofftechnik
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wb.sciencebranch.oefos
1040
-
wb.sciencebranch.oefos
2050
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wb.facultyfocus
Bioscience Technology
de
wb.facultyfocus
Bioscience Technology
en
wb.facultyfocus.faculty
E150
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item.openairetype
Artikel
-
item.openairetype
Article
-
item.cerifentitytype
Publications
-
item.cerifentitytype
Publications
-
item.languageiso639-1
en
-
item.grantfulltext
none
-
item.openairecristype
http://purl.org/coar/resource_type/c_18cf
-
item.openairecristype
http://purl.org/coar/resource_type/c_18cf
-
item.fulltext
no Fulltext
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crisitem.author.dept
E163-03-1 - Forschungsgruppe Cell Chip
-
crisitem.author.dept
E163-03-1 - Forschungsgruppe Cell Chip
-
crisitem.author.dept
E163-03-1 - Forschungsgruppe Cell Chip
-
crisitem.author.dept
E362 - Institut für Festkörperelektronik
-
crisitem.author.dept
E610 - Vizerektorat Forschung und Innovation
-
crisitem.author.dept
E163-03-1 - Forschungsgruppe Cell Chip
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crisitem.author.orcid
0000-0002-7625-2445
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
-
crisitem.author.parentorg
E350 - Fakultät für Elektrotechnik und Informationstechnik
-
crisitem.author.parentorg
E000 - Technische Universität Wien
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie