<div class="csl-bib-body">
<div class="csl-entry">Riedelberger, M., Penninger, P., Tscherner, M., Hadriga, B., Brunnhofer, C., Jenull, S., Stoiber, A., Bourgeois, C., Petryshyn, A., Glaser, W., Limbeck, A., Lynes, M., Schabbauer, G., Weiss, G., & Kuchler, K. (2020). Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion. <i>IScience</i>, <i>23</i>, 1–23. https://doi.org/10.1016/j.isci.2020.101121</div>
</div>
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dc.identifier.issn
2589-0042
-
dc.identifier.uri
http://hdl.handle.net/20.500.12708/141469
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dc.description.abstract
Host and fungal pathogens compete for metal ion acquisition during infectious processes, but molecular mechanisms remain largely unknown. Here, we show that type I interferons (IFNs-I) dysregulate zinc homeostasis in macrophages, which employ metallothionein-mediated zinc intoxication of pathogens as fungicidal response. However, Candida glabrata can escape immune surveillance by sequestering zinc into vacuoles. Interestingly, zinc-loading is inhibited by IFNs- I, because a Janus kinase 1 (JAK1)-dependent suppression of zinc homeostasis affects zinc distribution in macrophages as well as generation of reactive oxygen species (ROS). In addition, systemic fungal infections elicit IFN-I responses that suppress splenic zinc homeostasis, thereby altering macrophage zinc pools that otherwise exert fungicidal actions. Thus, IFN-I signaling inadvertently increases fungal fitness both in vitro and in vivo during fungal infections. Our data reveal
an as yet unrecognized role for zinc intoxication in antifungal immunity and suggest that interfering with host zinc homeostasis may offer therapeutic options to treat invasive fungal infections.
en
dc.language.iso
en
-
dc.relation.ispartof
iScience
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dc.title
Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion
en
dc.type
Artikel
de
dc.type
Article
en
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Max Perutz Labs, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
University of Connecticut
-
dc.contributor.affiliation
Medical University of Vienna, Austria
-
dc.contributor.affiliation
Innsbruck Medical University, Austria
-
dc.contributor.affiliation
Medical University of Vienna, Austria
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dc.description.startpage
1
-
dc.description.endpage
23
-
dc.type.category
Original Research Article
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tuw.container.volume
23
-
tuw.journal.peerreviewed
true
-
tuw.peerreviewed
true
-
wb.publication.intCoWork
International Co-publication
-
tuw.researchTopic.id
M6
-
tuw.researchTopic.name
Biological and Bioactive Materials
-
tuw.researchTopic.value
100
-
dcterms.isPartOf.title
iScience
-
tuw.publication.orgunit
E164-01-2 - Forschungsgruppe Oberflächen-, Spurenanalytik und Chemometrie
-
tuw.publisher.doi
10.1016/j.isci.2020.101121
-
dc.identifier.eissn
2589-0042
-
dc.description.numberOfPages
23
-
tuw.author.orcid
0000-0001-5492-5453
-
tuw.author.orcid
0000-0001-7487-2918
-
tuw.author.orcid
0000-0002-8768-4411
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tuw.author.orcid
0000-0002-7478-1386
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tuw.author.orcid
0000-0002-5993-8779
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tuw.author.orcid
0000-0001-5042-2445
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tuw.author.orcid
0000-0003-0085-5394
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tuw.author.orcid
0000-0002-7490-8009
-
tuw.author.orcid
0000-0003-2719-5955
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wb.sci
true
-
wb.sciencebranch
Chemie
-
wb.sciencebranch.oefos
1040
-
wb.facultyfocus
Bioscience Technology
de
wb.facultyfocus
Bioscience Technology
en
wb.facultyfocus.faculty
E150
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item.openairecristype
http://purl.org/coar/resource_type/c_2df8fbb1
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item.grantfulltext
none
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item.languageiso639-1
en
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item.cerifentitytype
Publications
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item.fulltext
no Fulltext
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item.openairetype
research article
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crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
E163 - Institut für Angewandte Synthesechemie
-
crisitem.author.dept
Max Perutz Labs
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
E164-01-2 - Forschungsgruppe Oberflächen-, Spurenanalytik und Chemometrie
-
crisitem.author.dept
University of Connecticut
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
Innsbruck Medical University
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.orcid
0000-0001-5492-5453
-
crisitem.author.orcid
0000-0001-7487-2918
-
crisitem.author.orcid
0000-0002-8768-4411
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crisitem.author.orcid
0000-0002-7478-1386
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crisitem.author.orcid
0000-0002-5993-8779
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crisitem.author.orcid
0000-0001-5042-2445
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crisitem.author.orcid
0000-0003-0085-5394
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crisitem.author.orcid
0000-0002-7490-8009
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crisitem.author.orcid
0000-0003-2719-5955
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crisitem.author.parentorg
E150 - Fakultät für Technische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie