<div class="csl-bib-body">
<div class="csl-entry">Riedelberger, M., Penninger, P., Tscherner, M., Seifert, M., Jenull, S., Brunnhofer, C., Scheidl, B., Tsymala, I., Bourgeois, C., Petryshyn, A., Glaser, W., Limbeck, A., Strobl, B., Weiss, G., & Kuchler, K. (2020). Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection. <i>Cell Host & Microbe</i>, <i>27</i>(3), 454-466.e8. https://doi.org/10.1016/j.chom.2020.01.023</div>
</div>
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dc.identifier.issn
1931-3128
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/141480
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dc.description.abstract
Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I pro-mote the dysregulation of iron homeostasis in mac-rophages during systemic infections with the intra-cellular pathogen Candida glabrata, leading to fungal survival and persistence. By engaging JAK1, IFNs-I disturb the balance of the transcriptional acti-vator NRF2 and repressor BACH1 to induce downre-gulation of the key iron exporter Fpn1 in macro-phages. This leads to enhanced iron accumulation in the phagolysosome and failure to restrict fungal access to iron pools. As a result, C. glabrata acquires iron via the Sit1/Ftr1 iron transporter system, facili-tating fungal intracellular replication and immune evasion. Thus, IFNs-I are central regulators of iron homeostasis, which can impact infection, and re-stricting iron bioavailability may offer therapeutic strategies to combat invasive fungal infections.
en
dc.language.iso
en
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dc.relation.ispartof
Cell Host & Microbe
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dc.subject
Microbiology
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dc.subject
Virology
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dc.subject
Parasitology
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dc.title
Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection
en
dc.type
Artikel
de
dc.type
Article
en
dc.contributor.affiliation
Medical University of Vienna
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dc.description.startpage
454
-
dc.description.endpage
466.e8
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dc.type.category
Original Research Article
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tuw.container.volume
27
-
tuw.container.issue
3
-
tuw.journal.peerreviewed
true
-
tuw.peerreviewed
true
-
tuw.researchTopic.id
M6
-
tuw.researchTopic.name
Biological and Bioactive Materials
-
tuw.researchTopic.value
100
-
dcterms.isPartOf.title
Cell Host & Microbe
-
tuw.publication.orgunit
E164-01-2 - Forschungsgruppe Oberflächen-, Spurenanalytik und Chemometrie
-
tuw.publisher.doi
10.1016/j.chom.2020.01.023
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dc.identifier.eissn
1934-6069
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dc.description.numberOfPages
13
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tuw.author.orcid
0000-0002-8515-5209
-
tuw.author.orcid
0000-0001-5042-2445
-
wb.sci
true
-
wb.sciencebranch
Chemie
-
wb.sciencebranch.oefos
1040
-
wb.facultyfocus
Bioscience Technology
de
wb.facultyfocus
Bioscience Technology
en
wb.facultyfocus.faculty
E150
-
item.cerifentitytype
Publications
-
item.cerifentitytype
Publications
-
item.fulltext
no Fulltext
-
item.grantfulltext
none
-
item.openairecristype
http://purl.org/coar/resource_type/c_18cf
-
item.openairecristype
http://purl.org/coar/resource_type/c_18cf
-
item.openairetype
Artikel
-
item.openairetype
Article
-
item.languageiso639-1
en
-
crisitem.author.dept
E163 - Institut für Angewandte Synthesechemie
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
E164-01-2 - Forschungsgruppe Oberflächen-, Spurenanalytik und Chemometrie
-
crisitem.author.dept
E402 - Dekanatszentrum Getreidemarkt
-
crisitem.author.orcid
0000-0002-8515-5209
-
crisitem.author.orcid
0000-0001-5042-2445
-
crisitem.author.parentorg
E150 - Fakultät für Technische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E300 - Fakultät für Maschinenwesen und Betriebswissenschaften