<div class="csl-bib-body">
<div class="csl-entry">Ghodrati, M., Maurer, A., Schlöglhofer, T., Khienwad, T., Zimpfer, D., Beitzke, D., Zonta, F., Moscato, F., Schima, H., & Aigner, P. (2020). The influence of left ventricular assist device inflow cannula position on thrombosis risk. <i>Artificial Organs</i>, <i>44</i>(9), 939–946. https://doi.org/10.1111/aor.13705</div>
</div>
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dc.identifier.issn
0160-564X
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/141772
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dc.description.abstract
The use of left ventricular assist devices (LVADs) as a treatment method for heart failure patients has been steadily increasing; however, pathological studies showed presence of thrombi around the HeartWare ventricular assist device inflow cannula (IC) in more than 95% of patients after device explantation. Flow fields around the IC might trigger thrombus formation and require further investigation. In this study flow dynamics parameters were evaluated for different patient geometries using computational fluid dynamics (CFD) simulations. Left ventricular (LV) models of two LVAD patients were obtained from CT scans. The LV volumes of Patient 1 (P1) and Patient 2 (P2) were 264 and 114 cm3 with an IC angle of 20° and 9° from the mitral-IC tip axis at the coronal plane. The IC insertion site at the apex was central for P1, whereas it was lateral for P2. Transient CFD simulations were performed over 9 cardiac cycles. The wedge area was defined from the cannula tip to the wall of the LV apex. Mean velocity magnitude and blood stagnation region (volume with mean velocity <5 mm/s) as well as the wall shear stress (WSS) at the IC surface were calculated. Cardiac support resulted in a flow mainly crossing the ventricle from the mitral valve to the LVAD cannula for P2, while the main inflow jet deviated toward the septal wall in P1. Lower WSS at the IC surface and consequently larger stagnation volumes were observed for P2 (P1: 0.17, P2: 0.77 cm3 ). Flow fields around an LVAD cannula can be influenced by many parameters such as LV size, IC angle, and implantation site. Careful consideration of influencing parameters is essential to get reliable evaluations of the apical flow field and its connection to apical thrombus formation. Higher blood washout and lower stagnation were observed for a central implantation of the IC at the apex.
en
dc.language.iso
en
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dc.publisher
WILEY
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dc.relation.ispartof
Artificial Organs
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dc.subject
General Medicine
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dc.subject
Biomedical Engineering
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dc.subject
Bioengineering
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dc.subject
Biomaterials
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dc.subject
Medicine (miscellaneous)
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dc.subject
apical washout
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dc.subject
intraventricular flow pattern
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dc.subject
left ventricle assist device
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dc.subject
thrombosis risk.
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dc.title
The influence of left ventricular assist device inflow cannula position on thrombosis risk
en
dc.type
Artikel
de
dc.type
Article
en
dc.description.startpage
939
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dc.description.endpage
946
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dc.type.category
Original Research Article
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tuw.container.volume
44
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tuw.container.issue
9
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tuw.journal.peerreviewed
true
-
tuw.peerreviewed
true
-
wb.publication.intCoWork
International Co-publication
-
tuw.researchTopic.id
C2
-
tuw.researchTopic.id
C1
-
tuw.researchTopic.name
Computational Fluid Dynamics
-
tuw.researchTopic.name
Computational Materials Science
-
tuw.researchTopic.value
50
-
tuw.researchTopic.value
50
-
dcterms.isPartOf.title
Artificial Organs
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tuw.publication.orgunit
E322-01 - Forschungsbereich Strömungsmechanik
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tuw.publisher.doi
10.1111/aor.13705
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dc.identifier.eissn
1525-1594
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dc.description.numberOfPages
8
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tuw.author.orcid
0000-0002-8475-3602
-
tuw.author.orcid
0000-0003-4354-4860
-
tuw.author.orcid
0000-0002-4045-634X
-
tuw.author.orcid
0000-0002-2185-4895
-
tuw.author.orcid
0000-0003-3179-3827
-
tuw.author.orcid
0000-0002-3849-315X
-
tuw.author.orcid
0000-0003-0279-6615
-
tuw.author.orcid
0000-0002-8003-7617
-
tuw.author.orcid
0000-0002-3212-2112
-
wb.sci
true
-
wb.sciencebranch
Physik, Astronomie
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wb.sciencebranch
Medizintechnik
-
wb.sciencebranch.oefos
1030
-
wb.sciencebranch.oefos
2060
-
wb.facultyfocus
Energie und Umwelttechnik
de
wb.facultyfocus
Energy and Environmental Technology
en
wb.facultyfocus.faculty
E300
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item.fulltext
no Fulltext
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item.openairecristype
http://purl.org/coar/resource_type/c_2df8fbb1
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item.cerifentitytype
Publications
-
item.openairetype
research article
-
item.grantfulltext
none
-
item.languageiso639-1
en
-
crisitem.author.dept
E322-01 - Forschungsbereich Strömungsmechanik
-
crisitem.author.parentorg
E322 - Institut für Strömungsmechanik und Wärmeübertragung