<div class="csl-bib-body">
<div class="csl-entry">Kratena, N., Marinic, B., & Donohoe, T. J. (2022). Recent advances in the dearomative functionalisation of heteroarenes. <i>Chemical Science</i>, <i>13</i>(48), 14213–14225. https://doi.org/10.1039/d2sc04638e</div>
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dc.identifier.issn
2041-6520
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/142221
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dc.description.abstract
Dearomatisation reactions of (hetero)arenes have been widely employed as efficient methods to obtain highly substituted saturated cyclic compounds for over a century. In recent years, research in this area has shifted towards effecting additional C-C bond formation during the overall dearomative process. Moving away from classical hydrogenation-based strategies a wide range of reagents were found to be capable of initiating dearomatisation through nucleophilic addition (typically a reduction) or photochemically induced radical addition. The dearomatisation process gives rise to reactive intermediates which can be intercepted in an intra- or intermolecular fashion to deliver products with significantly increased molecular complexity when compared to simple dearomatisation. In this Perspective recent examples and strategies for the dearomative functionalisation of heteroaromatic systems will be discussed.
en
dc.language.iso
en
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dc.publisher
ROYAL SOC CHEMISTRY
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dc.relation.ispartof
Chemical Science
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dc.subject
Dearomatisation Heterocyclen
en
dc.title
Recent advances in the dearomative functionalisation of heteroarenes