<div class="csl-bib-body">
<div class="csl-entry">Reisky, L., Préchoux, A., Zühlke, M.-K., Bäumgen, M., Robb, C. S., Gerlach, N., Roret, T., Stanetty, C., Larocque, R., Michel, G., Song, T., Markert, S., Unfried, F., Mihovilovic, M. D., Trautwein-Schult, A., Becher, D., Schweder, T., Bornscheuer, U. T., & Hehemann, J.-H. (2019). A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan. <i>Nature Chemical Biology</i>, <i>15</i>(8), 803–812. https://doi.org/10.1038/s41589-019-0311-9</div>
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dc.identifier.issn
1552-4450
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/143647
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dc.description.abstract
Marine seaweeds increasingly grow into extensive algal blooms, which are detrimental to coastal ecosystems, tourism and aquaculture. However, algal biomass is also emerging as a sustainable raw material for the bioeconomy. The potential exploitation of algae is hindered by our limited knowledge of the microbial pathways-and hence the distinct biochemical functions of the enzymes involved-that convert algal polysaccharides into oligo- and monosaccharides. Understanding these processes would be essential, however, for applications such as the fermentation of algal biomass into bioethanol or other value-added compounds. Here, we describe the metabolic pathway that enables the marine flavobacterium Formosa agariphila to degrade ulvan, the main cell wall polysaccharide of bloom-forming Ulva species. The pathway involves 12 biochemically characterized carbohydrate-active enzymes, including two polysaccharide lyases, three sulfatases and seven glycoside hydrolases that sequentially break down ulvan into fermentable monosaccharides. This way, the enzymes turn a previously unexploited renewable into a valuable and ecologically sustainable bioresource.
en
dc.language.iso
en
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dc.publisher
NATURE PORTFOLIO
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dc.relation.ispartof
Nature Chemical Biology
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dc.subject
Molecular Biology
en
dc.subject
Cell Biology
en
dc.title
A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan