<div class="csl-bib-body">
<div class="csl-entry">Part, F., Zaba, C., Bixner, O., Grünewald, T. A., Michor, H., Küpcü, S., Debreczeny, M., De Vito Francesco, E., Lassenberger, A., Schrittwieser, S., Hann, S., Lichtenegger, H., & Ehmoser, E.-K. (2018). Doping Method Determines Para- or Superparamagnetic Properties of Photostable and Surface-Modifiable Quantum Dots for Multimodal Bioimaging. <i>Chemistry of Materials</i>, <i>30</i>(13), 4233–4241. https://doi.org/10.1021/acs.chemmater.8b00431</div>
</div>
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dc.identifier.issn
0897-4756
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/145126
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dc.description.abstract
Semiconductor quantum dots (QDs) are widely used for optical applications and bioimaging. In comparison to organic dyes used for fluorescent labeling, QDs exhibit very high photostability and can be further surface modified. Equipping QDs with magnetic properties (mQDs) makes it possible to combine fluorescence and magnetic resonance imaging analyses. For this purpose, we have prepared water-dispersible and magnetic CdTe/ZnS mQDs, whereby ferrous ions are selectively incorporated in either their cores or their shells. This study aims at understanding the differences in optical, structural, and magnetic properties between these core- and shell-doped mQDs. Field-dependent isothermal magnetic susceptibility measurements show that shell-doped mQDs exhibit paramagnetic and their core-doped equivalents superparamagnetic behavior near room temperature. Shell doping results in about 1.7 times higher photoluminescence quantum yields and 1.4 times higher doping efficiency than core doping. X-ray diffraction patterns reveal that core doping leads to defects in the lattice and hence to a severe decrease in crystallinity, whereas shell doping has no significant impact on the crystal structure and consequently fewer disadvantages regarding the mQD's quantum yield. These selective doping approaches, particularly shell doping, allow for the tailored design of paramagnetic QDs having modifiable and biocompatible particle surfaces. The organic ligands--in this study N-acetyl-L-cysteine--sufficiently prevent leakage of toxic metal ions, as shown by cytotoxicity assays with HepG2 cells. Confocal laser scanning microscopy shows that mQDs are internalized by these cells and accumulated near their nuclei. This study shows that biocompatible, fluorescent, and paramagnetic QDs are promising photostable labels for multimodal bioimaging.
en
dc.language.iso
en
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dc.relation.ispartof
Chemistry of Materials
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dc.subject
General Chemistry
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dc.subject
Materials Chemistry
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dc.subject
General Chemical Engineering
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dc.title
Doping Method Determines Para- or Superparamagnetic Properties of Photostable and Surface-Modifiable Quantum Dots for Multimodal Bioimaging
en
dc.type
Artikel
de
dc.type
Article
en
dc.description.startpage
4233
-
dc.description.endpage
4241
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dc.type.category
Original Research Article
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tuw.container.volume
30
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tuw.container.issue
13
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tuw.journal.peerreviewed
true
-
tuw.peerreviewed
true
-
wb.publication.intCoWork
International Co-publication
-
tuw.researchTopic.id
M8
-
tuw.researchTopic.id
M7
-
tuw.researchTopic.name
Structure-Property Relationship
-
tuw.researchTopic.name
Special and Engineering Materials
-
tuw.researchTopic.value
50
-
tuw.researchTopic.value
50
-
dcterms.isPartOf.title
Chemistry of Materials
-
tuw.publication.orgunit
E138-03 - Forschungsbereich Functional and Magnetic Materials
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tuw.publisher.doi
10.1021/acs.chemmater.8b00431
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dc.identifier.eissn
1520-5002
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dc.description.numberOfPages
9
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tuw.author.orcid
0000-0003-1301-1502
-
tuw.author.orcid
0000-0001-5807-3331
-
tuw.author.orcid
0000-0001-5045-7293
-
tuw.author.orcid
0000-0002-6624-1419
-
tuw.author.orcid
0000-0001-9201-268X
-
wb.sci
true
-
wb.sciencebranch
Physik, Astronomie
-
wb.sciencebranch
Medizintechnik
-
wb.sciencebranch.oefos
1030
-
wb.sciencebranch.oefos
2060
-
wb.facultyfocus
Physikalische Technologie
de
wb.facultyfocus
Physical Technology
en
wb.facultyfocus.faculty
E130
-
item.languageiso639-1
en
-
item.openairecristype
http://purl.org/coar/resource_type/c_2df8fbb1
-
item.fulltext
no Fulltext
-
item.openairetype
research article
-
item.grantfulltext
none
-
item.cerifentitytype
Publications
-
crisitem.author.dept
E138-03 - Forschungsbereich Functional and Magnetic Materials
-
crisitem.author.dept
E308 - Institut für Werkstoffwissenschaft und Werkstofftechnologie
-
crisitem.author.orcid
0000-0003-1642-5946
-
crisitem.author.parentorg
E138 - Institut für Festkörperphysik
-
crisitem.author.parentorg
E300 - Fakultät für Maschinenwesen und Betriebswissenschaften