<div class="csl-bib-body">
<div class="csl-entry">Lunzer, M., Shi, L., Andriotis, O. G., Gruber, P., Markovic, M., Thurner, P. J., Ossipov, D., Liska, R., & Ovsianikov, A. (2018). A Modular Approach to Sensitized Two-Photon Patterning of Photodegradable Hydrogels. <i>Angewandte Chemie</i>, <i>130</i>(46), 15342–15347. https://doi.org/10.1002/ange.201808908</div>
</div>
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dc.identifier.issn
0044-8249
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/145446
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dc.description.abstract
Photodegradable hydrogels have emerged as useful platforms for research on cell function, tissue engineering, and cell delivery as their physical and chemical properties can be dynamically controlled by the use of light. The photo-induced degradation of such hydrogel systems is commonly based on the integration of photolabile o-nitrobenzyl derivatives to the hydrogel backbone, because such linkers can be cleaved by means of one- and two-photon absorption. Herein we describe a cytocompatible click-based hydrogel containing o-nitrobenzyl ester linkages between a hyaluronic acid backbone, which is photodegradable in the presence of cells. It is demonstrated for the first time that by using a cyclic benzylidene ketone-based small molecule as photosensitizer the efficiency of the two-photon degradation process can be improved significantly. Biocompatibility of both the improved two-photon micropatterning process as well as the hydrogel itself is confirmed by cell culture studies.
en
dc.language.iso
en
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dc.relation.ispartof
Angewandte Chemie
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dc.subject
General Medicine
en
dc.subject
photochemistry
en
dc.subject
hydrogels
en
dc.subject
biomaterials
en
dc.subject
hyaluronic acid
en
dc.subject
sensitizers
en
dc.title
A Modular Approach to Sensitized Two-Photon Patterning of Photodegradable Hydrogels
en
dc.type
Artikel
de
dc.type
Article
en
dc.description.startpage
15342
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dc.description.endpage
15347
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dc.type.category
Original Research Article
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tuw.container.volume
130
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tuw.container.issue
46
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tuw.journal.peerreviewed
true
-
tuw.peerreviewed
true
-
tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
-
dcterms.isPartOf.title
Angewandte Chemie
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tuw.publication.orgunit
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie
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tuw.publication.orgunit
E308-02 - Forschungsbereich Polymer- und Verbundwerkstoffe
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tuw.publication.orgunit
E317-02 - Forschungsbereich Biomechanik
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tuw.publisher.doi
10.1002/ange.201808908
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dc.date.onlinefirst
2018-09-06
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dc.identifier.eissn
1521-3757
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dc.description.numberOfPages
6
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tuw.author.orcid
0000-0002-8052-6517
-
tuw.author.orcid
0000-0002-2422-7280
-
tuw.author.orcid
0000-0003-4107-1510
-
tuw.author.orcid
0000-0001-7588-9041
-
tuw.author.orcid
0000-0003-2332-3665
-
tuw.author.orcid
0000-0001-7865-1936
-
tuw.author.orcid
0000-0001-5846-0198
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wb.sciencebranch
Maschinenbau
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wb.sciencebranch
Chemie
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wb.sciencebranch.oefos
2030
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wb.sciencebranch.oefos
1040
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wb.facultyfocus
Werkstoff- und Fertigungstechnologien
de
wb.facultyfocus
Material and Production Technology
en
wb.facultyfocus.faculty
E300
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item.languageiso639-1
en
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item.grantfulltext
none
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item.openairecristype
http://purl.org/coar/resource_type/c_2df8fbb1
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item.fulltext
no Fulltext
-
item.openairetype
research article
-
item.cerifentitytype
Publications
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crisitem.author.dept
E308-02-3 - Forschungsgruppe 3D Printing and Biofabrication
-
crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
E308 - Institut für Werkstoffwissenschaft und Werkstofftechnologie
-
crisitem.author.dept
E308-50-2 - Fachgruppe Technische Assistenz
-
crisitem.author.dept
E317 - Institut für Leichtbau und Struktur-Biomechanik