<div class="csl-bib-body">
<div class="csl-entry">Ching, K. Y., Andriotis, O. G., Li, S., Basnett, P., Su, B., Roy, I., Tare, R. S., Sengers, B. G., & Stolz, M. (2016). Nanofibrous poly(3-hydroxybutyrate)/poly(3-hydroxyoctanoate) scaffolds provide a functional microenvironment for cartilage repair. <i>Journal of Biomaterials Applications</i>, <i>31</i>(1), 77–91. https://doi.org/10.1177/0885328216639749</div>
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dc.identifier.issn
0885-3282
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/148835
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dc.description.abstract
Articular cartilage defects, when repaired ineffectively, often lead to further deterioration of the tissue, secondary osteoarthritis and, ultimately, joint replacement. Unfortunately, current surgical procedures are unable to restore normal cartilage function. Tissue engineering of cartilage provides promising strategies for the regeneration of damaged articular cartilage. As yet, there are still significant challenges that need to be overcome to match the long-term mechanical stability and durability of native cartilage. Using electrospinning of different blends of biodegradable poly(3-hydroxybutyrate)/poly(3-hydroxyoctanoate), we produced polymer scaffolds and optimised their structure, stiffness, degradation rates and biocompatibility. Scaffolds with a poly(3-hydroxybutyrate)/poly(3-hydroxyoctanoate) ratio of 1:0.25 exhibit randomly oriented fibres that closely mimic the collagen fibrillar meshwork of native cartilage and match the stiffness of native articular cartilage. Degradation of the scaffolds into products that could be easily removed from the body was indicated by changes in fibre structure, loss of molecular weight and a decrease in scaffold stiffness after one and four months. Histological and immunohistochemical analysis after three weeks of culture with human articular chondrocytes revealed a hyaline-like cartilage matrix. The ability to fine tune the ultrastructure and mechanical properties using different blends of poly(3-hydroxybutyrate)/poly(3-hydroxyoctanoate) allows to produce a cartilage repair kit for clinical use to reduce the risk of developing secondary osteoarthritis. We further suggest the development of a toolbox with tailor-made scaffolds for the repair of other tissues that require a 'guiding' structure to support the body's self-healing process.
en
dc.language.iso
en
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dc.publisher
SAGE PUBLICATIONS LTD
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dc.relation.ispartof
Journal of Biomaterials Applications
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dc.subject
Biomedical Engineering
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dc.subject
Biomaterials
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dc.title
Nanofibrous poly(3-hydroxybutyrate)/poly(3-hydroxyoctanoate) scaffolds provide a functional microenvironment for cartilage repair
en
dc.type
Artikel
de
dc.type
Article
en
dc.description.startpage
77
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dc.description.endpage
91
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dc.type.category
Original Research Article
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tuw.container.volume
31
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tuw.container.issue
1
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tuw.journal.peerreviewed
true
-
tuw.peerreviewed
true
-
tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
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dcterms.isPartOf.title
Journal of Biomaterials Applications
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tuw.publication.orgunit
E317-02 - Forschungsbereich Biomechanik
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tuw.publisher.doi
10.1177/0885328216639749
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dc.identifier.eissn
1530-8022
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dc.description.numberOfPages
15
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wb.sci
true
-
wb.sciencebranch
Medizintechnik
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wb.sciencebranch.oefos
2060
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wb.facultyfocus
Außerhalb der primären Forschungsgebiete der Fakultät
de
wb.facultyfocus
Outside the Faculty's primary research activities
en
item.languageiso639-1
en
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item.fulltext
no Fulltext
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item.openairetype
Artikel
-
item.openairetype
Article
-
item.cerifentitytype
Publications
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item.cerifentitytype
Publications
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item.openairecristype
http://purl.org/coar/resource_type/c_18cf
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item.openairecristype
http://purl.org/coar/resource_type/c_18cf
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item.grantfulltext
none
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crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
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crisitem.author.orcid
0000-0003-4107-1510
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crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik