DC FieldValueLanguage
dc.contributor.advisorFröhlich, Johannes-
dc.contributor.authorBogner, Paul-
dc.date.issued2020-
dc.date.submitted2020-08-
dc.identifier.urihttps://doi.org/10.34726/hss.2020.81530-
dc.descriptionArbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprüft-
dc.descriptionAbweichender Titel nach Übersetzung der Verfasserin/des Verfassers-
dc.description.abstractSince antibiotics are used to treat various bacterial infectious diseases there is a fight against bacterial resistance. As the concentration of the antibiotic in the blood is of great interest there is the need of measuring this concentration over time.This is called therapeutic drug monitoring (TDM). Some issues in the use of immunoassays favor LC-MS techniques to be used. For quantification in LC-MS an internal standard is needed where nowadays isotope labeled standards are used. The drawbacks of these are that they are expensive, not easy to synthesize and therefore have a limited availability. To cope with these issues the goal of the QUANTIS project as a cooperation betweenTU Vienna and ARCHIMEDlife® is to synthesize new internal standards via small modifications of the actual antibiotic.The modifications have to be so small that the chemical similarity needed to be a valid internal standard is still given. So, the idea was to tailor those quantification standards (TQS) to fit for their purpose. Various reactions such as homologation, conjugation and oxidation were considered to modify the antibiotics.In this thesis new potential TQS for antibiotics out of the class of β-lactams and aminoglycosides could be synthesized and one of them could also be validated so far.en
dc.format66 Seiten-
dc.languageEnglish-
dc.language.isoen-
dc.subjectantibioticsen
dc.subjecttherapeutic drug monitoringen
dc.subjectorganic synthesisen
dc.titleDevelopment of modified antibiotics as internal standards for therapeutic drug monitoringen
dc.typeThesisen
dc.typeHochschulschriftde
dc.identifier.doi10.34726/hss.2020.81530-
dc.publisher.placeWien-
tuw.thesisinformationTechnische Universität Wien-
dc.contributor.assistantMikula, Hannes-
tuw.publication.orgunitE163 - Institut für Angewandte Synthesechemie-
dc.type.qualificationlevelDiploma-
dc.identifier.libraryidAC15703931-
dc.description.numberOfPages66-
dc.thesistypeDiplomarbeitde
dc.thesistypeDiploma Thesisen
item.languageiso639-1en-
item.openairetypeThesis-
item.openairetypeHochschulschrift-
item.fulltextwith Fulltext-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
crisitem.author.deptE163 - Institut für Angewandte Synthesechemie-
crisitem.author.parentorgE150 - Fakultät für Technische Chemie-
Appears in Collections:Thesis

Files in this item:

Show simple item record

Page view(s)

16
checked on Apr 3, 2021

Download(s)

8
checked on Apr 3, 2021

Google ScholarTM

Check


Items in reposiTUm are protected by copyright, with all rights reserved, unless otherwise indicated.