<div class="csl-bib-body">
<div class="csl-entry">Hermann, D.-R., Ramer, G., & Lendl, B. (2022, May 13). <i>Fast investigation of chirality: Balanced detection and Quantum Cascade Lasers for improved Vibrational Circular Dichroism</i> [Conference Presentation]. Young Analytical Chemists Forum 2022, Tulln, Austria. http://hdl.handle.net/20.500.12708/152508</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/152508
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dc.description.abstract
Chirality is an integral part of chemistry, being present in small molecules and biological macromolecules like proteins.[1] It is readily accessible by chiroptical spectroscopy techniques, like Circular Dichroism (CD) and Vibrational Circular Dichroism (VCD). Unlike CD, which relies on the presence of specific chromophores in the analyte, VCD operates in the infrared region, which is rich in bands characteristic for most organic molecules. Unfortunately, besides the broad applicability, VCD is also characterised by weak signal amplitudes (10-5 – 10-6 compared to classical absorbance), which can also easily be distorted by birefringence artifacts originating in the optical components of the instrument.[2] High quality VCD spectra therefore are collected over long measurement times (up to several hours) to achieve reasonable signal-to-noise ratios.
Quantum Cascade lasers (QCLs) provide highly polarised light in the infrared region with a high spectral power density. These characteristics lend themselves well to VCD, possibly facilitating fast measurements while still obtaining low noise levels. Impressive results were already achieved for classical IR-spectroscopy, with QCL-based setups outperforming FT-IR spectrometer in terms of noise levels.[3] We aimed to achieve similar results also for VCD by augmenting a QCL based VCD setup by a balanced detection scheme. This allowed us to compensate for the noise present in QCLs, such as pulse to pulse fluctuations and thermal drifts.[3] We were able to acquire VCD spectra with measurement times below 10 minutes, while still outperforming FT-IR instruments in terms of noise levels by factors up to 6. Additionally, the properties of the used External Cavity -QCL (EC-QCL) would allow us to decrease the measurement time further, if a smaller spectral range is needed. We applied this improvement on an enantiomeric excess study of R/S-1,1′-Bi-2-naphthol in CHCl3 with measurement times below 5 minutes. We are confident that this scheme will enable improved applicability of VCD as a process analytical tool in chiral reactions and bioprocesses.
en
dc.description.sponsorship
FFG - Österr. Forschungsförderungs- gesellschaft mbH
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dc.language.iso
en
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dc.subject
Chirality
en
dc.subject
vibrational spectroscopy
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dc.subject
quantum cascade laser
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dc.title
Fast investigation of chirality: Balanced detection and Quantum Cascade Lasers for improved Vibrational Circular Dichroism
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.relation.grantno
868615
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dc.type.category
Conference Presentation
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tuw.project.title
Chemical Systems Engineering
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tuw.researchTopic.id
Q1
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tuw.researchTopic.name
Photonics
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tuw.researchTopic.value
100
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tuw.publication.orgunit
E164-02-1 - Forschungsgruppe Prozessanalytik
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tuw.author.orcid
0000-0001-8307-5435
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tuw.author.orcid
0000-0003-3838-5842
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tuw.event.name
Young Analytical Chemists Forum 2022
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tuw.event.startdate
12-05-2022
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tuw.event.enddate
13-05-2022
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Tulln
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tuw.event.country
AT
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tuw.event.presenter
Hermann, Daniel-Ralph
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wb.sciencebranch
Chemie
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wb.sciencebranch
Physik, Astronomie
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wb.sciencebranch.oefos
1040
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wb.sciencebranch.oefos
1030
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wb.sciencebranch.value
50
-
wb.sciencebranch.value
50
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item.openairetype
conference paper not in proceedings
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item.openairecristype
http://purl.org/coar/resource_type/c_18cp
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item.grantfulltext
none
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item.cerifentitytype
Publications
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item.fulltext
no Fulltext
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item.languageiso639-1
en
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crisitem.project.funder
FFG - Österr. Forschungsförderungs- gesellschaft mbH
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crisitem.project.grantno
868615
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crisitem.author.dept
E164-02-1 - Forschungsgruppe Prozessanalytik
-
crisitem.author.dept
E164-02-1 - Forschungsgruppe Prozessanalytik
-
crisitem.author.dept
E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
-
crisitem.author.orcid
0000-0003-2605-8203
-
crisitem.author.orcid
0000-0001-8307-5435
-
crisitem.author.orcid
0000-0003-3838-5842
-
crisitem.author.parentorg
E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
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crisitem.author.parentorg
E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
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crisitem.author.parentorg
E164 - Institut für Chemische Technologien und Analytik