Ramer, Georg

Vieira Dias Dos Santos, Ana Catarina

Yilmaz, Ufuk

Holub, Elisabeth

Zhang, Yide

Lendl, Bernhard

2023-02-15T16:31:30Z

2023-02-15T16:31:30Z

2022-06-23

<div class="csl-bib-body"> <div class="csl-entry">Ramer, G., Vieira Dias Dos Santos, A. C., Yilmaz, U., Holub, E., Zhang, Y., &#38; Lendl, B. (2022, June 23). <i>Photothermal spectroscopy for nanoscale chemical imaging</i> [Keynote Presentation]. ICPPP21, Bled, Slovenia. http://hdl.handle.net/20.500.12708/152800</div> </div>

http://hdl.handle.net/20.500.12708/152800

Diffraction limits in mid-IR microscopy – Technological progress over the last decade has in large part been contingent of understanding, designing and controlling materials and devices at ever smaller length scales. As theses length scales keeping going down established analytical chemistry tools end up not being able to resolve them anymore. For example, while mid-IR spectroscopy coupled to an optical microscope is a great tool for rapid chemical imaging at the millimetre and micrometre scale, it relies on the interaction of micron range (2 µm to 20 µm) electromagnetic radiation with the specimen. Hence, the diffraction limit prevents us from building mid-IR optical microscopes that can resolve structures on the nanoscale. Chemical imaging below the diffraction limit – We can circumvent the diffraction limit by building a nearfield imaging system, i.e., by moving the detector and/or the light source as close to our specimen as possible. One approach to move the “detector” closer that has found wide acceptance for mid-IR spectroscopy is to use photothermal expansion induced by a tuneable pulsed laser for detection of local absorption. This PTIR (photothermal induced resonance) or AFM-IR (atomic force microscopy induced resonance) technique reads the local thermal expansion using an AFM tip to enable nanometre scale spatial resolution chemical imaging. AFM-IR can be used to collect mid-IR absorption spectra from nanoscale samples that resemble conventional bulk spectra and it can be used to image the chemical makeup of the sample at nanoscale lateral resolution without the need for labelling or staining [1]. Within the last decade AFM-IR has found applications across fields and disciplines, from microbiology [2] and medicine [3] to polymer science [4] and material science [5]. AFM-IR has been used to study the secondary structure of peptides in water [6] and to detect a chemotherapeutic at the zeptomole level inside a nanoscale drug carrier [7]. AFM-IR can also be used to determine thermal conductivity and interfacial thermal resistance at the nanoscale [8]. Nanoscale chemical imaging – One of the most exciting aspects of AFM-IR is that it can be used to apply multivariate chemical imaging techniques that are well established for IR microscopy at the nanoscale. These enable to combine information from multiple spectra or multiple single wavelength images into actual maps of chemical composition (see fig. 1) – if we are doing it right. “Doing it right” requires an understanding of the signal transduction chain in AFM-IR and the peculiarities of scanning probe microscopy. It also requires to understand optical effects that limit the linear range of AFM-IR [9]. This presentation will discuss the AFM-IR signal transduction chain and which of its parameters can (need to be) controlled to achieve reproducible AFM-IR measurements and what the particular challenges are in applying chemometric algorithms to AFM-IR datasets.

European Commission

European Commission

FFG - Österr. Forschungsförderungs- gesellschaft mbH

en

AFM-IR

imaging

QCL

nanoscale

Photothermal spectroscopy for nanoscale chemical imaging

Presentation

Vortrag

8619858

953234

868615

Keynote Presentation

High-Performance Large Area Organic Perovskite devices for lighting, energy and Pervasive Communications

Tumor und Lymphknoten auf einer Chip Plattform für Krebsstudien

Chemical Systems Engineering

M2

M6

M5

Materials Characterization

Biological and Bioactive Materials

Composite Materials

40

20

40

E164-02-1 - Forschungsgruppe Prozessanalytik

0000-0001-8307-5435

0000-0001-6342-2823

0000-0002-2675-739X

0000-0003-3838-5842

ICPPP21

19-06-2022

24-06-2022

On Site

Event for scientific audience

Bled

SI

Univweaity of Nova Goricia, University of Ljubljana, Jzef Stefan Institute

Ramer, Georg

Multi Track

Chemie

Physik, Astronomie

1040

1030

80

20

en

conference paper not in proceedings

none

no Fulltext

Publications

http://purl.org/coar/resource_type/c_18cp

E164-02-1 - Forschungsgruppe Prozessanalytik

E164-02-1 - Forschungsgruppe Prozessanalytik

E164-02-1 - Forschungsgruppe Prozessanalytik

E164-02-1 - Forschungsgruppe Prozessanalytik

E164-02-1 - Forschungsgruppe Prozessanalytik

E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren

0000-0001-8307-5435

0000-0001-6342-2823

0009-0009-3572-5267

0009-0006-0703-9524

0000-0002-2675-739X

0000-0003-3838-5842

E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren

E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren

E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren

E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren

E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren

E164 - Institut für Chemische Technologien und Analytik

European Commission

European Commission

FFG - Österr. Forschungsförderungs- gesellschaft mbH

8619858

953234

868615