<div class="csl-bib-body">
<div class="csl-entry">Reinfurt, A., Ellena, V., & Steiger, M. (2022, March 15). <i>cexA and its regulatory processes - the manganese mistery of A. niger</i> [Poster Presentation]. 31st Fungal Genetics Conference, Pacific Grove, CA, USA, United States of America (the). http://hdl.handle.net/20.500.12708/153824</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/153824
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dc.description.abstract
cexA and its regulatory processes – a closer look into the citric acid production
mechanisms of Aspergillus niger
Authors: Aline Reinfurt, Valeria Ellena, Matthias G. Steiger
Aspergillus niger is an important filamentous fungus used for the industrial production
of citric acid. One of the main contributors to high citric acid accumulation by the
fungus is the citrate transporter CexA. It belongs to the major faciliatory superfamily
subclass DHA1 which act as drug-H+ antiporters1. Since cexA and its regulators are
essential within the citric acid production process, it is important to study their
regulatory mechanism, which is the focus of this work. LaeA for one is known to be a
major regulator of the cexA gene. It regulates the expression via methylation levels of
the histones H3K4 and H3K92. There are indications that other transcriptional
regulators such as AmyR and XlnR are also involved in the regulation of cexA on a
transcriptional level. Another factor that affects citric acid production is the amount of
manganese that is present during the production process. Observations showed that
the fungus develops a certain pellet-like morphology under manganese limitation
conditions and that this limitation is decisive for high citric acid accumulation by A.
niger3,4. However, the exact mode of action of manganese in the cell is not clear. The
transcriptional influence of manganese on cexA and laeA is investigated in order to
find out more about the connection between manganese limitation and citric acid
production.
en
dc.description.sponsorship
FFG - Österr. Forschungsförderungs- gesellschaft mbH
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dc.language.iso
en
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dc.subject
cexA
en
dc.subject
manganese regulation
en
dc.subject
citric acid
en
dc.title
cexA and its regulatory processes - the manganese mistery of A. niger
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
Austrian Centre of Industrial Biotechnology (Austria), Austria
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dc.relation.grantno
93031
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dc.type.category
Poster Presentation
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tuw.project.title
Genetik und Engineering von Aspergillus niger
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tuw.researchTopic.id
X1
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tuw.researchTopic.name
Beyond TUW-research foci
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tuw.researchTopic.value
100
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tuw.publication.orgunit
E166-05-2 - Forschungsgruppe Biochemie
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tuw.publication.orgunit
E166 - Institut für Verfahrenstechnik, Umwelttechnik und technische Biowissenschaften
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tuw.author.orcid
0000-0001-7907-1861
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tuw.author.orcid
0000-0001-9781-434X
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tuw.author.orcid
0000-0002-8985-2343
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tuw.event.name
31st Fungal Genetics Conference
en
tuw.event.startdate
15-03-2022
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tuw.event.enddate
20-03-2022
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Pacific Grove, CA, USA
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tuw.event.country
US
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tuw.event.presenter
Reinfurt, Aline
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tuw.event.track
Multi Track
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wb.sciencebranch
Biologie
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wb.sciencebranch
Industrielle Biotechnologie
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wb.sciencebranch.oefos
1060
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wb.sciencebranch.oefos
2090
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wb.sciencebranch.value
50
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wb.sciencebranch.value
50
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
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item.grantfulltext
restricted
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item.languageiso639-1
en
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item.cerifentitytype
Publications
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item.fulltext
no Fulltext
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item.openairetype
conference poster not in proceedings
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crisitem.project.funder
FFG - Österr. Forschungsförderungs- gesellschaft mbH
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crisitem.project.grantno
93031
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crisitem.author.dept
Austrian Centre of Industrial Biotechnology (Austria)
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crisitem.author.dept
E166-05-2 - Forschungsgruppe Mikrobiologie und Angewandte Genomik
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crisitem.author.orcid
0000-0002-8985-2343
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crisitem.author.parentorg
E166-05 - Forschungsbereich Biochemische Technologie
