<div class="csl-bib-body">
<div class="csl-entry">Spörl, F. C. (2020). <i>Development of a microgripper for a collagen fibril tension test</i> [Diploma Thesis, Technische Universität Wien]. reposiTUm. https://doi.org/10.34726/hss.2020.60843</div>
</div>
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dc.identifier.uri
https://doi.org/10.34726/hss.2020.60843
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/15581
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dc.description.abstract
Fibrillar collagens are the most abundant structural proteins in humans. They are major constituents in connective tissues like tendon, skin, bone, and the vasculature, where they largely determine the mechanical behaviour. Deterioration of collagen is linked to several widespread diseases like arteriosclerosis or tendinopathy, which result in impaired tissue mechanics. In this context, the macromechanics of collagenous tissues are reasonably well understood, but many aspects of the unique mechanical properties of collagen fibrils, which represent the smallest microscopical structural unit, remain unknown. To obtain a better understanding of collagen fibril mechanics, get insights into the microscopic principles that govern the strength of connective tissues, as well as understanding the importance of collagen cross-linking, tensile tests are conducted on collagen fibrils. However, so far no standardized test procedure has been established. No experiments with high statistical relevance have been conducted, due to shortcomings in current testing methods, which result in very laborious and costly experiments. As part of a project with the overall goal to significantly reduce the cycle time for collagen fibril tension tests compared to current methods, a micro gripper for collagen fibrils has been developed in this diploma thesis. The fabrication of the gripper designs was carried out by means of two-photon polymerization (2PP). Various designs were fabricated, examined for geometric and structural integrity and checked for capability through qualitative tensile tests of collagen fibrils. The project also included the generation of a finite element model for validation of the gripper design with respect to structural integrity under load. A series of parameters were established to assess the capability of the micro gripper in silico and give insights into the expected magnitudes of errors compared to the current methods. It was found that the utilization of a micro gripper for collagen fibril tension tests does not significantly falsify the measurements and can therefore be used for future experiments.
en
dc.language
English
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dc.language.iso
en
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dc.rights.uri
http://rightsstatements.org/vocab/InC/1.0/
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dc.subject
Collagen Mechanics
en
dc.subject
Equipment Design
en
dc.title
Development of a microgripper for a collagen fibril tension test
en
dc.type
Thesis
en
dc.type
Hochschulschrift
de
dc.rights.license
In Copyright
en
dc.rights.license
Urheberrechtsschutz
de
dc.identifier.doi
10.34726/hss.2020.60843
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dc.contributor.affiliation
TU Wien, Österreich
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dc.rights.holder
Felix Christoph Spörl
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dc.publisher.place
Wien
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tuw.version
vor
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tuw.thesisinformation
Technische Universität Wien
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dc.contributor.assistant
Ovsianikov, Aleksandr
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tuw.publication.orgunit
E317 - Institut für Leichtbau und Struktur-Biomechanik
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dc.type.qualificationlevel
Diploma
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dc.identifier.libraryid
AC15751466
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dc.description.numberOfPages
124
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dc.thesistype
Diplomarbeit
de
dc.thesistype
Diploma Thesis
en
dc.rights.identifier
In Copyright
en
dc.rights.identifier
Urheberrechtsschutz
de
tuw.advisor.staffStatus
staff
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tuw.assistant.staffStatus
staff
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tuw.advisor.orcid
0000-0001-7588-9041
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tuw.assistant.orcid
0000-0001-5846-0198
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item.languageiso639-1
en
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item.mimetype
application/pdf
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item.openairecristype
http://purl.org/coar/resource_type/c_bdcc
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item.fulltext
with Fulltext
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item.openairetype
master thesis
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item.grantfulltext
open
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item.openaccessfulltext
Open Access
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item.cerifentitytype
Publications
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crisitem.author.dept
E317 - Institut für Leichtbau und Struktur-Biomechanik
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crisitem.author.parentorg
E300 - Fakultät für Maschinenwesen und Betriebswissenschaften