<div class="csl-bib-body">
<div class="csl-entry">Tzanetou, E., Kasiotis, K., Thomaidis, N. S., & Rosenberg, E.-E. (2013). Determination of Trace Inorganic Germanium in bis-beta-Carboxyethylgermanium Sesquioxide by Headspace Solid-Phase Microextraction and Gas Chromatography – Mass Spectrometry. <i>Current Analytical Chemistry</i>, <i>9</i>(2), 244–249. https://doi.org/10.2174/157341113805218938</div>
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dc.identifier.issn
1573-4110
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/156245
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dc.description.abstract
Organic germanium compounds, such as bis-beta-carboxyethylgermanium sesquioxide ("Ge-132"), have attained widespread distribution â-" particularly in self-medication â-" and are applied as tonics due to their presumed anticancer activities. In general, the toxicity of this particular organo-germanium compound is low. In contrast to this, acute and chronic toxic effects of inorganic germanium dioxide (GeO2) have been demonstrated. In this paper, chloride-generation headspace solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS) is proposed as a technique for the determination of trace amounts of GeO2 in Ge-132. This method takes advantage of the fact that Ge-132 is not able to generate volatile species upon reaction with conc. HCl. The conditions for the generation of germanium chloride (GeCl4), such as SPME fibre selection, extraction time and HCl concentration were investigated. The detection limit was established at 0.28 μg/ml (as Ge). Thus, this approach provides a novel, simple and fast platform for the determination of inorganic Ge in organogermanium formulations.
en
dc.language.iso
en
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dc.publisher
BENTHAM SCIENCE PUBL LTD
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dc.relation.ispartof
Current Analytical Chemistry
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dc.subject
Analytical Chemistry
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dc.subject
SPME
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dc.subject
GC-MS
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dc.subject
speciation
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dc.subject
Ge-132
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dc.subject
Germanium dioxide
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dc.subject
chloride generation
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dc.title
Determination of Trace Inorganic Germanium in bis-beta-Carboxyethylgermanium Sesquioxide by Headspace Solid-Phase Microextraction and Gas Chromatography – Mass Spectrometry
en
dc.type
Artikel
de
dc.type
Article
en
dc.contributor.affiliation
Benaki Phytopathological Institute (BPI)
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dc.description.startpage
244
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dc.description.endpage
249
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dc.type.category
Original Research Article
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tuw.container.volume
9
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tuw.container.issue
2
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tuw.journal.peerreviewed
true
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tuw.peerreviewed
true
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tuw.researchTopic.id
X1
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tuw.researchTopic.name
außerhalb der gesamtuniversitären Forschungsschwerpunkte
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tuw.researchTopic.value
100
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dcterms.isPartOf.title
Current Analytical Chemistry
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tuw.publication.orgunit
E164-01-2 - Forschungsgruppe Oberflächen-, Spurenanalytik und Chemometrie