<div class="csl-bib-body">
<div class="csl-entry">Werkmeister, R. M., Dragostinoff, N., Palkovits, S., Told, R., Boltz, A., Leitgeb, R. A., Gröschl, M., Garhöfer, G., & Schmetterer, L. (2012). Measurement of Absolute Blood Flow Velocity and Blood Flow in the Human Retina by Dual-Beam Bidirectional Doppler Fourier-domain Optical Coherence Tomography. <i>Investigative Ophthalmology & Visual Science</i>, <i>53</i>(10), 6062. https://doi.org/10.1167/iovs.12-9514</div>
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dc.identifier.issn
0146-0404
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/164211
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dc.description.abstract
PURPOSE. The present experiments were undertaken to evaluate the validity of absolute flow velocity measurements with a dual-beam bidirectional Doppler Fourier-domain optical coherence tomography (FD-OCT) system.
METHODS. The flow velocities of diluted milk through a glass capillary were measured at 30 different preset velocities in the range of 0.9 to 39.3 mm/s by bidirectional Doppler FD-OCT. The flow through the capillary was controlled by two infusion pumps working in different flow ranges and based on different technical principles. In vivo the validity of the method for measuring blood flow in retinal vessels was tested at bifurcations. The continuity equation was verified at 10 retinal venous bifurcations of 10 young healthy subjects (mean age, 29 ± 3 years) by velocity measurements, using dual-beam bidirectional Doppler FD-OCT, and measurements of retinal diameters, using the Dynamic Vessel Analyzer. RESULTS. Flow velocities as measured with bidirectional Doppler FD-OCT in the glass capillary were in good agreement with the preset velocities (r = 0.994, P < 0.001 each). No significant difference was found between flow in the trunk vessels before the bifurcation (11.3 ± 5.2 µL/min) and the sum of flows in the daughter vessels (10.7 ± 4.8 µL/min). A significant association was found between retinal vessel diameters and both retinal blood velocities (r = 0.72, P < 0.001) and retinal blood flow (r = 0.95, P < 0.0001).
CONCLUSIONS. Dual-beam bidirectional Doppler FD-OCT delivered accurate retinal blood velocity values and, thus, offers high potential for examination of retinal blood flow in ocular disease.
en
dc.language.iso
en
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dc.publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
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dc.relation.ispartof
Investigative Ophthalmology & Visual Science
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dc.subject
General Medicine
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dc.title
Measurement of Absolute Blood Flow Velocity and Blood Flow in the Human Retina by Dual-Beam Bidirectional Doppler Fourier-domain Optical Coherence Tomography
en
dc.type
Artikel
de
dc.type
Article
en
dc.description.startpage
6062
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dc.type.category
Original Research Article
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tuw.container.volume
53
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tuw.container.issue
10
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tuw.journal.peerreviewed
true
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tuw.peerreviewed
true
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tuw.researchTopic.id
M2
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tuw.researchTopic.name
Materials Characterization
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tuw.researchTopic.value
100
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dcterms.isPartOf.title
Investigative Ophthalmology & Visual Science
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tuw.publication.orgunit
E134-01 - Forschungsbereich Applied and Computational Physics