<div class="csl-bib-body">
<div class="csl-entry">Matic, J., & Khinast, J. (2020). Simulation Aided Pharmaceutical Hot Melt Extrusion Process Understanding, Setup and Scale-up. In C. Jordan (Ed.), <i>Proceedings of the 16th Minisymposium Verfahrenstechnik and 7th Partikelforum (TU Wien, Sept. 21/22, 2020)</i> (pp. DiV2-(03) page 1-DiV2-(03) page 5). chemical-engineering.at. https://doi.org/10.34726/596</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/16656
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dc.identifier.uri
https://doi.org/10.34726/596
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dc.description.abstract
During the pharmaceutical product development it is important, especially in the early phases, on get a good idea on the processability of the candidate formulations. Especially for hot melt extrusion (HME) based formulations choosing the appropriate equipment and process setup that will result in the desired product quality is not trivial. Especially significant in the early phases of the product development cycle, where typically only small amounts of active pharmaceutical ingredients (API) are available (often in the rage of couple of grams only), it is crucial to still be able to give educated guesses on the processability of the formulation, the expected product quality and, ideally, being able to propose candidate process setups. In order to fulfil the goals mentioned above, development of formulation and process specific knowledge is required, as well as development of potent in silico methodologies capable of mirroring the actual process itself. This work focuses on the development of suitable in silico tools for the accurate HME process capturing, extended experimental investigations and product quality correlation and prediction.
en
dc.language.iso
en
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.subject
Pharmaceutical HME
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dc.subject
Product Quality
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dc.subject
scale-up
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dc.subject
SPH
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dc.subject
Mechanistic Modeling
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dc.title
Simulation Aided Pharmaceutical Hot Melt Extrusion Process Understanding, Setup and Scale-up
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dc.type
Inproceedings
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dc.type
Konferenzbeitrag
de
dc.rights.license
Creative Commons Namensnennung 4.0 International
de
dc.rights.license
Creative Commons Attribution 4.0 International
en
dc.identifier.doi
10.34726/596
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dc.contributor.affiliation
TU Graz, Austria
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dc.contributor.affiliation
TU Graz, Austria
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dc.relation.isbn
978-3-903337-01-5
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dc.relation.doi
10.34726/541
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dc.description.startpage
DiV2-(03) page 1
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dc.description.endpage
DiV2-(03) page 5
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dcterms.dateSubmitted
2020-02-28
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dc.type.category
Full-Paper Contribution
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tuw.booktitle
Proceedings of the 16th Minisymposium Verfahrenstechnik and 7th Partikelforum (TU Wien, Sept. 21/22, 2020)