DC FieldValueLanguage
dc.contributor.authorRen, Tanchen-
dc.contributor.authorSteiger, Wolfgang-
dc.contributor.authorChen, Pu-
dc.contributor.authorOvsianikov, Aleksandr-
dc.contributor.authorDemirci, Utkan-
dc.date.accessioned2021-02-15T09:03:49Z-
dc.date.available2021-02-15T09:03:49Z-
dc.date.issued2020-03-31-
dc.identifier.issn1758-5082-
dc.identifier.urihttp://hdl.handle.net/20.500.12708/16842-
dc.description.abstractHow to pack materials into well-defined volumes efficiently has been a longstanding question of interest to physicists, material scientists, and mathematicians as these materials have broad applications ranging from shipping goods in commerce to seeds in agriculture and to spheroids in tissue engineering. How many marbles or gumball candies can you pack into a jar? Although these seem to be idle questions they have been studied for centuries and have recently become of greater interest with their broadening applications in science and medicine. Here, we study a similar problem where we try to pack cells into a spherical porous buckyball structure. The experimental limitations are short of the theoretical maximum packing density due to the microscale of the structures that the cells are being packed into. We show that we can pack more cells into a confined micro-structure (buckyball cage) by employing acoustofluidic activation and their hydrodynamic effect at the bottom of a liquid-carrier chamber compared to randomly dropping cells onto these buckyballs by gravity. Although, in essence, cells would be expected to achieve a higher maximum volume fraction than marbles in a jar, given that they can squeeze and reshape and reorient their structure, the packing density of cells into the spherical buckyball cages are far from this theoretical limit. This is mainly dictated by the experimental limitations of cells washing away as well as being loaded into the chamber.-
dc.description.sponsorshipEuropean Research Council (ERC)-
dc.description.sponsorshipAustrian Science Fund (FWF)-
dc.language.isoen-
dc.publisherIOP PUBLISHING LTD-
dc.relation.ispartofBiofabrication-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectnetworks of neuronsen
dc.titleEnhancing cell packing in buckyballs by acoustofluidic activationen
dc.typeArticleen
dc.typeArtikelde
dc.rights.licenseCreative Commons Namensnennung 4.0 Internationalde
dc.rights.licenseCreative Commons Attribution 4.0 Internationalen
dc.identifier.pmid32229710-
dc.identifier.scopus2-s2.0-85082791426-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85082791426-
dc.contributor.affiliationStanford School of Medicine, United States of America-
dc.contributor.affiliationWuhan University School of Basic Medical Sciences, People's Republic of China-
dc.contributor.affiliationStanford School of Medicine, United States of America-
dc.description.startpage1-
dc.description.endpage7-
dc.relation.grantno772464-
dc.relation.grantnoI 2444-
dcterms.dateSubmitted2019-08-25-
dc.type.categoryOriginal Research Article-
tuw.container.volume12-
tuw.container.issue2-
tuw.journal.peerreviewedtrue-
tuw.peerreviewedtrue-
tuw.versionvor-
tuw.project.titleThird Strategy in Tissue Engineering – Functional microfabricated multicellular spheroid carriers for tissue engineering and regeneration-
tuw.project.titleNeuartige zell-instruktive Hydrogele für laser-basiertes hochauflösendes 3D Drucken-
dcterms.isPartOf.titleBiofabrication-
tuw.publication.orgunitE308-02-3 - Forschungsgruppe 3D Printing and Biofabrication-
tuw.publisher.doi10.1088/1758-5090/ab76d9-
dc.identifier.articleid025033-
dc.identifier.eissn1758-5090-
dc.description.numberOfPages7-
tuw.author.orcid0000-0002-3382-7042-
tuw.author.orcid0000-0001-5846-0198-
tuw.author.orcid0000-0003-2784-1590-
dc.rights.identifierCC BY 4.0de
dc.rights.identifierCC BY 4.0en
item.grantfulltextopen-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairetypeArtikel-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextwith Fulltext-
crisitem.author.deptStanford School of Medicine, United States of America-
crisitem.author.deptWuhan University School of Basic Medical Sciences, People's Republic of China-
crisitem.author.deptStanford School of Medicine, United States of America-
crisitem.author.orcid0000-0001-5846-0198-
crisitem.author.orcid0000-0003-2784-1590-
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