<div class="csl-bib-body">
<div class="csl-entry">Höhlschen, J. M., Hofreither, D., Tomin, T., & Birner-Grünberger, R. (2023, July 30). <i>Effects of gliflozins on proteome of cardiomyocytes</i> [Poster Presentation]. FEBS 2023 Advanced Course: 15th European Summer School Advanced Proteomics, Brixen, Italy. http://hdl.handle.net/20.500.12708/188042</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/188042
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dc.description.abstract
Death from cardiovascular (CV) diseases is the most relevant macrovascular complication in type 2 diabetes. A new drug class that offers cardioprotective properties are sodium-glucose co-transporter-2 (SGLT-2) inhibitors, initially used for the treatment of type 2 diabetes. Meanwhile trials have shown that these properties are beyond the effect of lowering glucose concentrations in the blood. Therefore, their application in non-diabetic patients suffering from heart diseases has recently been approved.
Even though cardiovascular events as heart failure are multicausal, the disbalance in reactive oxygen species (ROS) - and antioxidant potential of the tissue also defined as oxidative stress - is one relevant aspect in the development of heart failure. As gliflozins are reported to exhibit antioxidative effect in cardiac tissue, our goal was to unravel the underlying mechanism. To that end differentiated, human cardiomyocyte cell line (AC-16) was treated with three commercially available gliflozins (Dapa-, Cana- and Empagliflozin) in settings mimicking disruption of oxygen supply (similar to heart failure): 1% oxygen (hypoxia), 21% oxygen (Control) and reperfusion injury (1% followed by re-oxygenation at 21% oxygen). A similar experimental setup was done in stem-cell derived cardioids to increase the translational aspect. Quantitative and redox proteomic methods are applied to monitor the influence of the drugs at the different oxygen availabilities.
en
dc.description.sponsorship
European Commission
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dc.description.sponsorship
FWF Fonds zur Förderung der wissenschaftlichen Forschung (FWF)
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dc.language.iso
en
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dc.subject
gliflozin
en
dc.subject
heart disease
en
dc.subject
redox stress
en
dc.title
Effects of gliflozins on proteome of cardiomyocytes
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.relation.grantno
101034277
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dc.relation.grantno
F 7309-B21
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dc.type.category
Poster Presentation
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tuw.project.title
Technik für Biowissenschaften Doktoratsstudium
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tuw.project.title
Lipidhydrolyse im Krebs und in Lipid-assoziierten Krankheiten
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
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tuw.publication.orgunit
E164-01-3 - Forschungsgruppe Bioanalytik
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tuw.publication.orgunit
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
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tuw.author.orcid
0000-0002-7071-2316
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tuw.author.orcid
0000-0003-3950-0312
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tuw.event.name
FEBS 2023 Advanced Course: 15th European Summer School Advanced Proteomics
en
tuw.event.startdate
30-07-2023
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tuw.event.enddate
05-08-2023
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Brixen
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tuw.event.country
IT
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tuw.event.presenter
Höhlschen, Julia Martina
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tuw.event.track
Single Track
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wb.sciencebranch
Chemie
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wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
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wb.sciencebranch.oefos
1040
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wb.sciencebranch.oefos
3012
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wb.sciencebranch.value
50
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wb.sciencebranch.value
50
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item.fulltext
no Fulltext
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item.cerifentitytype
Publications
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item.cerifentitytype
Publications
-
item.languageiso639-1
en
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item.openairetype
Presentation
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item.openairetype
Vortrag
-
item.openairecristype
http://purl.org/coar/resource_type/c_18cf
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item.openairecristype
http://purl.org/coar/resource_type/c_18cf
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item.grantfulltext
restricted
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crisitem.project.funder
European Commission
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crisitem.project.funder
FWF Fonds zur Förderung der wissenschaftlichen Forschung (FWF)
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crisitem.project.grantno
101034277
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crisitem.project.grantno
F 7309-B21
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crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
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crisitem.author.orcid
0000-0002-7071-2316
-
crisitem.author.orcid
0000-0003-3950-0312
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
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crisitem.author.parentorg
E164 - Institut für Chemische Technologien und Analytik