<div class="csl-bib-body">
<div class="csl-entry">Honeder, S., Tomin, T., Abbott, K., Schittmayer-Schantl, M., Vander Heiden, M., & Birner-Grünberger, R. (2023, September 17). <i>Lipid hydrolysis enzymes in cancer metabolism: Unravelling the intricacies of cellular adaptation in lung cancer</i> [Poster Presentation]. ISCaM 2023 meeting - 10th Annual Meeting, London, United Kingdom of Great Britain and Northern Ireland (the). http://hdl.handle.net/20.500.12708/189174</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/189174
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dc.description.abstract
Cancer cells frequently employ metabolic adaptations to sustain proliferation in challenging microenvironments. Recent research has shed light on the significance of lipid metabolism in cancer progression. Heightened rates of de novo fatty acid synthesis or increased uptake of fatty acids are frequently observed in cancer cells. However, the role of lipid catabolism, specifically the breakdown of lipids stored in lipid droplets, in cancer remains relatively understudied.
Our study focuses on the involvement of adipose triglyceride lipase (ATGL) and monoglyceride lipase (MGL) in lung cancer. ATGL is responsible for initiating triglyceride breakdown, and its potential role in lung cancer development has been suggested, considering the observed accumulation of lipid droplets in solid tumours. MGL, another key lipase involved in intracellular lipid degradation, has been shown to impact signalling pathways and influence cancer pathogenesis.
Through genetic manipulation of lipid hydrolases in a panel of non-small cell lung cancer (NSCLC) cell lines we aim to explore the role of these enzymes in cellular metabolism.
Our preliminary findings indicate that deletion of either ATGL or MGL in some but not all NSCLC cell lines results in increased proliferation and metabolic changes.
Our primary objective is to unravel the intricate interplay between lipid hydrolysis enzymes, lung cancer cell metabolism, and proliferation. By gaining a deeper understanding of these mechanisms, we aim to shed light on the factors driving lung cancer progression and identify new dependencies of lung cancer cells. This knowledge holds the potential to unlock novel avenues for targeted therapies and personalized treatment strategies.
en
dc.description.sponsorship
FWF Fonds zur Förderung der wissenschaftlichen Forschung (FWF)
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dc.language.iso
en
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dc.subject
cancer
en
dc.subject
proteomics
en
dc.subject
lipase
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dc.title
Lipid hydrolysis enzymes in cancer metabolism: Unravelling the intricacies of cellular adaptation in lung cancer
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
Medical University of Graz, Austria
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dc.contributor.affiliation
Koch Institute for Integrative Cancer Research At MIT, United States of America (the)
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dc.contributor.affiliation
Massachusetts Institute of Technology, United States of America (the)
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dc.relation.grantno
F 7309-B21
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dc.type.category
Poster Presentation
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tuw.project.title
Lipidhydrolyse im Krebs und in Lipid-assoziierten Krankheiten
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
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tuw.linking
https://iscam.net/en/meetings/
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tuw.publication.orgunit
E164-01-3 - Forschungsgruppe Bioanalytik
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tuw.author.orcid
0000-0002-7201-6293
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tuw.author.orcid
0000-0002-7071-2316
-
tuw.author.orcid
0000-0003-3249-655X
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tuw.author.orcid
0000-0002-6702-4192
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tuw.author.orcid
0000-0003-3950-0312
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tuw.event.name
ISCaM 2023 meeting - 10th Annual Meeting
en
tuw.event.startdate
17-09-2023
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tuw.event.enddate
19-09-2023
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
London
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tuw.event.country
GB
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tuw.event.presenter
Honeder, Sophie
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wb.sciencebranch
Chemie
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wb.sciencebranch
Biologie
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wb.sciencebranch
Anatomie, Pathologie, Physiologie
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wb.sciencebranch.oefos
1040
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wb.sciencebranch.oefos
1060
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wb.sciencebranch.oefos
3011
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wb.sciencebranch.value
40
-
wb.sciencebranch.value
30
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wb.sciencebranch.value
30
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item.languageiso639-1
en
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item.openairetype
conference poster not in proceedings
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item.grantfulltext
restricted
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item.fulltext
no Fulltext
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item.cerifentitytype
Publications
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
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crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
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crisitem.author.dept
Massachusetts Institute of Technology
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crisitem.author.dept
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
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crisitem.author.orcid
0000-0002-7071-2316
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crisitem.author.orcid
0000-0002-6166-704X
-
crisitem.author.orcid
0000-0003-3249-655X
-
crisitem.author.orcid
0000-0002-6702-4192
-
crisitem.author.orcid
0000-0003-3950-0312
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
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crisitem.author.parentorg
E164 - Institut für Chemische Technologien und Analytik
