<div class="csl-bib-body">
<div class="csl-entry">Baumgartner, T., Bösenhofer, M., Guillaume, O., Ovsianikov, A., Harasek, M., & Gföhler, M. (2023). How do sinusoidal scaffolds affect fluid flow-induced wall shear stress and mass transport? In <i>ESB 2023 : 28th Congress of the European Society of Biomechanics : Book of Abstracts</i> (pp. 85–85). European Society of Biomechanics.</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/189391
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dc.description.abstract
Bone is one of the most transplanted tissues. About 1.6 million bone grafts are performed each year only in the United States [1]. This treatment has serious drawbacks, such as a higher risk of infections or even donor site morbidities. Therefore, an alternative is the use of scaffolds to create bone tissue. The role of scaffolds in bone tissue engineering is to mimic the native bone tissue and is used to provide a template that supports seeded cells to get an optimal environment for their proliferation [2] to re-build the damaged structure. Hence, an optimal scaffold design is important and must be found because even small changes in the geometry of the pore network of the scaffold influences the process of cell growth and mechanical properties [2,3]. Wall shear stress (WSS) has a significant role in the differentiation of cells, especially for bone. Even minor changes in the flow field, especially near the wall regions, can directly affect cell bioactivity. Therefore, in this work, we use computational fluid dynamics (CFD) simulations to investigate the WSS and the effect of the flow rate on mass transport rates in scaffolds. The numerical results were compared to µ-particle image velocimetry (PIV) experiments to evaluate the reliability of the CFD method.
en
dc.language.iso
en
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dc.subject
scaffolds
en
dc.subject
bone tissue
en
dc.subject
CFD
en
dc.subject
wall shear stress
en
dc.subject
PIV
en
dc.title
How do sinusoidal scaffolds affect fluid flow-induced wall shear stress and mass transport?
en
dc.type
Inproceedings
en
dc.type
Konferenzbeitrag
de
dc.description.startpage
85
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dc.description.endpage
85
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dc.type.category
Abstract Book Contribution
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tuw.booktitle
ESB 2023 : 28th Congress of the European Society of Biomechanics : Book of Abstracts
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tuw.relation.publisher
European Society of Biomechanics
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tuw.researchTopic.id
C2
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tuw.researchTopic.id
C3
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tuw.researchTopic.name
Computational Fluid Dynamics
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tuw.researchTopic.name
Computational System Design
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tuw.researchTopic.value
70
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tuw.researchTopic.value
30
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tuw.publication.orgunit
E307-03 - Forschungsbereich Biomechanik und Rehabilitationstechnik