<div class="csl-bib-body">
<div class="csl-entry">Kattukudiyil Narayanan, N., Pittenauer, E., & Schnürch, M. (2023). 2‐(o‐Tolyl) Pyridine as Ligand Improves the Efficiency in Ketone Directed ortho‐Arylation. <i>European Journal of Organic Chemistry</i>, <i>26</i>(42), Article e202300759. https://doi.org/10.1002/ejoc.202300759</div>
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dc.identifier.issn
1434-193X
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/191042
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dc.description.abstract
Herein, we report a ruthenium-catalyzed ketone directed ortho-arylation wherein the addition of a bidentate NC-type ligand, most effectively 2-(o-tolyl) pyridine, significantly enhances the C−H arylation reaction. Various aryl-alkyl ketones, including cyclic, aliphatic, and heterocyclic ones, are competent substrates, and arylboronic acid esters were used as aryl sources. However, substitution with OMe and CF₃ in the aromatic ring of the ketone substrates is not tolerated, while such residues on the benzoic ester are possible. Notably, this study provides valuable insights into ketone-directed ortho arylation in the presence of 2-(o-tolyl) pyridine and adds additional options for catalyst and ligand optimization in ruthenium-catalyzed C−H functionalization.
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dc.description.sponsorship
European Commission
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dc.language.iso
en
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dc.publisher
Wiley
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dc.relation.ispartof
European Journal of Organic Chemistry
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dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
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dc.subject
Cyclometallated complex
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dc.subject
C−H activation
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dc.subject
Directing group
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dc.subject
Ketone directed ortho-arylation
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dc.subject
Ligand
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dc.title
2‐(o‐Tolyl) Pyridine as Ligand Improves the Efficiency in Ketone Directed ortho‐Arylation
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dc.type
Article
en
dc.type
Artikel
de
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
en
dc.rights.license
Creative Commons Namensnennung - Nicht kommerziell 4.0 International