<div class="csl-bib-body">
<div class="csl-entry">Summer, S., Kocsis, A., Reihs, E. I., Rothbauer, M., Lonhus, K., Stys, D., Ertl, P., & Fischer, M. B. (2023). Automated analysis of mitochondrial dimensions in mesenchymal stem cells: Current methods and future perspectives. <i>Heliyon</i>, <i>9</i>(1), e12987. https://doi.org/10.1016/j.heliyon.2023.e12987</div>
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dc.identifier.issn
2405-8440
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/191398
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dc.description.abstract
As centre of energy production and key regulators of metabolic and cellular signaling pathways, the integrity of mitochondria is essential for mesenchymal stem cell function in tissue regeneration. Alterations in the size, shape and structural organization of mitochondria are correlated with the physiological state of the cell and its environment and could be used as diagnostic biomarkers. Therefore, high-throughput experimental and computational techniques are crucial to ensure adequate correlations between mitochondrial function and disease phenotypes. The emerge of microfluidic technologies can address the shortcomings of traditional methods to determine mitochondrial dimensions for diagnostic and therapeutic use. This review discusses optical detection methods compatible with microfluidics to measure mitochondrial dynamics and their potential for clinical stem cell research targeting mitochondrial dysfunction.
en
dc.language.iso
en
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dc.publisher
CELL PRESS
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dc.relation.ispartof
Heliyon
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dc.subject
Automated mitochondrial analysis
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dc.subject
MSC-Based therapies
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dc.subject
Mesenchymal stem cells
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dc.subject
Microfluidic systems
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dc.subject
Mitochondrial dynamics
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dc.title
Automated analysis of mitochondrial dimensions in mesenchymal stem cells: Current methods and future perspectives
