<div class="csl-bib-body">
<div class="csl-entry">Wilkovitsch, M., Svatunek, D., Mikula, H., & Denk, C. (2023). Post-radiolabeling thioether oxidation to enhance the bioorthogonal reactivity of <sup>1</sup><sup>8</sup>F-tetrazines. <i>MONATSHEFTE FUR CHEMIE</i>, <i>154</i>(12), 1441–1457. https://doi.org/10.1007/s00706-023-03140-w</div>
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dc.identifier.issn
0026-9247
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/192095
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dc.description.abstract
Radiolabeled 1,2,4,5-tetrazines are powerful heterocyclic agents for bioorthogonal PET imaging due to their fast cycloaddition with trans-cyclooctenes. However, fluorine-18 radiolabeling of highly reactive tetrazines is often not feasible due to limited compound stability. We demonstrate that post-radiolabeling oxidation of thioether functionalities is a viable and transferable strategy to avoid these limitations, enabling the synthesis of highly reactive 18F-tetrazines.
en
dc.description.sponsorship
European Commission
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dc.language.iso
en
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dc.publisher
SPRINGER WIEN
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dc.relation.ispartof
MONATSHEFTE FUR CHEMIE
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dc.subject
Bioorthogonal chemistry
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dc.subject
Click chemistry
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dc.subject
Cycloadditions
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dc.subject
Heterocycles
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dc.subject
Kinetics
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dc.subject
Radiochemistry
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dc.title
Post-radiolabeling thioether oxidation to enhance the bioorthogonal reactivity of ¹⁸F-tetrazines
