<div class="csl-bib-body">
<div class="csl-entry">Akhmetshina, A., Bianco, V., Bradić, I., Korbelius, M., Pirchheim, A., Kuentzel, K. B., Eichmann, T. O., Hinteregger, H., Kolb, D., Habisch, H., Liesinger, L., Madl, T., Sattler, W., Radović, B., Sedej, S., Birner-Grünberger, R., Vujić, N., & Kratky, D. (2024). Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice. <i>Molecular Metabolism</i>, <i>79</i>, Article 101869. https://doi.org/10.1016/j.molmet.2023.101869</div>
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dc.identifier.issn
2212-8778
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/192105
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dc.description.abstract
Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the importance of lysosomal hydrolysis in skeletal muscle (SM), research in this area is limited. We hypothesized that LAL may play an important role in SM development, function, and metabolism as a result of lipid and/or carbohydrate metabolism disruptions.
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dc.description.sponsorship
FWF - Österr. Wissenschaftsfonds
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dc.language.iso
en
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dc.publisher
ELSEVIER
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dc.relation.ispartof
Molecular Metabolism
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.subject
Energy metabolism
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dc.subject
LAL
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dc.subject
LAL deficiency
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dc.subject
Lal-deficient mouse
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dc.subject
Muscle proteomics
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dc.title
Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice
