<div class="csl-bib-body">
<div class="csl-entry">Besleaga, M., Ebner, K., Ertl, S., Glieder, A., Spadiut, O., & Kopp, J. (2023, November). <i>Bi-directional promoter systems allow methanol-free production of hard to express unspecific peroxygenases with Komagataella phaffii</i> [Poster Presentation]. PEGS Europe 2023 - Protein & Antibody Engineering Summit, Lisbon, Portugal. http://hdl.handle.net/20.500.12708/192731</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/192731
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dc.description.abstract
Methanol induction systems are conventionally used in Komagataella phaffii to achieve high recombinant protein titers. However, methanol is toxic for the cells and leads to high cell stress which potentially hinders recombinant protein production. To overcome this bottleneck, bi-directional promoter systems can be used to perform co-expression of the target protein and a helper protein (chaperone) in parallel allowing methanol-free recombinant protein production leading to a sustainable processes
en
dc.description.sponsorship
FFG - Österr. Forschungsförderungs- gesellschaft mbH
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dc.language.iso
en
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dc.subject
Methanol
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dc.subject
Komagataella phaffii
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dc.subject
recombinant protein
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dc.subject
bi-directional protomer
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dc.title
Bi-directional promoter systems allow methanol-free production of hard to express unspecific peroxygenases with Komagataella phaffii
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dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
bisy e.U., Austria
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dc.contributor.affiliation
bisy e.U., Austria
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dc.contributor.affiliation
Management Center Innsbruck, Austria
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dc.relation.grantno
880555
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dc.type.category
Poster Presentation
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tuw.project.title
Kaskadenproduktion für bidirektionale Promotorsysteme in P. pastoris
