<div class="csl-bib-body">
<div class="csl-entry">Templ, J., & Schnürch, M. (2023, June 19). <i>Unlocking Monoselective N-Methylation with Quaternary Ammonium Salts</i> [Conference Presentation]. XLVII “A. Corbella” International Summer School on Organic Synthesis 2023, Gargnano, Italy.</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/193047
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dc.description.abstract
We herein report the use of phenyl trimethylammonium iodide (PhMe3NI) as a safe, nontoxic, and easy-to-handle reagent for an absolutely monoselective N-methylation of amides and related compounds as well as for the N-methylation of indoles. In addition, we expanded the method to N-ethylation using PhEt3NI. The ease of operational setup, high yields of ≤99%, high functional group tolerance, and especially the excellent monoselectivity for amides make this method attractive for late-stage methylation of bioactive compounds.
en
dc.description.sponsorship
FWF - Österr. Wissenschaftsfonds
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dc.language.iso
en
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dc.subject
Ammonium salts
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dc.subject
Methylation
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dc.subject
mono-selective
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dc.subject
Amides
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dc.subject
Indoles
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dc.title
Unlocking Monoselective N-Methylation with Quaternary Ammonium Salts
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dc.type
Presentation
en
dc.type
Vortrag
de
dc.relation.grantno
P 33064-N
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dc.type.category
Conference Presentation
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tuw.project.title
Substitution von gasförmigen Reagenzien durch Feststoffe
