<div class="csl-bib-body">
<div class="csl-entry">Ret, D., Gentile Salvatore Alessio, Garcia de Otazo Hernandez, D., Monti, V., Ammaturo, A., Knaus, S., & Untersmayr, E. (2023, September 14). <i>The fate of dietary immuno-modulating glycan along the gastrointestinal tract</i> [Poster Presentation]. ÖGAI Annual Meeting 2023, Linz, Austria. http://hdl.handle.net/20.500.12708/193353</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/193353
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dc.description.abstract
Background: Glycan structures, which are bound to the surface of proteins and lipids, are involved in
numerous physiological and pathological processes including cell-cell interaction, antibody receptor
binding, cellular infection by viruses and many other. Codified in the glycan structure, each nutrient
contains a specifc glycosignature depending on the dietary source. Moreover, dietary glycans might
influence human health due to potential incooperation of foreign glycans in the human glycome.
Thus, we aimed to determine the glycan composition of different food sources and of samples
collected along the gastrointestinal tract for a better understanding of the fate of dietary glycans.
Method: The N-glycome of different food products and oro-gastrointestinal samples was
characterized by MALDI mass spectrometry in positive mode after purification and derivatization
with methylamine. After labelling with DMBA, total and specific sialic acid content was quantified by
HPLC-RP-FL.
Results: We observed substantial variations in N-glycome and monosaccharide composition
depending on the source of the food: vegetable, fungal, meat, milk (human vs animal milk), and
cheese (fermented milk). Starting from the mouth throught the stomach and the intestine, different
degree of gylcan hydrolysis was observed, with mainly the sialic acid residues being cleaved from the
glycan structure.
Conclusion: Our results clearly confirm the species-specific glycan pattern reflected by a distinct N-
glycome and sialic acid amount and composition in different food, but also in gastrointestinal
samples. As the dietary glycan composition influences human health, immuno-nutritional effects
should be taken into consideration.
en
dc.language.iso
en
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dc.subject
immunology glycan inflammation
en
dc.title
The fate of dietary immuno-modulating glycan along the gastrointestinal tract
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
Medical University of Vienna, Austria
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dc.contributor.affiliation
TU Wien
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dc.contributor.affiliation
Medical University of Vienna, Austria
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dc.type.category
Poster Presentation
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tuw.researchTopic.id
M2
-
tuw.researchTopic.id
M6
-
tuw.researchTopic.id
M4
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tuw.researchTopic.name
Materials Characterization
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.name
Non-metallic Materials
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tuw.researchTopic.value
40
-
tuw.researchTopic.value
20
-
tuw.researchTopic.value
40
-
tuw.publication.orgunit
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie
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tuw.author.orcid
0000-0002-7461-0923
-
tuw.author.orcid
0009-0002-3652-6189
-
tuw.author.orcid
0000-0003-0126-3868
-
tuw.author.orcid
0000-0002-1963-499X
-
tuw.event.name
ÖGAI Annual Meeting 2023
en
tuw.event.startdate
14-09-2023
-
tuw.event.enddate
16-09-2023
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Linz
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tuw.event.country
AT
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tuw.event.presenter
Ret, Davide
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wb.sciencebranch
Chemie
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wb.sciencebranch
Klinische Medizin
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wb.sciencebranch
Medizinische Biochemie, Humangenetik
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wb.sciencebranch.oefos
1040
-
wb.sciencebranch.oefos
3020
-
wb.sciencebranch.oefos
3013
-
wb.sciencebranch.value
40
-
wb.sciencebranch.value
20
-
wb.sciencebranch.value
40
-
item.fulltext
no Fulltext
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item.grantfulltext
none
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
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item.languageiso639-1
en
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item.openairetype
conference poster not in proceedings
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item.cerifentitytype
Publications
-
crisitem.author.dept
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie
-
crisitem.author.dept
Medical University of Vienna
-
crisitem.author.dept
E163 - Institut für Angewandte Synthesechemie
-
crisitem.author.dept
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie
-
crisitem.author.dept
TU Wien
-
crisitem.author.dept
E913 - Betriebsrat (DA) für das wissenschaftliche und künstlerische Universitätspersonal
