<div class="csl-bib-body">
<div class="csl-entry">Klement, L., Pfennigbauer, K., Bader, D., Krall, S., Fruhmann, P., & Holzer, B. (2023, May 2). <i>N-Heterocyclic carbene-based self-assembled monolayers as new materials for biosensors</i> [Poster Presentation]. 2nd Conference of Applied Surface Technology (COAST 2023), Wien, Austria. http://hdl.handle.net/20.500.12708/194444</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/194444
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dc.description.abstract
Self-assembled monolayers (SAMs) of organic molecules have been used for a wide range of applications in medicine, surface protection as well as (bio)electronic devices. Extensive efforts have been dedicated to implement biomolecules in gold based diagnostic tools. Using SAMs as an interface between metal surfaces and biological moieties. This modification allows for covalent attachment of receptors to gold, avoiding denaturation usually associated with physical adsorption approaches. In this context, thiol-SAMs containing ethylene glycol (PEG) subunits proved to be effective linkers to prevent nonspecific adsorption at the sensor surface. However, major drawbacks of thiol-SAMs such as limited thermal and long-term stability under ambient conditions as well as their sensitivity to oxidation of the sulfur headgroups hamper their application.
Recently, stable traceless single-source N-heterocyclic carbenes (NHC) have been introduced as anchor groups on gold. Their thermal and chemical stability render these compounds interesting for biosensing applications. In the present work, the synthesis and characterization of water-soluble PEG substituted NHC-SAMs will be presented. These new NHC-SAMs materials will be applied to functionalize flat gold substrates. Furthermore, these functionalized gold substrates will be used to immobilize biological moieties and tested toward their applicability in biosensors.
en
dc.language.iso
en
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dc.subject
Biosensors
en
dc.subject
N-heterocyclische Carbene
de
dc.subject
Surface Plasmon Resonance (SPR)
en
dc.title
N-Heterocyclic carbene-based self-assembled monolayers as new materials for biosensors
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
TU Wien, Austria
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dc.contributor.affiliation
TU Wien, Austria
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dc.type.category
Poster Presentation
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tuw.researchTopic.id
M2
-
tuw.researchTopic.id
M1
-
tuw.researchTopic.id
M6
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tuw.researchTopic.name
Materials Characterization
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tuw.researchTopic.name
Surfaces and Interfaces
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
20
-
tuw.researchTopic.value
60
-
tuw.researchTopic.value
20
-
tuw.publication.orgunit
E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie
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tuw.author.orcid
0009-0008-6803-0472
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tuw.author.orcid
0000-0001-9165-5202
-
tuw.author.orcid
0000-0003-4400-9827
-
tuw.event.name
2nd Conference of Applied Surface Technology (COAST 2023)
en
tuw.event.startdate
02-05-2023
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tuw.event.enddate
03-05-2023
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Wien
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tuw.event.country
AT
-
tuw.event.institution
TU Wien
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tuw.event.presenter
Klement, Lavinia
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wb.sciencebranch
Chemie
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wb.sciencebranch
Chemische Verfahrenstechnik
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wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
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wb.sciencebranch.oefos
1040
-
wb.sciencebranch.oefos
2040
-
wb.sciencebranch.oefos
3012
-
wb.sciencebranch.value
60
-
wb.sciencebranch.value
20
-
wb.sciencebranch.value
20
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item.fulltext
no Fulltext
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
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item.languageiso639-1
en
-
item.cerifentitytype
Publications
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item.openairetype
conference poster not in proceedings
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item.grantfulltext
none
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crisitem.author.dept
E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie
-
crisitem.author.dept
E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie
-
crisitem.author.dept
E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie
-
crisitem.author.dept
TU Wien
-
crisitem.author.dept
TU Wien
-
crisitem.author.dept
E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie
-
crisitem.author.orcid
0009-0008-6803-0472
-
crisitem.author.orcid
0000-0001-9165-5202
-
crisitem.author.orcid
0000-0003-4400-9827
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
-
crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
