<div class="csl-bib-body">
<div class="csl-entry">Bruckner, J. (2024). <i>Development of a LC-MS screening method for plant protection products</i> [Diploma Thesis, Technische Universität Wien]. reposiTUm. https://doi.org/10.34726/hss.2024.107352</div>
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dc.identifier.uri
https://doi.org/10.34726/hss.2024.107352
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/196506
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dc.description
Abweichender Titel nach Übersetzung der Verfasserin/des Verfassers
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dc.description.abstract
Plant protection products (ppps) play an important role in food production. They are highly regulated, requiring authorisation prior to their market introduction. Post-authorisation control and monitoring of ppps on the market are of high importance to ensure their safety and efficacy and hinder the use of illegal (e.g. counterfeit) products. Screening by gas chromatography-mass spectrometry (GC-MS) has been successfully used to determine deviations from the approved formulation or the presence of impurities. The limitation of GC-MS screening is that only volatile compounds can be analysed. Therefore, in the course of this diploma thesis a novel liquid chromatography - high resolution mass spectrometry (LC-hrMS) screening method was developed to overcome this limitation. The screening is based on reversed phase LC separation coupled to a quadrupole time of flight (qTOF) mass spectrometer utilizing an in-house database of ppp constituents.A simple sample preparation includes sonication of a methanolic extract and direct injection after a single dilution step (dilute-and-shoot strategy). The LC method is based on a buffered water/2-propanol gradient to cover a broad range of polarities with a balance between separation power and analysis time. An in-house database containing 54 active substances and 25 co-formulants including sum formulae, retention times and at least one characteristic fragment was established. Validation was performed following the SANTE/11312/2021 guideline and 47 active substances and 12 co-formulants met the defined requirements to be included in the qualitative screening.The developed method will be applied to a broad range of ppp samples and extend the analytical scope of market control in Austria.
en
dc.language
English
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dc.language.iso
en
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dc.rights.uri
http://rightsstatements.org/vocab/InC/1.0/
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dc.subject
Massenspektrometrie
de
dc.subject
Pflanzenschutzmittel
de
dc.subject
Mass Spectrometry
en
dc.subject
Plant protection products
en
dc.title
Development of a LC-MS screening method for plant protection products
en
dc.title.alternative
Entwicklung eines LC-MS-Screeningverfahrens für Pflanzenschutzmittel
de
dc.type
Thesis
en
dc.type
Hochschulschrift
de
dc.rights.license
In Copyright
en
dc.rights.license
Urheberrechtsschutz
de
dc.identifier.doi
10.34726/hss.2024.107352
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dc.contributor.affiliation
TU Wien, Österreich
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dc.rights.holder
Jonathan Bruckner
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dc.publisher.place
Wien
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tuw.version
vor
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tuw.thesisinformation
Technische Universität Wien
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tuw.publication.orgunit
E164 - Institut für Chemische Technologien und Analytik