<div class="csl-bib-body">
<div class="csl-entry">Fuchs, M., Nalbach, M., Rufin, M., Andriotis, O., Battle, L., Docaj, A., Carriero, A., & Thurner, P. (2023). Tensile Testing of Single Collagen Fibrils from Achilles Tendons from an Osteogensis Imperfecta Mouse Model. In <i>ESB 2023 : 28th Congress of the European Society of Biomechanics : Book of Abstracts</i> (pp. 258–258). European Society of Biomechanics.</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/196668
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dc.description.abstract
The homozygous oim mouse model of osteogenesis imperfecta forms homotrimeric collagen type I molecules, which assemble into fragile bone tissue. Counterintuitively, it has been shown that individual collagen fibrils from oim/oim (severe OI type III) tail tendons have higher ultimate stress compared to wild-type (WT) fibrils. However, collagen fibril mechanics are in part steered by the prevalence of enzymatic and non-enzymatic crosslinks between collagen molecules, and elevated non-enzymatic crosslinks have been reported in the bones of the oim mouse, compared to WT.
So far, only fibrils from the positional tail tendons were investigated from oim/oim and littermate WT mice. No data exists on fibrils from energy-storing tendons. To fill this gap, here we report the mechanical properties of oim/oim and WT fibrils obtained from Achilles tendons.
en
dc.language.iso
en
-
dc.subject
collagen fibrils
en
dc.subject
Osteogenesis Imperfecta
en
dc.subject
Achilles Tendon
en
dc.title
Tensile Testing of Single Collagen Fibrils from Achilles Tendons from an Osteogensis Imperfecta Mouse Model
en
dc.type
Inproceedings
en
dc.type
Konferenzbeitrag
de
dc.contributor.affiliation
City College of New York, United States of America (the)
-
dc.contributor.affiliation
City College of New York, United States of America (the)
-
dc.contributor.affiliation
City College of New York, United States of America (the)
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dc.description.startpage
258
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dc.description.endpage
258
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dc.type.category
Abstract Book Contribution
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tuw.booktitle
ESB 2023 : 28th Congress of the European Society of Biomechanics : Book of Abstracts
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tuw.relation.publisher
European Society of Biomechanics
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
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tuw.publication.orgunit
E317-02 - Forschungsbereich Biomechanik
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tuw.publication.orgunit
E056-12 - Fachbereich ENROL DP
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dc.description.numberOfPages
1
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tuw.author.orcid
0000-0002-1768-8118
-
tuw.author.orcid
0000-0003-4107-1510
-
tuw.author.orcid
0000-0001-8103-4795
-
tuw.author.orcid
0000-0001-7588-9041
-
tuw.event.name
28th Congress of the European Society of Biomechanics (ESB2023)
en
tuw.event.startdate
09-07-2023
-
tuw.event.enddate
12-07-2023
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Maastricht
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tuw.event.country
NL
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tuw.event.presenter
Fuchs, Magdalena
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tuw.event.track
Multi Track
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wb.sciencebranch
Maschinenbau
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wb.sciencebranch
Sonstige Technische Wissenschaften
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wb.sciencebranch
Sonstige Humanmedizin, Gesundheitswissenschaften
-
wb.sciencebranch.oefos
2030
-
wb.sciencebranch.oefos
2119
-
wb.sciencebranch.oefos
3059
-
wb.sciencebranch.value
40
-
wb.sciencebranch.value
30
-
wb.sciencebranch.value
30
-
item.cerifentitytype
Publications
-
item.fulltext
no Fulltext
-
item.languageiso639-1
en
-
item.grantfulltext
none
-
item.openairetype
conference paper
-
item.openairecristype
http://purl.org/coar/resource_type/c_5794
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crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
E317-02 - Forschungsbereich Biomechanik
-
crisitem.author.dept
City College of New York, United States of America (the)
-
crisitem.author.dept
City College of New York, United States of America (the)
-
crisitem.author.dept
City College of New York, United States of America (the)
-
crisitem.author.dept
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.orcid
0000-0002-1768-8118
-
crisitem.author.orcid
0000-0003-4107-1510
-
crisitem.author.orcid
0000-0001-8103-4795
-
crisitem.author.orcid
0000-0001-7588-9041
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E317 - Institut für Leichtbau und Struktur-Biomechanik
-
crisitem.author.parentorg
E300 - Fakultät für Maschinenwesen und Betriebswissenschaften