Many thermodynamic mixture and biological multicomponent models can be described by cross-diffusion systems. Although the diffusion matrices are generally neither symmetric and nor positive definite, the systems often possess an entropy (or free energy) structure. We aim to “translate” this entropy structure to finite-volume discretizations. The main difficulty is to adapt the nonlinear chain rule to the discrete level. In this talk, we present two strategies to define a discrete chain rule, assuming either that the total entropy is the sum of individual entropies or that the entropy describes volume-filling models. Both strategies use suitable mean formulas, based on the mean-value theorem and the convexity of the entropy functional. This leads to convergent and structure-preserving numerical schemes. Examples include models for segregating populations and Maxwell-Stefan systems for gas mixtures.