<div class="csl-bib-body">
<div class="csl-entry">Erian, A. M., Gibisch, M., & Pflügl, S. (2018). Engineered E. coli W enables efficient 2,3-butanediol production from glucose and sugar beet molasses using defined minimal medium as economic basis. <i>Microbial Cell Factories</i>, <i>17</i>, 1–17. https://doi.org/10.1186/s12934-018-1038-0</div>
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dc.identifier.issn
1475-2859
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/19883
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dc.description.abstract
Efficient microbial production of chemicals is often hindered by the cytotoxicity of the products or by the pathogenicity of the host strains. Hence 2,3-butanediol, an important drop-in chemical, is an interesting alternative target molecule for microbial synthesis since it is non-cytotoxic. Metabolic engineering of non-pathogenic and industrially relevant microorganisms, such as Escherichia coli, have already yielded in promising 2,3-butanediol titers showing the potential of microbial synthesis of 2,3-butanediol. However, current microbial 2,3-butanediol production processes often rely on yeast extract as expensive additive, rendering these processes infeasible for industrial production.
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dc.language.iso
en
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dc.publisher
BMC
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dc.relation.ispartof
Microbial Cell Factories
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.subject
3-butanediol production
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dc.subject
Acetoin
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dc.subject
Chemically defined medium
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dc.subject
Complex protein hydrolysates
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dc.subject
E. coli W
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dc.subject
High rate and yield 2
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dc.subject
metabolic engineering
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dc.subject
Promoter fine tuning
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dc.subject
Sugar beet molasses
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dc.subject
pykA knock-out
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dc.title
Engineered E. coli W enables efficient 2,3-butanediol production from glucose and sugar beet molasses using defined minimal medium as economic basis