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<div class="csl-entry">Veiter, L., Kager, J., & Herwig, C. (2020). Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control. <i>Microbial Cell Factories</i>, <i>19</i>, 1–14. https://doi.org/10.1186/s12934-020-1288-5</div>
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dc.identifier.issn
1475-2859
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/19885
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dc.description.abstract
Biomass growth of Pencillium chrysogenum is characterised by a distinct pellet morphology consisting of compact hyphal agglomerates. Fungal pellets are advantageous in industrial process control due to rheological advantages but lead to biomass degradation due to diffusional limitations of oxygen and substrate in the pellet's core. Several fermentation parameters are known to affect key pellet characteristics regarding morphology, viability and productivity. Pellet morphology and size are affected by agitation. Biomass viability and productivity are tightly interlinked with substrate uptake and dissolved oxygen concentration.
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dc.language.iso
en
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dc.publisher
BMC
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dc.relation.ispartof
Microbial Cell Factories
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dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
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dc.subject
design of experiment
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dc.subject
filamentous fungi
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dc.subject
flow cytometry
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dc.subject
morphology
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dc.subject
multiple linear regression
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dc.subject
pellets
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dc.subject
Penicillium chrysogenum
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dc.subject
viability
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dc.title
Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control