<div class="csl-bib-body">
<div class="csl-entry">Templ, J., & Schnürch, M. (2024, January 23). <i>Mashing up Tsuji-Trost Allylation - A mechanochemical approach</i> [Conference Presentation]. European Meeting on C-H Activation, Portugal.</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/199765
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dc.description.abstract
We present the first solvent‐free, mechanochemical protocol for a palladium‐catalyzed Tsuji–Trost allylation. This approach features exceptionally low catalyst loadings (0.5 mol %), short reaction times (<90 min), and a simple setup, eliminating the need for air or moisture precautions, making the process highly efficient and environmentally benign. We introduce solid, nontoxic, and easy‐to‐handle allyl trimethylammonium salts as valuable alternative to volatile or hazardous reagents. Our approach enables the allylation of various O‐, N‐, and C‐nucleophiles in yields up to 99 % even for structurally complex bioactive compounds, owing to its mild conditions and exceptional functional group tolerance.
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dc.description.sponsorship
European Commission
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dc.language.iso
en
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dc.subject
Mechanochemistry
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dc.subject
Tsuji-Trost Allylation
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dc.subject
Palladium Catalysis
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dc.subject
Ball Milling
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dc.subject
solvent-free
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dc.title
Mashing up Tsuji-Trost Allylation - A mechanochemical approach
