<div class="csl-bib-body">
<div class="csl-entry">Templ, J., & Schnürch, M. (2024, May 29). <i>Shaken, not stirred ! - ultra-fast solvent-free Wittig reaction</i> [Conference Presentation]. TCH Science Days, Austria.</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/199766
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dc.description.abstract
30 Seconds to success! – The Wittig reaction, a fundamental and extensively utilized reaction in organic chemistry, enables the efficient conversion of carbonyl compounds to olefins using phosphonium salts. Traditionally, meticulous reaction setup, including the pre-formation of a reactive ylide species via deprotonation of a phosphonium salt, is crucial for achieving high-yielding reactions under classical solution-based conditions. In this report, we present an unprecedented protocol for an ultra-fast mechanochemically driven Wittig reaction under solvent-free and ambient conditions, eliminating the need for tedious ylide pre-formation under strict air and moisture exclusion. A range of aldehydes and ketones were reacted with diverse phosphonium salts under high-speed ball milling conditions, giving access to the respective olefins in only 30 seconds.
en
dc.description.sponsorship
FWF - Österr. Wissenschaftsfonds
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dc.language.iso
en
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dc.subject
Mechanochemistry
en
dc.subject
Olefination
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dc.subject
solvent-free
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dc.subject
high-energy ball milling
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dc.subject
oxidation
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dc.title
Shaken, not stirred ! - ultra-fast solvent-free Wittig reaction
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dc.type
Presentation
en
dc.type
Vortrag
de
dc.relation.grantno
P 33064-N
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dc.type.category
Conference Presentation
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tuw.project.title
Substitution von gasförmigen Reagenzien durch Feststoffe
