<div class="csl-bib-body">
<div class="csl-entry">Hondl, N., Holub, E., Lin, K.-L., Diosángeles Soto Véliz, Sahlgren, C., Lendl, B., & Ramer, G. (2024, September 23). <i>Advancements in Infrared Spectroscopy for Cancer Detection</i> [Conference Presentation]. Chemietage 2024, Graz, Austria. http://hdl.handle.net/20.500.12708/206424</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/206424
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dc.description.abstract
Cancer is a global public health challenge and one of the leading causes of death worldwide. Treatment outcomes significantly improve with early detection and intervention, prompting continuous advancements in cancer detection methods. Due to its ability for label free chemical imaging, Mid-IR has been used by multiple groups to identify cancerous tissues and cells [1] and to supplant current chemical staining-based pathology approaches.
Our goal is to use IR to distinguish between healthy, cancerous, and metastasizing cells in tumor-on-a-chip systems. While FTIR imaging has been highly successful with tissue sections [2], applications in large, water-filled channels demands a different approach. We have developed a mid-IR photothermal (MIP) spectroscopy setup specifically tailored for organ-on-a-chip spectroscopy. This instrument allows for sensitive absorption imaging in the presence of several millimeters of water and does not need further adaptation for mid-IR spectroscopy, aside from requiring an IR-transparent sample carrier.
Here, we present our findings on utilizing clustering algorithms and infrared spectroscopy to differentiate between cancerous and healthy cells. Additionally, we compare spectra obtained through conventional FTIR microscopy with those acquired using our MIP setup. As a final step, we are able to analyze the chemical composition of the individual cells through imaging.
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[1] Liu Dong et al., ‘Evaluation of Fourier Transform Infrared (FTIR) Spectroscopy with Multivariate Analysis as a Novel Diagnostic Tool for Lymph Node Metastasis in Gastric Cancer’, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 289 (2023) 122209.
[2] Hersh K. Bhargava et al., ‘Computationally Derived Image Signature of Stromal Morphology Is Prognostic of Prostate Cancer Recurrence Following Prostatectomy in African American Patients’, Clinical Cancer Research 26, no. 8 (2020): 1915–23
en
dc.description.sponsorship
European Commission
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dc.language.iso
en
-
dc.subject
OPTIR
en
dc.subject
Infrared-Spectroscopy
en
dc.title
Advancements in Infrared Spectroscopy for Cancer Detection
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
Åbo Akademi University, Finland
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dc.contributor.affiliation
Åbo Akademi University, Finland
-
dc.contributor.affiliation
Åbo Akademi University, Finland
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dc.relation.grantno
953234
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dc.type.category
Conference Presentation
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tuw.project.title
Tumor und Lymphknoten auf einer Chip Plattform für Krebsstudien
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
-
tuw.publication.orgunit
E164-02-1 - Forschungsgruppe Prozessanalytik
-
tuw.author.orcid
0009-0001-9282-4474
-
tuw.author.orcid
0009-0006-0703-9524
-
tuw.author.orcid
0000-0002-1882-6527
-
tuw.author.orcid
0000-0003-3350-4937
-
tuw.author.orcid
0000-0003-3838-5842
-
tuw.author.orcid
0000-0001-8307-5435
-
tuw.event.name
Chemietage 2024
de
tuw.event.startdate
23-09-2024
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tuw.event.enddate
25-09-2024
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Graz
-
tuw.event.country
AT
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tuw.event.presenter
Hondl, Nikolaus
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tuw.event.track
Multi Track
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wb.sciencebranch
Chemie
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wb.sciencebranch.oefos
1040
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wb.sciencebranch.value
100
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item.languageiso639-1
en
-
item.openairetype
conference paper not in proceedings
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item.grantfulltext
none
-
item.fulltext
no Fulltext
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item.cerifentitytype
Publications
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item.openairecristype
http://purl.org/coar/resource_type/c_18cp
-
crisitem.author.dept
E164-02-1 - Forschungsgruppe Prozessanalytik
-
crisitem.author.dept
E164-02-1 - Forschungsgruppe Prozessanalytik
-
crisitem.author.dept
Åbo Akademi University
-
crisitem.author.dept
Åbo Akademi University
-
crisitem.author.dept
Eindhoven University of Technology
-
crisitem.author.dept
E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
-
crisitem.author.dept
E164-02-1 - Forschungsgruppe Prozessanalytik
-
crisitem.author.orcid
0009-0001-9282-4474
-
crisitem.author.orcid
0009-0006-0703-9524
-
crisitem.author.orcid
0000-0002-1882-6527
-
crisitem.author.orcid
0000-0003-3350-4937
-
crisitem.author.orcid
0000-0003-3838-5842
-
crisitem.author.orcid
0000-0001-8307-5435
-
crisitem.author.parentorg
E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
-
crisitem.author.parentorg
E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
-
crisitem.author.parentorg
E164 - Institut für Chemische Technologien und Analytik
-
crisitem.author.parentorg
E164-02 - Forschungsbereich Umwelt-, Prozessanalytik und Sensoren
