<div class="csl-bib-body">
<div class="csl-entry">Zahoranova, A., Vojtova, L., Dusicka, E., Michlovska, L., Krivankova, N., & Baudis, S. (2020). Hybrid Hydrogel Networks by Photocrosslinking of Thermoresponsive α,ω‐Itaconyl‐PLGA‐PEG‐PLGA Micelles in Water: Influence of the Lithium Phenyl‐2,4,6‐Trimethylbenzoylphosphinate Photoinitinator. <i>Macromolecular Chemistry and Physics</i>, <i>221</i>(17), Article 2000165. https://doi.org/10.1002/macp.202000165</div>
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dc.identifier.issn
1022-1352
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/20690
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dc.description.abstract
Modification of thermogelling biodegradable copolymers with functional groups enables further covalent crosslinking of physical micelle-based hydrogels formed at specific temperature in water. The resulting hybrid hydrogel network exhibits an increase in stiffness and degradation stability. In this work, synthesized well-defined thermoresponsive α,ω-itaconyl-poly(d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (α,ω-itaconyl-PLGA-PEG-PLGA) macromonomers with a high degree of itaconyl-substitution providing free double bonds are photocrosslinked in water at both 25 and 37 °C using lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LiTPO) acting as water-soluble non-toxic photoinitiator. The effect of LiTPO on the thixotropic behavior of macromonomer in water at 25 °C without irradiation is evaluated. With the addition of a low amount of the photoinitiator (0.1 wt%), the degree of copolymer thixotropy increases. However, further increase in the photoinitiator concentration (0.5–3 wt%) leads to a lower degree of thixotropy. The photoinitiator is presumably interfering with the micellar self-assembly of the copolymer. This trend is also reflected in photocrosslinking efficiency, where the hybrid hydrogel networks with the highest storage moduli are achieved with very low concentrations of the photoinitiator (0.1 wt%) at 25 °C, while this trend is reversed at 37 °C. The hydrolytic stability of hydrogels prepared at 37 °C from 17 wt% macromonomer solution with 1% LiTPO exceeds 22 days.
en
dc.language.iso
en
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dc.publisher
Wiley
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dc.relation.ispartof
Macromolecular Chemistry and Physics
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dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
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dc.subject
injectable hydrogels
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dc.subject
photocrosslinking
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dc.subject
photoinitiators
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dc.subject
thermogellation
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dc.subject
thixotropy
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dc.subject
Organic Chemistry
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dc.subject
Polymers and Plastics
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dc.subject
Materials Chemistry
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dc.subject
Physical and Theoretical Chemistry
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dc.subject
Condensed Matter Physics
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dc.title
Hybrid Hydrogel Networks by Photocrosslinking of Thermoresponsive α,ω‐Itaconyl‐PLGA‐PEG‐PLGA Micelles in Water: Influence of the Lithium Phenyl‐2,4,6‐Trimethylbenzoylphosphinate Photoinitinator
en
dc.type
Article
en
dc.type
Artikel
de
dc.rights.license
Creative Commons Namensnennung - Nicht kommerziell 4.0 International
de
dc.rights.license
Creative Commons Attribution - NonCommercial 4.0 International