<div class="csl-bib-body">
<div class="csl-entry">Seidler, K., Ehrmann, K., Steinbauer, P., Rohatschek, A., Andriotis, O., Dworak, C., Koch, T., Bergmeister, H., Grasl, C., Schima, H., Thurner, P., Liska, R., & Baudis, S. (2018). A structural reconsideration: Linear aliphatic or alicyclic hard segments for biodegradable thermoplastic polyurethanes? <i>Journal of Polymer Science</i>, <i>56</i>(19), 2214–2224. https://doi.org/10.1002/pola.29190</div>
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dc.identifier.issn
2642-4150
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/20693
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dc.description.abstract
Thermoplastic polyurethane elastomers (TPUs) with a biodegradable chain extender and different nonaromatic diisocyanate hard segments were synthesized and tested concerning their thermal, mechanical, and degradation properties and for their processability regarding electrospinning. The design of the TPUs was based on the structural modification of the hard segment using linear aliphatic hexamethylene diisocyanate (HMDI), more rigid alicyclic 4,4′-methylene bis(cyclohexylisocyanate) (H12MDI), 1,3-bis(isocyanatomethyl)cyclohexane (BIMC), or isophorone diisocyanate (IPDI). The soft segment consisted of poly(tetrahydrofuran). Bis(2-hydroxyethyl) terephthalate (BET) was used as chain extender with cleavable ester bonds. Some of the polyurethanes based on alicyclic diisocyanate showed better mechanical performance than the less rigid HMDI-based TPU. The TPU in vitro degradability was tested for 25 days at elevated temperatures in PBS buffer and indicated a bulk erosion process. Electrospinning experiments were conducted and promising results with respect to further applicability of these materials in vascular tissue engineering were obtained.
en
dc.language.iso
en
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dc.publisher
Wiley
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dc.relation.ispartof
Journal of Polymer Science
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dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
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dc.subject
biodegradable
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dc.subject
electrospinning
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dc.subject
nontoxic
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dc.subject
thermoplastic polyurethane
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dc.subject
vascular grafts
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dc.title
A structural reconsideration: Linear aliphatic or alicyclic hard segments for biodegradable thermoplastic polyurethanes?
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dc.type
Article
en
dc.type
Artikel
de
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
en
dc.rights.license
Creative Commons Namensnennung - Nicht kommerziell 4.0 International