<div class="csl-bib-body">
<div class="csl-entry">Conibear, A. C. (2024, May 31). <i>Chemical biology tools to understand protein posttranslational modifications in disordered proteins</i> [Presentation]. Departmental Seminar - University of Kyoto, Kyoto, Japan.</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/207447
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dc.description.abstract
Posttranslational modifications regulate the location, interactions, and destruction of a protein, controlling fundamental cellular processes. However, unravelling precise effects of these modifications on proteins is challenging because of difficulties obtaining proteins bearing site-specific modifications for structural and functional studies. Furthermore, effects of posttranslational modifications on protein structure are seldom investigated, leaving a gap in our knowledge of how posttranslational modifications modulate protein function. In this presentation, I will discuss our work towards an understanding of the structural effects of posttranslational modifications in intrinsically disordered proteins and protein regions. I will demonstrate how solid phase peptide synthesis provides access to modified peptides for structural studies and how protein semi-synthesis tools can be used to generate site-specifically modified and segmentally isotope labelled proteins for NMR spectroscopy. I aim to show how integrating chemical protein synthesis with structural biology allows us to gain new insights into the effects of protein posttranslational modifications on protein structure, dynamics and regulation.
en
dc.description.sponsorship
FWF - Österr. Wissenschaftsfonds
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dc.language.iso
en
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dc.subject
Disordered proteins
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dc.subject
Posttranslational Modifications
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dc.subject
Protein synthesis
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dc.title
Chemical biology tools to understand protein posttranslational modifications in disordered proteins
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.relation.grantno
P 36101-B
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dc.type.category
Presentation
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tuw.project.title
Posttranslationale Modifikation von HMGN1 in DNA-Verpackung
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tuw.researchTopic.id
M6
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tuw.researchTopic.id
M8
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.name
Structure-Property Relationsship
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tuw.researchTopic.value
70
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tuw.researchTopic.value
30
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tuw.publication.orgunit
E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie
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tuw.author.orcid
0000-0002-5482-6225
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tuw.event.name
Departmental Seminar - University of Kyoto
en
tuw.event.startdate
31-05-2024
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tuw.event.enddate
31-05-2024
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Kyoto
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tuw.event.country
JP
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tuw.event.institution
Faculty of Chemistry, University of Kyoto
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tuw.event.presenter
Conibear, Anne Claire
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wb.sciencebranch
Chemie
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wb.sciencebranch
Chemische Verfahrenstechnik
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wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
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wb.sciencebranch.oefos
1040
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wb.sciencebranch.oefos
2040
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wb.sciencebranch.oefos
3012
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wb.sciencebranch.value
60
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wb.sciencebranch.value
20
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wb.sciencebranch.value
20
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item.languageiso639-1
en
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item.openairetype
conference presentation
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item.grantfulltext
none
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item.fulltext
no Fulltext
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item.cerifentitytype
Publications
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item.openairecristype
http://purl.org/coar/resource_type/R60J-J5BD
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crisitem.author.dept
E163-03-2 - Forschungsgruppe Molekulare Chemie und Chemische Biologie
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crisitem.author.orcid
0000-0002-5482-6225
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crisitem.author.parentorg
E163-03 - Forschungsbereich Organische und Biologische Chemie
