<div class="csl-bib-body">
<div class="csl-entry">Höhlschen, J. M., Gosset, E., Tomin, T., & Birner-Grünberger, R. (2024, October 20). <i>Investigating the cardioprotective effects of SGLT-2 inhibitors</i> [Poster Presentation]. HUPO 2024, Dresden, Germany. http://hdl.handle.net/20.500.12708/207584</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/207584
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dc.description.abstract
Beyond their initial approvement for treating diabetic conditions, Sodium-Glucose co-transporter 2 (SGLT-2) inhibitors have recently been found to also offer cardioprotective properties. Since cardiovascular problems are one of the major complications that diabetic patients face, this finding was groundbreaking. Meanwhile it was shown that the cardioprotective effects are not limited to diabetic patients and the inhibitors’ approvements have been expanded respectively. Observations from clinical studies hint in the direction that those effects exceed the glucose lowering effect without offering an explanation for the underlying mechanisms.
Since the drug’s target protein SGLT-2 is exclusively expressed in the early proximal tubule where it is responsible for the reabsorption of glucose it remains inconclusive why the positive effects are observed in the heart. To identify off-targets of the drug, thermal proteome profiling is applied. In this method the basic principle is that the thermal stability of proteins is increased when binding to the drug, reflected by an increased stability of the respective protein when applying a temperature gradient. In order to target the off targets in the cardiac environment those experiments are carried out in the human cardiac cell line AC16 (cardiomyocytes derived from left ventricular heart tissue).
en
dc.description.sponsorship
European Commission
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dc.language.iso
en
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dc.subject
gliflozin
en
dc.subject
cardiomyocytes
en
dc.subject
redox proteomics
en
dc.title
Investigating the cardioprotective effects of SGLT-2 inhibitors
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.contributor.affiliation
TU Wien, Austria
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dc.relation.grantno
101034277
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dc.type.category
Poster Presentation
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tuw.project.title
Technik für Biowissenschaften Doktoratsstudium
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tuw.researchinfrastructure
Cell Culture Core Facility (CCCF)
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
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tuw.publication.orgunit
E164-01-3 - Forschungsgruppe Bioanalytik
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tuw.author.orcid
0000-0002-7071-2316
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tuw.author.orcid
0000-0003-3950-0312
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tuw.event.name
HUPO 2024
en
tuw.event.startdate
20-10-2024
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tuw.event.enddate
24-10-2024
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Dresden
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tuw.event.country
DE
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tuw.event.institution
Human Proteome Organisation
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tuw.event.presenter
Höhlschen, Julia Martina
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wb.sciencebranch
Chemie
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wb.sciencebranch
Biologie
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wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
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wb.sciencebranch.oefos
1040
-
wb.sciencebranch.oefos
1060
-
wb.sciencebranch.oefos
3012
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wb.sciencebranch.value
50
-
wb.sciencebranch.value
20
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wb.sciencebranch.value
30
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item.languageiso639-1
en
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item.openairetype
conference poster not in proceedings
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item.grantfulltext
none
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item.fulltext
no Fulltext
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item.cerifentitytype
Publications
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
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crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
TU Wien
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crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
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crisitem.author.orcid
0000-0002-7071-2316
-
crisitem.author.orcid
0000-0003-3950-0312
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
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crisitem.author.parentorg
E164 - Institut für Chemische Technologien und Analytik
