<div class="csl-bib-body">
<div class="csl-entry">Höhlschen, J. M., Tomin, T., & Birner-Grünberger, R. (2024, February 21). <i>SGLT-2 inhibitors and their effect on the proteome of cardiomyocytes</i> [Poster Presentation]. 34th Mass Spectrometry Forum 2024, Wien, Austria.</div>
</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/207684
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dc.description.abstract
A new drug class that offers cardioprotective properties are sodium-glucose co-transporter-2 (SGLT-2) inhibitors, initially used for the treatment of type 2 diabetes. Shortly after their introduction into the market they have been shown to have cardioprotective properties that are beyond the effect of lowering the glucose concentration in the blood. After further investigations, their application in non-diabetic patients suffering from heart diseases has been approved. The underlying mechanisms of the observed effects, however, have not yet been identified.
The aim of the project is to identify the off-targets of SGLT-2 inhibitors by means of thermal profiling. To get a general impression of the influence of Cana-, Dapa- and Empagliflozin on cardiomyocytes, a differentiated human cardiomyocyte cell line (AC16) has been treated with the three Gliflozins in two different concentrations, being the physiological ones and 100 times higher one.
en
dc.description.sponsorship
European Commission
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dc.language.iso
en
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dc.subject
gliflozin
en
dc.subject
cardiomyocytes
en
dc.subject
proteomics
en
dc.title
SGLT-2 inhibitors and their effect on the proteome of cardiomyocytes
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.relation.grantno
101034277
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dc.type.category
Poster Presentation
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tuw.project.title
Technik für Biowissenschaften Doktoratsstudium
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tuw.researchinfrastructure
Cell Culture Core Facility (CCCF)
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tuw.researchTopic.id
M6
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tuw.researchTopic.name
Biological and Bioactive Materials
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tuw.researchTopic.value
100
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tuw.publication.orgunit
E164-01-3 - Forschungsgruppe Bioanalytik
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tuw.author.orcid
0000-0002-7071-2316
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tuw.author.orcid
0000-0003-3950-0312
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tuw.event.name
34th Mass Spectrometry Forum 2024
en
tuw.event.startdate
21-02-2024
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tuw.event.enddate
23-02-2024
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tuw.event.online
On Site
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tuw.event.type
Event for scientific audience
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tuw.event.place
Wien
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tuw.event.country
AT
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tuw.event.institution
Universität Wien
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tuw.event.presenter
Höhlschen, Julia Martina
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tuw.event.track
Single Track
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wb.sciencebranch
Chemie
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wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
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wb.sciencebranch
Anatomie, Pathologie, Physiologie
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wb.sciencebranch.oefos
1040
-
wb.sciencebranch.oefos
3012
-
wb.sciencebranch.oefos
3011
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wb.sciencebranch.value
50
-
wb.sciencebranch.value
30
-
wb.sciencebranch.value
20
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item.languageiso639-1
en
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item.openairetype
conference poster not in proceedings
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item.grantfulltext
none
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item.fulltext
no Fulltext
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item.cerifentitytype
Publications
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item.openairecristype
http://purl.org/coar/resource_type/c_18co
-
crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.orcid
0000-0002-7071-2316
-
crisitem.author.orcid
0000-0003-3950-0312
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
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crisitem.author.parentorg
E164 - Institut für Chemische Technologien und Analytik
