<div class="csl-bib-body">
<div class="csl-entry">Breinsperger, J., Kaiser, M., & Gärtner, P. (2024, July 3). <i>Asymmetric Claisen-Cope rearrangements</i> [Poster Presentation]. 18th Belgian Organic Synthesis Symposium, Liege, Belgium. https://doi.org/10.34726/8481</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/210344
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dc.identifier.uri
https://doi.org/10.34726/8481
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dc.description.abstract
The Claisen rearrangement of allylic aryl ethers typically results in the formation of ortho-allylated phenols. However, if the ortho positions are substituted, a Cope-rearrangement occurs to the para position, concluding the Claisen-Cope reaction. These [3,3]-sigmatropic rearrangements feature a transition state comprising a cyclic array of continuously bonded atoms, which enables high predictability in terms of connectivity and configuration. The aforementioned ability for stereocontrol has led to the development of a limited number of methods for the ortho Claisen rearrangement in recent years. In contrast, the asymmetric para Claisen-Cope rearrangement has been largely overlooked until now.
