DC Field
Value
Language
dc.contributor.author
Höhlschen, Julia Martina
-
dc.contributor.author
Tomin, Tamara
-
dc.contributor.author
Birner-Grünberger, Ruth
-
dc.date.accessioned
2025-01-31T09:36:19Z
-
dc.date.available
2025-01-31T09:36:19Z
-
dc.date.issued
2024-01-15
-
dc.identifier.citation
<div class="csl-bib-body"> <div class="csl-entry">Höhlschen, J. M., Tomin, T., &#38; Birner-Grünberger, R. (2024, January 15). <i>SGLT-2 inhibitors and their effect on the proteome of cardiomyocytes</i> [Presentation]. EuBIC-MS Winter School 2024, Winterberg, Germany. http://hdl.handle.net/20.500.12708/210360</div> </div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/210360
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dc.description.abstract
A new drug class that offers cardioprotective properties are sodium-glucose co-transporter-2 (SGLT-2) inhibitors, initially used for the treatment of type 2 diabetes. Shortly after their introduction into the market they have been shown to have cardioprotective properties that are beyond the effect of lowering the glucose concentration in the blood. After further investigations their application in non-diabetic patients suffering from heart diseases has been approved. The underlying mechanisms of the observed effects, however, have not yet been identified. To get an impression of the influence of Cana-, Dapa- and Empagliflozin on cardiomyocytes, differentiated a human cardiomyocyte cell line (AC16) has been treated with the three Gliflozins in two different concentrations. Moreover, thermal profiling assays (TPP) and the use of activity-based probes (ABP) to identify interaction partners of the drugs are planned to be used in the project.
en
dc.description.sponsorship
European Commission
-
dc.language.iso
en
-
dc.subject
gliflozin
en
dc.subject
proteomics
en
dc.subject
cardiomyocytes
en
dc.title
SGLT-2 inhibitors and their effect on the proteome of cardiomyocytes
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.relation.grantno
101034277
-
dc.type.category
Presentation
-
tuw.project.title
Technik für Biowissenschaften Doktoratsstudium
-
tuw.researchinfrastructure
Cell Culture Core Facility (CCCF)
-
tuw.researchTopic.id
M6
-
tuw.researchTopic.name
Biological and Bioactive Materials
-
tuw.researchTopic.value
100
-
tuw.publication.orgunit
E164-01-3 - Forschungsgruppe Bioanalytik
-
tuw.author.orcid
0000-0002-7071-2316
-
tuw.author.orcid
0000-0003-3950-0312
-
tuw.event.name
EuBIC-MS Winter School 2024
en
tuw.event.startdate
15-01-2024
-
tuw.event.enddate
19-01-2024
-
tuw.event.online
On Site
-
tuw.event.type
Event for scientific audience
-
tuw.event.place
Winterberg
-
tuw.event.country
DE
-
tuw.event.institution
European Proteomics Association
-
tuw.event.presenter
Höhlschen, Julia Martina
-
wb.sciencebranch
Chemie
-
wb.sciencebranch
Biologie
-
wb.sciencebranch
Pharmazie, Pharmakologie, Toxikologie
-
wb.sciencebranch.oefos
1040
-
wb.sciencebranch.oefos
1060
-
wb.sciencebranch.oefos
3012
-
wb.sciencebranch.value
50
-
wb.sciencebranch.value
30
-
wb.sciencebranch.value
20
-
item.languageiso639-1
en
-
item.openairetype
conference presentation
-
item.grantfulltext
none
-
item.fulltext
no Fulltext
-
item.cerifentitytype
Publications
-
item.openairecristype
http://purl.org/coar/resource_type/R60J-J5BD
-
crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01-3 - Forschungsgruppe Bioanalytik
-
crisitem.author.dept
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.orcid
0000-0002-7071-2316
-
crisitem.author.orcid
0000-0003-3950-0312
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E164-01 - Forschungsbereich Imaging und Instrumentelle Analytische Chemie
-
crisitem.author.parentorg
E164 - Institut für Chemische Technologien und Analytik
-
crisitem.project.funder
European Commission
-
crisitem.project.grantno
101034277
-
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